The logic of chemical synth
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The logic of chemical synth
THE LOGIC OFCHEMICAL SYNTHESISE. J. COREY AND XUE-MIN CHELGDepartment of Chemistry Harvard UniversityCambridge, MassachusettsJOHN WILEY & SONSNew York The logic of chemical synth kChichesterBrisbaneTorontoSingaporePART ONEGENERAL APPROACHES TO THE ANALYSIS OF COMPLEX SYNTHETIC PROBLEMSwww.pdfgrip.comPREFACEThe title of this three-part volume derives from a key theme of the book—the logic underlying the rational analysis of complex synthetic problems. Although the book deals The logic of chemical synth almost exclusively with molecules of biological origin, which are ideal for developing the fundamental ideas of multistep synthetic design because ofThe logic of chemical synth
their architectural complexity and variety, the approach taken is fully applicable to other types of carbon-based structuresPan One outlines the basicTHE LOGIC OFCHEMICAL SYNTHESISE. J. COREY AND XUE-MIN CHELGDepartment of Chemistry Harvard UniversityCambridge, MassachusettsJOHN WILEY & SONSNew York The logic of chemical synth xity. Systematic retrosynthetic analysis and the concurrent use of multiple independent strategies to guide problem solving greatly simplify the task of devising a new synthesis. This way of thinking has been used for more than two decades by one of the authors to teach the analysis of difficult syn The logic of chemical synth thetic problems to many hundreds of chemists. A substantial fraction of the intricate syntheses which have appealed in the literature in recent yearsThe logic of chemical synth
have been produced by these individuals and their students. An effort has been made to present in Part One the essentials of multistrategic retrosynthTHE LOGIC OFCHEMICAL SYNTHESISE. J. COREY AND XUE-MIN CHELGDepartment of Chemistry Harvard UniversityCambridge, MassachusettsJOHN WILEY & SONSNew York The logic of chemical synth as are illustrated by specific chemical examples, a mastery of the principles which are developed in Part One is a prerequisite to expertise in synthetic design. Equally important is a command of the I eactions, structural-mechanistic theory, and reagents of carbon chemistry. The approach in Part On The logic of chemical synth e is complementary to that in courses on synthetic reactions, theoretical carbon chemistry. and general organic chemistry.Part Two. a collection of muThe logic of chemical synth
ltistep syntheses accomplished over a period of more than three decades by the Corey group, provides much integrated information on synthetic methods THE LOGIC OFCHEMICAL SYNTHESISE. J. COREY AND XUE-MIN CHELGDepartment of Chemistry Harvard UniversityCambridge, MassachusettsJOHN WILEY & SONSNew York The logic of chemical synth principles summarized in Part One. Thus. Part Two selves to supplement Part One with emphasis on the methods and reactions of synthesis and also on specific examples of retrosynthetically planned syntheses.The reaction flow-charts of Part Two. and indeed all chemical formulae which appear in this bo The logic of chemical synth ok, were generated by computer. The program used for these drawings was ChemDraw™ adapted for the Macintosh* personal computer by Ml. Stewart RubensteThe logic of chemical synth
in of the Laboratories from the molecular graphics computer program developed by our group at Harvard in the 1960's (E. J. Corey andw T Wipke. ScienceTHE LOGIC OFCHEMICAL SYNTHESISE. J. COREY AND XUE-MIN CHELGDepartment of Chemistry Harvard UniversityCambridge, MassachusettsJOHN WILEY & SONSNew York The logic of chemical synth o the now enormous literature of multistep synthesis. Information on more than five hundred interesting multistep syntheses of biologically derived molecules is included. It is hoped that the structural range and variety of target molecules presented in Part Three will appeal to many chemists.Synthe The logic of chemical synth sis remains a dynamic and central area of chemistry. There are many new principles, strategies and methods of synthesis waiting to be discovered. If tThe logic of chemical synth
his volume is helpful to OIU’ manywww.pdfgrip.comcolleagues 111 the chemical world ill then pursuit of discovery and new knowledge, a major objective THE LOGIC OFCHEMICAL SYNTHESISE. J. COREY AND XUE-MIN CHELGDepartment of Chemistry Harvard UniversityCambridge, MassachusettsJOHN WILEY & SONSNew York The logic of chemical synth etic Analysis1.1Multistep Chemical Synthesis..........................................11.2Molecular Complexity..................................................21.3Thinking About Synthesis..............................................31.4Retrosynthetic Analysis....................................... The logic of chemical synth ........51.5Transforms and Retrons................................................61.6Types of Transforms.............................................The logic of chemical synth
......91.7Selecting Transforms.................................................15THE LOGIC OFCHEMICAL SYNTHESISE. J. COREY AND XUE-MIN CHELGDepartment of Chemistry Harvard UniversityCambridge, MassachusettsJOHN WILEY & SONSNew YorkTHE LOGIC OFCHEMICAL SYNTHESISE. J. COREY AND XUE-MIN CHELGDepartment of Chemistry Harvard UniversityCambridge, MassachusettsJOHN WILEY & SONSNew YorkGọi ngay
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