Utility-Of-Cyanoacetic-Acid-Hydrazide-In-Heterocyclic-Synthesis.pdf
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Utility-Of-Cyanoacetic-Acid-Hydrazide-In-Heterocyclic-Synthesis.pdf
General PapersARK1VOC 2006 (ix) 113 156Utility of cvanoacetic acid hydrazide in heterocyclic synthesisSamir Bondock.*Abd El-Gaber Tarhoni, and Ahmed A Utility-Of-Cyanoacetic-Acid-Hydrazide-In-Heterocyclic-Synthesis.pdfA. FaddaDepartment of Chemistry, Faculty of Science, Mansoura University. ET-355Ỉ6 Mansoura, Egypt E-mail: Bondock'a mans.edu. egAbstractTins review describes the synthesis and reactions of cyanoacetic acid hydrazide as building block for the synthesis of polyfunctionalized heterocyclic compounds wi Utility-Of-Cyanoacetic-Acid-Hydrazide-In-Heterocyclic-Synthesis.pdfth pharmacological interestKeywords: Cyanoacetic acid hydrazide, pyrazoles. tlnadiazoles. pyridines, pyrans. pyridazmes. pyrimidines, aiuielated heterUtility-Of-Cyanoacetic-Acid-Hydrazide-In-Heterocyclic-Synthesis.pdf
ocyclesContents1. Introduction2 Synthesis of Cyanoacetic Acid Hydrazide3. Chemical Reactivity4 Reactions of Cyanoacetic Acid Hydrazide4 1 Synthesis ofGeneral PapersARK1VOC 2006 (ix) 113 156Utility of cvanoacetic acid hydrazide in heterocyclic synthesisSamir Bondock.*Abd El-Gaber Tarhoni, and Ahmed A Utility-Of-Cyanoacetic-Acid-Hydrazide-In-Heterocyclic-Synthesis.pdfrazoles and theii fused derivatives4 2 2 Thiazoles and theii fused derivatives4.3.Synthesis of five-membered rings with three heteroatoms4.3.1Triazoles and then fused derivatives4.3.2.Thiadiazoles4.4.Synthesis of six-membered rings with one heteroatom4 4 1 Pyridines and their fused derivatives4 4 2 Utility-Of-Cyanoacetic-Acid-Hydrazide-In-Heterocyclic-Synthesis.pdfPyrans and then fused derivatives4.4.3.Thiopyrans4.5.Synthesis of six-membered rings with two heteroatoms4 5 1 Pyridazines and theii fused derivativesUtility-Of-Cyanoacetic-Acid-Hydrazide-In-Heterocyclic-Synthesis.pdf
4.5.2Pyrimidines and their fused derivatives4.6.Synthesis of six-membered rings with tlu ee heteroatoinsISSN 1424 6376Page 113*ARKATGeneral PapersARK1General PapersARK1VOC 2006 (ix) 113 156Utility of cvanoacetic acid hydrazide in heterocyclic synthesisSamir Bondock.*Abd El-Gaber Tarhoni, and Ahmed A Utility-Of-Cyanoacetic-Acid-Hydrazide-In-Heterocyclic-Synthesis.pdfOn treatment of cyanoacetic acid hydrazide With various reagents, the attack can take place at five possible sites: the nucleophile is able to attack the carbon of the carbonyl function (position 3) and the carbon atom of the nittile function (position 5). While the active methylene group (position Utility-Of-Cyanoacetic-Acid-Hydrazide-In-Heterocyclic-Synthesis.pdf4) and amino groups (positions 1 and 2) ate able to attack electrophiles.NGeneral PapersARK1VOC 2006 (ix) 113 156Utility of cvanoacetic acid hydrazide in heterocyclic synthesisSamir Bondock.*Abd El-Gaber Tarhoni, and Ahmed AGeneral PapersARK1VOC 2006 (ix) 113 156Utility of cvanoacetic acid hydrazide in heterocyclic synthesisSamir Bondock.*Abd El-Gaber Tarhoni, and Ahmed AGọi ngay
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