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Ebook Metabolism at a slance (4/E): Part 2

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Nội dung chi tiết: Ebook Metabolism at a slance (4/E): Part 2

Ebook Metabolism at a slance (4/E): Part 2

Metabolism of glucose to fatty acids and triacylglycerol27A hrlcfd.-scr1ptl

Ebook Metabolism at a slance (4/E): Part 2time tv luuk al IrtSK yWycrnd Ixwynlhwatill mure detailThe liver, adipose t-ssucand lactating HMIIK.7 Blind arc the principal imntwkt ill lipnp«w

riKyl£lycwnl lynrtwsisy liwr .lid >i". ;XW tlsax nuke Irtacyljtlfwral ứvm ghicose under condition* Ebook Metabolism at a slance (4/E): Part 2

when rhe baity rat more than enough food w ralúíy i.1 irnnittJlate Itvetl» far vnti-aChart 27.1: synthesis of triacylglycerols from glucose Importance

Ebook Metabolism at a slance (4/E): Part 2

of citrate bl activating fatty acid synthesisItie -Ciitnchcnrirtcri In thí high energy state his Increased amounts nt ATI' and NADU Tlsrse riwlabulii

Metabolism of glucose to fatty acids and triacylglycerol27A hrlcfd.-scr1ptl

Ebook Metabolism at a slance (4/E): Part 2nlly. the nwisMius iuuilriCr and citrate <1.11-enubte. and their conevurjllcn wuliln the tsRoehmidrlun minuses. Al toe coiwcnrrotlon nt Citi lie rises

, Itdlttuscsvla the tricar boxylaxc carrier trau ihemibxlKimlriun into llteiykwl. whtrvalrate«r-«s IhrivftunlxTO-1Citrate and ATP are allosterl: regul Ebook Metabolism at a slance (4/E): Part 2

ators that reduce the metabolic fluxI hnxtgh glyirdisis I»ill I .liíliại pbrriphrifruCtoAinisu-1. ttwtety -nt luting enebixillw title the pcaftoue pli

Ebook Metabolism at a slance (4/E): Part 2

uspbate pathway. This pathway XV duces MAIX*H, which Is an eswirrtlalcrwnxyme tor tatty acid synthesis.2Citrate III ihrcyluKil isacùl by citratelyase

Metabolism of glucose to fatty acids and triacylglycerol27A hrlcfd.-scr1ptl

Ebook Metabolism at a slance (4/E): Part 2A caxbcixvbse. whseli IS a rcRnlatocy csixyme cairroillngfsrty Kid synthesis.In I liter three wars, citrate bis organized Ibe tittUabolK pathway* uf l

iver or fat cells so toot Up.'genesis .-nay proceed.Pentose pbvsplwte pathway generates NADPH for fatty acid synthesis;Tv reiterate, once lie utmiv-ls Ebook Metabolism at a slance (4/E): Part 2

ite enttiiy demands Ilf llw Minna: luce been satisfied, surplus glucose will to stored tn the liter as ghvogen. When the J^y>..z>! tlnriMMŨhill,any Mi

Ebook Metabolism at a slance (4/E): Part 2

qsius jdiicnse uiiiUnlaw will find ehr-ỵjyvrit)l < pulhwerr res-railecx Illi-level ápi-xspliuírustcửlcase. Vndtr these cimmi stances. mcrahnllc. flux

Metabolism of glucose to fatty acids and triacylglycerol27A hrlcfd.-scr1ptl

Ebook Metabolism at a slance (4/E): Part 2thus bypsssmg lite restricliun al rtavritvinxlo-klnasc 1. Because of this bypass, toe pathway Is sometimes referred to as the •tws. w >iKr-»r>'»6|di5<

ie shunt* (Mttiwsr)Otic swr sxoxtant featured" toe ptrtloH- phcnplute pathway IS that 11 pro du. es NAIM*H nail NAIM*. VAI )I'H Is a hydregen .mill de Ebook Metabolism at a slance (4/E): Part 2

rhmd trnm the vfteiiim ninxi. and as such is a pfuasphorylitecl form CÍNAD. the mrss-ctanl functional difference beep that, wherres NADI 1 b used far

Ebook Metabolism at a slance (4/E): Part 2

ATP prodiictcri. MIH’H tariwd tor ratty M»1 SCVCIW.M»>’■: Irthar h.Kyrchal c rtSitiiincTally add xynlhcxiiS and esterificationStaring frcci jduiw. Clu

Metabolism of glucose to fatty acids and triacylglycerol27A hrlcfd.-scr1ptl

Ebook Metabolism at a slance (4/E): Part 2ill ttw I.ytosid. bury arid xynllirwK ix.aulssnl hf the tally K-xl synthase complex, whfch requires ttialunyl CcA. The later rnmhlnecwth the acyl carr

ier protein I ACPI tomrm nulonyl ACP. l-iny (Cxi syotlmis pnKveds v» lilt cycixsl wnes uf nsKlr.uB IS shown ill the chart to tocm padmrtate land a3o s Ebook Metabolism at a slance (4/E): Part 2

tearite. which Is not shew.;. However, M is stnrsd iti sxr.lt) Kills hill .. Irikylglsv.riils (levlw.tid.x'l I’tww are made by}. senes ci esterưicullu

Ebook Metabolism at a slance (4/E): Part 2

n rexlluns that combine Cnrec fatty acid mnlrcuk-s with phvcinl .i-phnsphnte (Sft! < Jtapttr SI.Diagram 27.1: activation of acetyl CoA carboxylase by

Metabolism of glucose to fatty acids and triacylglycerol27A hrlcfd.-scr1ptl

Ebook Metabolism at a slance (4/E): Part 2^os thrsr pnMumtrs In pdyrnrrtre and form tiizyimully acliw fibmtstis Uun levinvlr fatty acjd synthesis. Conrtrscfr. the pradait of file rcoctloA name

ly fatty ccyi I nA ||UVrihwl(>>4j,iK»x dipri1rliiniz.il <1 rrtitw liturlH Is. K wtl.l:s haw sbr'AB Ihil wlwreus xXyncruallun Is way rapid, laluns edv Ebook Metabolism at a slance (4/E): Part 2

> daw wcnn.K ck’p.vymcrlaitlnn b much icw«. with a hilt re or appmr vrttrty 10 niinuln Tre knif.il ufz inivnitr vanm. bul rm rsm I1X nmols OÍ20 mills,

Ebook Metabolism at a slance (4/E): Part 2

rod It has been cac_.>k\1 that a single llwrcdl cccttalns so coo such fikimants.KuttcdlhnunilsmiUhishicilin.iiilissdimw III twniilu 'ic»tpri1ypsy

Metabolism of glucose to fatty acids and triacylglycerol27A hrlcfd.-scr1ptl

Ebook Metabolism at a slance (4/E): Part 2cthWImofwrtsI l jiA sarfsHstw h) Uinta.:.|OVVliU. <1 < tMr. Hurts Ullkn I <; S.STZ ZI SlITIrta win * Str. l-tl,'i ? tf Wn wiry khmi 1*1Glycolysis and

the pentose phosphate pathway collaborate in liver to make fat28Claitctii lo.-pcsto? M.-mcùui of glirose total.Livei is the biochemical factory of the Ebook Metabolism at a slance (4/E): Part 2

bodyl.i.a- Mlh.ỊpMV pin.idn Andpiitn.to!and,>1' uifrSahcdk teiriu. uliteMum, Dad and Grandparents ruled up as one. 'M exkcsive fcuKlbXB inckxk an mpn

Ebook Metabolism at a slance (4/E): Part 2

runt rede In gl-Kteiw ttorecwusB during fettling And last! -g. H* tf»m-tie after a mtac wlitn itarxbnl xhKUM 1» dthwnxl fo Ute brer VW Ute hepatic ixr

Metabolism of glucose to fatty acids and triacylglycerol27A hrlcfd.-scr1ptl

Ebook Metabolism at a slance (4/E): Part 2ulmilin (Chut 2U.1). which arc- exporfed to adipose 13SUC as »WY low density llpnprcrelns (V l.l ft s) r.-« x»n(fi until 110,-drd during raringGlycoly

sis cooperates with the pentose phosphate pathway enabling lipogenesiaUnite mert tissues, lx c-ximpg- masde aid cervcus tlw-c. the lira- dors n:< -svy Ebook Metabolism at a slance (4/E): Part 2

j-ild.-islr HlHIgy llwI.lHltelr .Il ir&lrtkl d.ptlld- ill) |l-in-ilw* «1 i/lally o.kis Io pcOTXk- AT? for tasyrJhxk pathwfers sxh as gkkxacvpsKsB and

Ebook Metabolism at a slance (4/E): Part 2

cr-i» sn-attods '.Wf < lhapwr SR|. Imroad, in Ibis, gfyentysk nperafe* is pwnusr-ship with Ilk penlute phiupl'jse psAJwJr III crtKhce wrtrolf. wlixli

Metabolism of glucose to fatty acids and triacylglycerol27A hrlcfd.-scr1ptl

Ebook Metabolism at a slance (4/E): Part 2v UKrea.scdwdtb.-serntrKlglTcolyiisirtlhcpbtoi.-i-.ioiriictokmas-.- liPFK 1) stage Istti < :tup»r J7;. 'Itii tứnnutiMi to gtytolytk time mr«-» tt-sr J

jo.rtii <-ĩó;spbaií 3 diuulcd llinruip Ute pcnluse rhorptalie paUiwa.y, wỉte.te I. forms glyvcraldehyde .1 petoSfttote Ũ'C tructose 6 phcKpCMte . b.' Ebook Metabolism at a slance (4/E): Part 2

tate of this true . sx l^pl.c-plulx i< d»*. I ill llwstei.oiinPHK-l lwkwGlucose transport into liver cellsGlucose transport bath into (ted state: led

Ebook Metabolism at a slance (4/E): Part 2

out or (fasting) .nor crib Is i4i.ilitAtii'. by the transport prowin GI.UTỈ. which US 4 wry high K tor glucose ciJU rauiulT Fanconi Dkkti syndrome .i

Metabolism of glucose to fatty acids and triacylglycerol27A hrlcfd.-scr1ptl

Ebook Metabolism at a slance (4/E): Part 2fi-tdl* Ikx.w of the in out bfockzde or glucose transport, patents suiter hepatorenal glyco gon Arcuiniilotloai 4 d OMteqntt-d rtúting hypoglycumU. wi

ll e Altai feeding they rapenenee transient hsprtybi-iemto.GlucokinaseAs memorial In < hep to- 16, In liver gl-cose Is pftospMvykiwd tn gjiK-ose 6-tỉ« Ebook Metabolism at a slance (4/E): Part 2

eplnleby gliHvkínKM whxh Im I K„ for ghuvMvf to rnnud'l In other words It has a tow affinity forgjuento and IS deigned to oopowti theemetnous MIIJ>» (

Ebook Metabolism at a slance (4/E): Part 2

upto ISmwii'ri 111 {fiimv arriving ill llv I'.VI via II vlvrwi. pAttúl V till after feeding The ựucvse 6 phosphate » forced can new make giywRea (ueCl

Metabolism of glucose to fatty acids and triacylglycerol27A hrlcfd.-scr1ptl

Ebook Metabolism at a slance (4/E): Part 2 b.-tt»wcci (GKAs) irccandkiiteantkilitKtlcdrugir.'uuA ■ use is i»».l >>led hy »s|.w.!iil>,

b.mriJ willur. lb: b:patoc>te nuikus ÍM.V Gbipirr 2SJ. Rurtose l.pttoiphite nr high itost-pfAitolil cci'kcntrir csts <* jíhKusehlitr>iejỹji>.'kin»sef Ebook Metabolism at a slance (4/E): Part 2

Ka>ílsr«j,Mhforj protein and the iKlhvafuwki-nase Is translocated into the cytosa where It Is stabilized by -rct-xsphnrjtaed l*i»ptKdriK li:t,iinse-'.

Ebook Metabolism at a slance (4/E): Part 2

'ti III r. w ?/i-r<>|dut»<4«ittr I I'FK-JiF J/-hsi (wj.Pentose phosphate pathway and triiscylglycerol synthesis The pentose phosphate pathway presides

Metabolism of glucose to fatty acids and triacylglycerol27A hrlcfd.-scr1ptl

Ebook Metabolism at a slance (4/E): Part 2supply 0Í nxhxed gfotalluune as a ck’ta-cc Against oddalhv carnage (sec I.hifttr IS).

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