Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis
Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis
gUNIVERSITYOF WCH.i.ONGONGAUSTRALIAUniversity of WollongongResearch OnlineUniversity of Wollongong Thesis Collection 2017+University of Wollongong The Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis esis Collections2017Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut-brain-adipose axisChi Hoang Lan Dinh L'nnmfty of WollongongUNIXERSITY OF WOLLONGONGCOPYRIGHT WARNINGYou may print oedownlcud ONE copy of this document for the ptapose of yew own research or study Th Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis e University does n« authorise you to copy. connamicate c< otherwise make available electronically to any other person any copyright material cattaineBardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis
d on this site You are reminded of the followwKThis work is copyright Apart han any use permitted under the Copyright Aa 1968, no past of this week magUNIVERSITYOF WCH.i.ONGONGAUSTRALIAUniversity of WollongongResearch OnlineUniversity of Wollongong Thesis Collection 2017+University of Wollongong The Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis legal achat against persons who tn hinge that copyright A r eprodxncc of material that is protected by copyri^it maybe a copyright infringement A court may impose pemlõesand award danages in relation to offewes and infringemaits relating to copyright matsial Higher penalties may apply, and higher d Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis amages may be awarded foe offences and infringements involving the converstm of material into digital or electronic formRecommended CitationDinh, ChiBardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis
Hoang Lan, Bardoxolone methyl for the prevention of obesity foeusing on thy pathology of gutbrain-adipose axis. Doctor of Philosophy thesis. School ofgUNIVERSITYOF WCH.i.ONGONGAUSTRALIAUniversity of WollongongResearch OnlineUniversity of Wollongong Thesis Collection 2017+University of Wollongong The Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis ty of Wollongong. For further information contact the LOW Library research-pub»(Sxtow,cdu.MiUNIVERSITY OF Ị--1 WOLLONGONG iraiFaculty of Science, Medicine and HealthBardoxolone methyl for the prevention of obesity focusing on the pathology of gut-brain-adipose axisCHI HOANG LAN DINHThis thesis is pr Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis esented as part of the requirements for theaward of the degreeDOCTOR OF PHILOSOPHYFromSchool of MedicineUniversity of W ollongong2017ABSTRACTObesity iBardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis
s major health problem today due to its associated complications such as type 2 diabetes, cardiovascular disease and colon cancer. Among these complicgUNIVERSITYOF WCH.i.ONGONGAUSTRALIAUniversity of WollongongResearch OnlineUniversity of Wollongong Thesis Collection 2017+University of Wollongong The Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis s have shown that bardoxolone methyl (BARD), a compound derived from oleanolic acid, is capable of reducing inflammation. This study systematically examined the preventative effects of BARI) on inflammation in various tissues, including visceral white and brown adipose tissues as well as colon tissu Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis es, in a chronic high-fat diet induced obesity mouse model. Furthermore, this project investigated the effect of BARD on brainstem autonomic regulatorBardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis
y centers.Obesity is characterized by increased fat deposition, enlarged adipocytes and fat masses. An overload of energy intake induces an inflammatogUNIVERSITYOF WCH.i.ONGONGAUSTRALIAUniversity of WollongongResearch OnlineUniversity of Wollongong Thesis Collection 2017+University of Wollongong The Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis idenced by a prevention of macrophage invasion as well as increased pro-inflammatory tumor necrosis factor alpha (TNF-a) and IL-Ip in visceral fat tissues such as epidydimal and mesenteric fat masses. BARD also prevented the high-fat diet induced increase in intracellular signaling molecules associa Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis ted with the inflammatory response, including nuclear factor-kappa light-chain enhancer of activated B cells (NF-kB). Akt and ERK. in visceral white aBardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis
dipose tissue. The nervous system, including dopamine- peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-la), ƯCP2. and AMP-acgUNIVERSITYOF WCH.i.ONGONGAUSTRALIAUniversity of WollongongResearch OnlineUniversity of Wollongong Thesis Collection 2017+University of Wollongong The Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis This study showed that BARD stimulates this signaling pathway, from which it prevented excessive deposition of white visceral fat induced by a high-fat diet. Interestingly, this study showed that there was virtually no desensitisation effect following a chronic BARD treatment. Differing from white a Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis dipocytes, brown adipocytes promote energy expenditure, which is beneficial for obesity. This study showed that BARD stimulated sympathetic regulationBardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis
of brainstem autonomic regulatory centers by increasing TH expression and brown adipose tissueibeta 3-adrenergic receptor and PGC-lu signaling. In adgUNIVERSITYOF WCH.i.ONGONGAUSTRALIAUniversity of WollongongResearch OnlineUniversity of Wollongong Thesis Collection 2017+University of Wollongong The Bardoxolone methyl for the prevention of obesity focusing on the pathology of gut brain adipose axis id droplet deposition.gUNIVERSITYOF WCH.i.ONGONGAUSTRALIAUniversity of WollongongResearch OnlineUniversity of Wollongong Thesis Collection 2017+University of Wollongong TheGọi ngay
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