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Ebook Pediatric dermatology (4th edition): Part 2

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Nội dung chi tiết: Ebook Pediatric dermatology (4th edition): Part 2

Ebook Pediatric dermatology (4th edition): Part 2

khothu .comChapter 5Nodules and TumorsBernard A. CohenINTRODUCTIONNodules and tumors 111 the skill often raise fears of skill cancer. Fortunately, pri

Ebook Pediatric dermatology (4th edition): Part 2imary skin cancer is extremely rare in childhood, and most infiltrated plaques and tumors are benign

ors of the newborn are reviewed in Chapter 2. while pigmented nevi and melanomas are discussed in Chapter 6. The focus m this chapter is disorders of Ebook Pediatric dermatology (4th edition): Part 2

childhood and adolescence.Several clinical clues, including the depth and color of lesions, aid in developing a differential diagnosis. Superficial gr

Ebook Pediatric dermatology (4th edition): Part 2

owths are readily moved back and forth over the underlying dermis, whereas the overlying epidermis and superficial dermis may slide over deep-seated t

khothu .comChapter 5Nodules and TumorsBernard A. CohenINTRODUCTIONNodules and tumors 111 the skill often raise fears of skill cancer. Fortunately, pri

Ebook Pediatric dermatology (4th edition): Part 2 seborrheic keratoses. Milin. neurofibromas. granuloma annulare, mastocytomas, scars, keloids, xanthomas, xanthogranulomas. nevocellular nevi, and adn

exal tumors involve the superficial and mid dermis Leukemia, lymphoma. melanoma, lipomas, and metastatic solid tumors involve the dermis and or fat an Ebook Pediatric dermatology (4th edition): Part 2

d may extend deep into subcutaneous structures.Histologic diagnosis of 775 superficial lumps excised in childrenTypen(%)Epidermal irxJusion cysts45959

Ebook Pediatric dermatology (4th edition): Part 2

Congenital malformations (pilomatrixoma, lymphangioma, brachial deft cyst)11715Benign neoplasms (neural tumors, lipoma, adnexal tumors)567Benign lesio

khothu .comChapter 5Nodules and TumorsBernard A. CohenINTRODUCTIONNodules and tumors 111 the skill often raise fears of skill cancer. Fortunately, pri

Ebook Pediatric dermatology (4th edition): Part 2ect bite reaction)476Malignant tumors111.4Miscellaneous354Modified from Knight PJ. Remer CB Pediatrics Ì9SÌ. 72:147.Table 5.1 Histologic diagnosis of

775 superficial lumps excised in childrenColor may suggest the specific cell types that comprise various cutaneous nodules and tumors. For instance, y Ebook Pediatric dermatology (4th edition): Part 2

ellow tumors might include laige quantities of fat in a lipoma or hpid-laden histiocytes m xanthomas or xanthogranulomas. Nevocellulai nevi, epidermal

Ebook Pediatric dermatology (4th edition): Part 2

nevi, mastocytomas, and seborrheic keiatosis contain varying amounts of the brown pigment melanin in nevus cells or keratino-cytes Vascular tumors ar

khothu .comChapter 5Nodules and TumorsBernard A. CohenINTRODUCTIONNodules and tumors 111 the skill often raise fears of skill cancer. Fortunately, pri

Ebook Pediatric dermatology (4th edition): Part 2 vascularity.Finally, the diagnosis of certain genodermatoses associated with cutaneous and/or internal malignancies allows the clinician to develop s

trategies for close monitoring Early recognition of malignancy in this setting may be lifesaving Ebook Pediatric dermatology (4th edition): Part 2

nodules and tumors is summarized at the end of the chapter (see Fig. 5.39).SUPERFICIAL NODULES AND TUMORSWartsWarts are benign epidermal tumors produ

Ebook Pediatric dermatology (4th edition): Part 2

ced by human papillomavirus (HPV) infection of the skin and mucous membranes. In children they are seen most commonly on the fingers, hands, and feet.

khothu .comChapter 5Nodules and TumorsBernard A. CohenINTRODUCTIONNodules and tumors 111 the skill often raise fears of skill cancer. Fortunately, pri

Ebook Pediatric dermatology (4th edition): Part 2bly up to several years, and the majority of lesions disappear within 3-5 years. Local trauma promotes inoculation of the virus. Thus, periungual wart

s are common m children who bite their nails 01 pick at hangnails (Fig. 5.3).Investigators have identified over 100 HPV types capable of producing war Ebook Pediatric dermatology (4th edition): Part 2

ts, and many of these organisms produce characteristic lesions in specific locations. For instance, the discrete, round, skin-colored papillomatous pa

Ebook Pediatric dermatology (4th edition): Part 2

pules typical of verruca vulgaris (common warts) are produced by HPV-2 and HPV-4 (Figs 5 1,5.4) The subtle, minimally hypeipigmented fiat warts (verru

khothu .comChapter 5Nodules and TumorsBernard A. CohenINTRODUCTIONNodules and tumors 111 the skill often raise fears of skill cancer. Fortunately, pri

Ebook Pediatric dermatology (4th edition): Part 2he face. arms, and legs (Fig 5.5).Plantar wans are most commonly caused by HPV-1 (Fig. 5 2). Although not proved, the transmission of these warts prob

ably occurs by contact with contaminated, desquamated skin in showers, pool decks, and bathrooms. Although often subtle on the surface, their large si Ebook Pediatric dermatology (4th edition): Part 2

ze may be hidden by a collarette of skin of normal appearance, and the overlying or surrounding calluses often cause pain when the patient walks While

Ebook Pediatric dermatology (4th edition): Part 2

plantar warts may be confused with corns, calluses, or scars, they can be differentiated by their disruption of the normal deimatoglyphics. Character

khothu .comChapter 5Nodules and TumorsBernard A. CohenINTRODUCTIONNodules and tumors 111 the skill often raise fears of skill cancer. Fortunately, pri

Ebook Pediatric dermatology (4th edition): Part 2al cell news syndrome (Gorlin syndrome)Marry basal cell carcinomas (mean age of onset 15 years) on sun-exposed and non-sun-exposed areas; medulloblast

oma; astrocytomaMany basal cell nevi, palmar and plantar pits, jaw cysts, calcification of the falx cerebri, ovarian fibromas, fused ribsAutosomal dom Ebook Pediatric dermatology (4th edition): Part 2

inant PTCHI gene on chromosome 9q22 32Hidrottc ectcderma' dysplasia (Clouston syndrome)Squamous cell carcinoma of palms, soles, nail bedNormal sweatin

Ebook Pediatric dermatology (4th edition): Part 2

g, total alopecia, severe nail dystrophy, palmar and plantar hyperkeratosisAutosomal dominant GJ86 geneAcrokeratosis paraneopiastica (Basex syndrome)B

khothu .comChapter 5Nodules and TumorsBernard A. CohenINTRODUCTIONNodules and tumors 111 the skill often raise fears of skill cancer. Fortunately, pri

Ebook Pediatric dermatology (4th edition): Part 2Xq24-q27DysplastK nevus syndrome (familial, atypical, multiple-mole syndrome)Cutaneous and tftraocular melanoma, lymphoreticular malignancy, sarcomasM

ultiple, large teddoh-brewn moles with irregular borders and non-uniform colors, usually on trunk and arms; familial occurrence of melanomaAutosomal d Ebook Pediatric dermatology (4th edition): Part 2

ominant genetic heterogeneityMultiple hamartoma syndrome (Cowden disease)Carenoma of the breast, colon, thyroidCoexistence of multple, ectodermal, mes

Ebook Pediatric dermatology (4th edition): Part 2

odermal, and endodermal nevoid necplasms; punctate keratoderma of the palms; multiple angiomas lipomasAutosomal dominant PTEN gene on chromosome 10q23

khothu .comChapter 5Nodules and TumorsBernard A. CohenINTRODUCTIONNodules and tumors 111 the skill often raise fears of skill cancer. Fortunately, pri

Ebook Pediatric dermatology (4th edition): Part 2inomas Non-lymphocytic leukemia Pheochromocytoma Carcinoid meningiomasCafe-au-lait spots Skeletal anomalies Neurofibromas lisch noddles Axillary freck

ling XanthogranulomasAutosomal dominant NF 1 gene Sporadic mutations in 50% of casesNeurofibromatosis Type 2Acoustic neuromas Schwannomas Meningiomas Ebook Pediatric dermatology (4th edition): Part 2

AstrocytomasNeurofibromas ± Café-au-ldit macules CataractsAutosomal dominant NF2 gene SCH gene on 22q 11-13.1 Sporadic mutations in 50% of casesMultip

Ebook Pediatric dermatology (4th edition): Part 2

le mucosal neuroma syndrome (multipie endocnne neoplasia Type IIB)Pheochromocytoma, medullary thyroid carcinomaPedunculated nodules on eyelid margins.

khothu .comChapter 5Nodules and TumorsBernard A. CohenINTRODUCTIONNodules and tumors 111 the skill often raise fears of skill cancer. Fortunately, pri

Ebook Pediatric dermatology (4th edition): Part 2Adenocarcinoma of the colon, duodenum; granulosa cell ovarian tumorsPigmented macules on oral mucosa, lips, conjunctivae, digits: mtestxtal polypsAuto

somal dominant SĨK11/LKB1 gene on chromosome 19pl3.3; sporadK mutation m 40%Intestinal polyposis III (Gardner syndrome)Malignant degeneration of colon Ebook Pediatric dermatology (4th edition): Part 2

, adenomatous polyps; sarcomas, thyroid carcinomaPolyps of the colon, small intestine; globoid osteoma of mandible with overling fibromas; epidermoid

Ebook Pediatric dermatology (4th edition): Part 2

cysts; desmods5q21-q22 APC gene

khothu .comChapter 5Nodules and TumorsBernard A. CohenINTRODUCTIONNodules and tumors 111 the skill often raise fears of skill cancer. Fortunately, pri

khothu .comChapter 5Nodules and TumorsBernard A. CohenINTRODUCTIONNodules and tumors 111 the skill often raise fears of skill cancer. Fortunately, pri

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