Synthetic Approaches To The New Drugs 2014
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Synthetic Approaches To The New Drugs 2014
Btoorgamc & Medicinal chemistry 24 (2011,) 1937- 198UELSEVIERContents lists available at ScienceDiiectBioorganic & Medicinal Chemistryjournal homepage Synthetic Approaches To The New Drugs 2014 e: www.elsevier.com/locate/bmcReview articleSynthetic approaches to the 2014 new drugsQ QussMaikAndrew c. Hick '-1. Hong X. Ding' Carolyn A. LeverettRobert E. Kynejr.* *. Kevin K.-C. Liu'1-1.Sarah J. Fink1*'', Christopher J. O’Donnell'ÍỴŨCT tVorldwnlr Research utxi Dtvvioọmtni. Croton ỉubvrulcvãn. 4 Synthetic Approaches To The New Drugs 2014 45 Eustern rvini Road. Cĩviurt. CĨ 063W. UniCnl Slate?‘■/Vwrmamdw IHrying) Co.. CỈIÍ. Berjrng1CXXÌ.VÌ. China'Ceiggno Avdomics Resrarrh. MO Camhniff- JSynthetic Approaches To The New Drugs 2014
terirDnve. Camhnrigc. MA 02140. untied State*‘China Novarln Institutes All BóAIedituỉ Reseunft Cu. Ud. Shanjiftai 200131. ơúntr'BwDutu Co.. Lid SftanxBtoorgamc & Medicinal chemistry 24 (2011,) 1937- 198UELSEVIERContents lists available at ScienceDiiectBioorganic & Medicinal Chemistryjournal homepage Synthetic Approaches To The New Drugs 2014 016New drugs introduced to the market every vear represent privileged structures for particular biological targets, these new chemical entities (Nets) provide insight into molecular recognition and also serve as leads for designing future new drugs. 1 his annual review covers the synthesis of thirty Synthetic Approaches To The New Drugs 2014 -seven Nets that were approved for the first time in 2014 and one drug which was approved in 201 i and was not covered in a pieviniis eililiim OÍ thisSynthetic Approaches To The New Drugs 2014
review.«2016 Elsevier Ini. All rights reserved.,'intirriwr.w ABCB1. AlTMundingracccrrc sub-tamily R number 1; ARtX.Tt.All’-hrnding cassette suh-tamilBtoorgamc & Medicinal chemistry 24 (2011,) 1937- 198UELSEVIERContents lists available at ScienceDiiectBioorganic & Medicinal Chemistryjournal homepage Synthetic Approaches To The New Drugs 2014 marc; nil. N,V-ramonytdiim>da70lc: CEDA. Chinese Eond and Dnig Administration; CNS. ceulial Iieivous system: coo. 1.5 cycluocladiene; Cy. cvdoliexyl; Oba. dibeiuylideneacelone; OBU. I ắ diaxabõcvcolu(5.4J31undec 7 ene; DCC. 1.3 dkyduiiexvlcarbudiimide; OCHA dicvcluiiexvlunm>e; EKE. 12 dicliknuellian Synthetic Approaches To The New Drugs 2014 e; DCM. dichluKimelhane; DDQ, 2.3 diddotv 5.6dicsano 1.4 beiuixiuinuoe: 3.4 [HIP. 3.4 dihyrtmpyran; (DHQJjPHAI, hydrrxjuininc l.4-phrhala7ir>Synthetic Approaches To The New Drugs 2014
ther: IMAI), ducopcopyl atodk-arbnxylarc: DIBAI, diisnbiirylaluminiiim hydride: DIPEA. N^-dnsnprapy-Icthylaminc: DMA.dimcthylaccramide: DMAC. dimcrhylBtoorgamc & Medicinal chemistry 24 (2011,) 1937- 198UELSEVIERContents lists available at ScienceDiiectBioorganic & Medicinal Chemistryjournal homepage Synthetic Approaches To The New Drugs 2014 ethyl ester; DMPU. 1.3 dimellivl leltaliydiopyiimidm 2(1/0 one; DMSO. dimethyl sulfoxide: Dif'A diphenylpliusphoivl azide: LDAC. I elliyi 3 (3 dimelhylamitKipcupvlXarbiidiimide; EDC. A' (3 dimelhviaiiũnupivpyl) .V etliylcarbudiimide; re. enantiomeric excels: EMA Emupean Medicine Agency: Er. ethyl: H Synthetic Approaches To The New Drugs 2014 I. European Union: EtOAc. ethyl acctare: GDI. Gaucher disease 1: cm. gcnccypc 1: HAW. o-(7-a74hcn7oma7ol-l-ylJ-N.N.N'X-rerramcrhytiironiiim hexathioroSynthetic Approaches To The New Drugs 2014
phnspharc: Him I. N.N2r2r-rctramcrhy14)-(lH-hcn7nma7ol-l-y1>ironiiim hcxatlimrnphocphare: HCV. heparins < virus; HUM*. histone deacetylase: HOAc. acetBtoorgamc & Medicinal chemistry 24 (2011,) 1937- 198UELSEVIERContents lists available at ScienceDiiectBioorganic & Medicinal Chemistryjournal homepage Synthetic Approaches To The New Drugs 2014 Ac. isopivpvl acetate; IPE. idkiphalliic pulmoiury fibtvsii: I Pt, isoptupvl: Lil IMDS. lillúum liexamethyldisilazide: LUA lilhium diisopropyLunide; mCIÍIA. 3 shimvperoxybenzoic acid: Me. methyl; McCN. acetonitrile: MEK. methyl ethyl ketone: MEMC I. 2-mcrhoxyc-rhoxymcrhyl chloride: 2-McTHE. 2-merhyt Synthetic Approaches To The New Drugs 2014 tcrrahydrociiran; MIRK, methyl icohntyl ketone; Moe. merhoxycarhonyl; Met). mcthancsillronyl chlonde; MsOH. mcrhancsiiltonic acid; MSRA. mcthicilhn-rcSynthetic Approaches To The New Drugs 2014
sisranr SWphyloromis durrws; MIRE, methyl rm-lxnyl ether: MVK. methyl vinyl ketone; MW. tiiknmjve; N Ac Leu. fi acetyl leucine: n BuLi. n bulyllilhiumBtoorgamc & Medicinal chemistry 24 (2011,) 1937- 198UELSEVIERContents lists available at ScienceDiiectBioorganic & Medicinal Chemistryjournal homepage Synthetic Approaches To The New Drugs 2014 N methyl morpholine: NMM0, 4 melhylmocpholine N oxide: NSSAiB. ixinstrucluial SAIB; NsCL2-nirrnbcnc7cnccultonyl chloride: NSC1C. non-small cell lung cancer: (o-rol},l’. rnfl;2-mcrhylphcnyl)phrRphine: IVIjIdhaJj. mcldihcnTylidcncacotoneyiipiltAdiiim: I’d ldppt)X I, C HXIa Jt.l'-bl«(diphcny1phcKphinn) Synthetic Approaches To The New Drugs 2014 tcrrocencJdlchtnrofMlUdiiini(ll). complex with dichlornmerhane: IDE-4, pborphndierrcratc IV: Rf»;OAr)z. palladium acerate: fir. phenyl: PhMe. toluene;Synthetic Approaches To The New Drugs 2014
K3K. phosphatidylinositol 3 kinase: PMDA 1‘taarinaceulicala and Medical Device) Aíỉency: PPAR. peroxisome proliferator activated receptor; ins. pyridBtoorgamc & Medicinal chemistry 24 (2011,) 1937- 198UELSEVIERContents lists available at ScienceDiiectBioorganic & Medicinal Chemistryjournal homepage Synthetic Approaches To The New Drugs 2014 yridine; Red-AI. sodium bis(2-mcrlv>xyerhoxy3ahiminum dihydndc; |KIXSynthetic Approaches To The New Drugs 2014
TFL triHuotoellunol: TfOH, irifluorornethaneMilfonrc acid; TUP. telrahydroruran: TMDS. 1.13,3 letranielhyklisilaxane; TMS. trúnethvlúlvl: INI. tumor nBtoorgamc & Medicinal chemistry 24 (2011,) 1937- 198UELSEVIERContents lists available at ScienceDiiectBioorganic & Medicinal Chemistryjournal homepage Synthetic Approaches To The New Drugs 2014 pyl-1352.4.6-rrioxarriphixphorinanc-2.4.(;-rnoxide-. TRAP, rerrapmpylammomum pemithcnarc: Ts. 4-tnhrcnesultoSynthetic Approaches To The New Drugs 2014
(AC. ElKfcX Sheryl dingjspharmacodia,com (HX. Ding), carnlynAkverctrPphter com (CA leverett), rkync<*ce>gcnocom (RE KyneX kevin liiiíimvarriscom (K.K.Btoorgamc & Medicinal chemistry 24 (2011,) 1937- 198UELSEVIERContents lists available at ScienceDiiectBioorganic & Medicinal Chemistryjournal homepage Synthetic Approaches To The New Drugs 2014 41 3936.’ TH: ♦! 781 541 3749.1 TH: »86 185 0172 5207." TH: »86 21 3175 2858.http.'/idx.doLorgi 10.1016í)hmc.201 b.OJXXM0968 0896.IC 2016 Elsevier Ltd. All rights reserved.1918A. c Ifrrk el olletoorg Med. them. 24 (2016) 193/ I9S0Keywonk:SynthesisNew dni£ molecules New chemical emities MedicineIherj Synthetic Approaches To The New Drugs 2014 peutic AgentsContentsBtoorgamc & Medicinal chemistry 24 (2011,) 1937- 198UELSEVIERContents lists available at ScienceDiiectBioorganic & Medicinal Chemistryjournal homepageBtoorgamc & Medicinal chemistry 24 (2011,) 1937- 198UELSEVIERContents lists available at ScienceDiiectBioorganic & Medicinal Chemistryjournal homepageGọi ngay
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