Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2
Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2
SECTIONCosmetic ProceduresCHAPTER 22Botulinum ToxinLeslie Baumann. MD Mohamed L Elsaie. MD I ÍS3 Grunebaum, MORotulinum toxin (RTX), an exotoxm produc Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2ced by rhe. bacteria C.lữịưưhiiiH Ịrơt/I linum, occurs naturally in nature. 15 J X induces a bilaterally symmetric descending neuroparalytic condition called botulism. The Word “botulinum’ is derived from the Ijitin word for sausage, “botu-lus.' Botulism was so named during the Napoleonic Empire in Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2the early 1300s when it was noted to be triggered by the ingestion ut spoiled sausages. Later, German physician Justmus Kerner described food-bome botEbook Cosmetic dermatology - Principles and practice (2nd edition): Part 2
ulism and Its clinical symptoms during the period between 1317 and 1822. In 1946. Schantz reported isolating BTX type A in its crystalline form, and nSECTIONCosmetic ProceduresCHAPTER 22Botulinum ToxinLeslie Baumann. MD Mohamed L Elsaie. MD I ÍS3 Grunebaum, MORotulinum toxin (RTX), an exotoxm produc Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2ữìulinum A exotoxin, commonly known as botulinum toxin type A (BTX-A), has emerged over the last decade as one of the most popular methods of combating cutaneous signs of aging, particularly the dynamic wrinkles of the face. The therapeutic application of this potent neurotoxin has carved a comforta Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2ble niche in the cosmetic realm of dermatology practice for practical reasons: Results appear within several days of administration, the procedure ItsEbook Cosmetic dermatology - Principles and practice (2nd edition): Part 2
elf is short in duration and relatively uncomplicated. and side effects arc minimal.Although medicinal use of BTX by physicians is widespread, professSECTIONCosmetic ProceduresCHAPTER 22Botulinum ToxinLeslie Baumann. MD Mohamed L Elsaie. MD I ÍS3 Grunebaum, MORotulinum toxin (RTX), an exotoxm produc Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2nd die longevity of prepared and refrigerated BTX remain debated issues (Box 22-1). The methods described in this chapter are those used most frequently by the primary author. 1 he novice injector should cry the various methods espoused by experienced specialists to determine which yields the best r Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2esults in his/her own practice.■ MECHANISMS OF ACTIONAcetylcholine (ACh) is the neurotransmitter associated with induction of mus-BOX 22-1 Units of BoEbook Cosmetic dermatology - Principles and practice (2nd edition): Part 2
tulinum ToxinOne unit ftjj of ŨTX IS the dose that well'd t» letnai to 5ƠN> HUj-j of the Sf»:ii»e inousú spoúvs tested. Fur a 70-kg per sari, tlxs IofSECTIONCosmetic ProceduresCHAPTER 22Botulinum ToxinLeslie Baumann. MD Mohamed L Elsaie. MD I ÍS3 Grunebaum, MORotulinum toxin (RTX), an exotoxm produc Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2use of lhese vaiiations. i: is important lo know wiliuh ty:;e ui BTX was Liial VY|«I araltal-ing rinsing infarmatkin in the literature. For cosmetic irriioahcns, injection of arorcm mate?/ 2U to /5 u doses of Botox IS Mil cal. Practitioners ha-ic used dcscs as Fieri as 10t>0 BuIl-x unite to (real cu Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2ninal isi’sy and other fiHirdcgc (Xinditkins.cle movement. BTX achieves chemical denervation of striated muscles by cleaving one or more of the proteiEbook Cosmetic dermatology - Principles and practice (2nd edition): Part 2
ns required for rhe release of ACh (lig. 22-1. The target protein depends on the serotype of toxin used (Table 22-1). The result is temporary flaccid SECTIONCosmetic ProceduresCHAPTER 22Botulinum ToxinLeslie Baumann. MD Mohamed L Elsaie. MD I ÍS3 Grunebaum, MORotulinum toxin (RTX), an exotoxm produc Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2 seven BTX serotypes (A-G). Serotype A is the most potent and vzas the first to be made▲ FIGURE 22-1 Botulinum toxins inhibit the rơease ot aoetylctoine into tlic reuromuscukii junction.169TABLE 22-1Binding Sites of Various Toxin SerotypesTomi SerotypeBĨXABIX-BBĨX-C1BTX-Ỉ)8TX-EBĨX rBIX G&N3N3 SiteSN Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2AP 25SynaptebicwnSNAP-25 and syntaxinSynapfcfireviriSNAP-25SvnaptcbfwnSynaptcbfcvinavailable in the United States for medical use. Botox Cosmetic’*1 (Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2
Allergan Inc., Irvine, CA) and Dysport™ (Ipsen Products, Maidenhead, Berkshire, UK) arc both formed from serotype A. which functions by cleaving the SSECTIONCosmetic ProceduresCHAPTER 22Botulinum ToxinLeslie Baumann. MD Mohamed L Elsaie. MD I ÍS3 Grunebaum, MORotulinum toxin (RTX), an exotoxm produc Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2 an intact SNARE complex, composed of synaptobrevin. SNAP-25, and syntaxin, is necessary for Vesicles containing ACh to fuse with the cell membrane and to release ACh into the neuromuscular junction rig 22-J). BTX-B, now available in the United States as Myobloc1** (known as Neurobloc in Europe), cl Ebook Cosmetic dermatology - Principles and practice (2nd edition): Part 2eaves synaptobrevin, thus preventing the release of ACh.HAPTER 22 BOTULINUM TOXINCOSMETIC DERMATOLOGY: PRINCIPLES AND PRACTICESECTIONCosmetic ProceduresCHAPTER 22Botulinum ToxinLeslie Baumann. MD Mohamed L Elsaie. MD I ÍS3 Grunebaum, MORotulinum toxin (RTX), an exotoxm producSECTIONCosmetic ProceduresCHAPTER 22Botulinum ToxinLeslie Baumann. MD Mohamed L Elsaie. MD I ÍS3 Grunebaum, MORotulinum toxin (RTX), an exotoxm producGọi ngay
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