Interactions between dietary polyphenols and plant cell wall models
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Interactions between dietary polyphenols and plant cell wall models
The University Of QueenslandAUSTRALIAINTERACTIONS BETWEEN DIETARY POLYPHENOLSAND PLANT CELL WALL MODELSAnh Dao Till PhanB.Eng. Food Technology (Can Th Interactions between dietary polyphenols and plant cell wall models ho University, Vietnam)MSc. Food Science and Technology (University of Copenhagen, Denmark)J thesis- submitted for the degree of Doctor of Philosophy atThe University of Queensland in 2016ARC Centre of Excellence in Plant Cell Walls.Centre for Nutrition and Food Sciences,Queensland Alliance for Agri Interactions between dietary polyphenols and plant cell wall models culture and Food InnovationAbstractrhe nutritional and health benefits of polyphenols ill protecting humans from the risk of chronic diseases (e.g. caInteractions between dietary polyphenols and plant cell wall models
rdiovascular disease, cancers) are now well established from both epidemiological and intervention studies. Recently, there has been emerging interestThe University Of QueenslandAUSTRALIAINTERACTIONS BETWEEN DIETARY POLYPHENOLSAND PLANT CELL WALL MODELSAnh Dao Till PhanB.Eng. Food Technology (Can Th Interactions between dietary polyphenols and plant cell wall models th-promoting effects of polyphenols, These interactions may have a major role in controlling the bioaccessibility of polyphenols by modulating the release of polyphenols in the upper digestive tract, or delivering bound polyphenols to the colon, for further release and metabolism by the resident mic Interactions between dietary polyphenols and plant cell wall models robiota.This project addresses important aspects related to polyphenol bioaccessibility through investigations of: (/■) the interactions between diverInteractions between dietary polyphenols and plant cell wall models
se polyphenols and cellulose, a main dietary fibre component, and determination of the mechanism behind such interactions; (Ú) the effects of environmThe University Of QueenslandAUSTRALIAINTERACTIONS BETWEEN DIETARY POLYPHENOLSAND PLANT CELL WALL MODELSAnh Dao Till PhanB.Eng. Food Technology (Can Th Interactions between dietary polyphenols and plant cell wall models ectivity of diverse polyphenols to different PCW components (cellulose, hemicellulose, pectin), and identification of factors that influence such binding selectivity: and (?y) the release and metabolism of polyphenols associated with PCW during in vitro gastrointestinal digestion and colonic ferment Interactions between dietary polyphenols and plant cell wall models ation.A systematic understanding of the interactions between polyphenols and PCWs and the mechanisms behind such interactions has been developed. BindInteractions between dietary polyphenols and plant cell wall models
ing kinetics and binding isotherm studies of diverse polyphenols to cellulose and other PCW components permit quantification of the binding cxtcnls/raThe University Of QueenslandAUSTRALIAINTERACTIONS BETWEEN DIETARY POLYPHENOLSAND PLANT CELL WALL MODELSAnh Dao Till PhanB.Eng. Food Technology (Can Th Interactions between dietary polyphenols and plant cell wall models capacities achieved were in the range of 20-60% of the PCW mass, and the apparent maximum binding capacity was predicted to be 30-150% PCW mass, depending on the polyphenol molecules and the PCW components. This implies that a high amount of ingested polyphenols might be present in the human digesti Interactions between dietary polyphenols and plant cell wall models ve tract in non-bioacccssiblc forms, if the interactions with PCWs arc relatively stable under gastric and small intestinal conditions.By employing aInteractions between dietary polyphenols and plant cell wall models
model system of bacterial cellulose-based composites which have previously been shown to represent important features of the chemical organization andThe University Of QueenslandAUSTRALIAINTERACTIONS BETWEEN DIETARY POLYPHENOLSAND PLANT CELL WALL MODELSAnh Dao Till PhanB.Eng. Food Technology (Can Th Interactions between dietary polyphenols and plant cell wall models define the differences in binding behaviours of polyphenols to various PCWconstituents. The binding selectivity of diverse polyphenols to different PCW components was determined and quantified, with the binding capacities following the order of Cellulose>Cellulose-arabinoxylan>Cellulose-xyloglucan>C Interactions between dietary polyphenols and plant cell wall models ellulose-pectin-'Apple cell walls, for the binding of (+/-)-catechin and ferulic acid, while Cellulose-pectin composites showed the greatest binding fInteractions between dietary polyphenols and plant cell wall models
or cyanidin-3-glucoside (Cya-3-glc). In addition, both intrinsic factors (e.g. the chemical characteristics of polyphenols, the chemical organization The University Of QueenslandAUSTRALIAINTERACTIONS BETWEEN DIETARY POLYPHENOLSAND PLANT CELL WALL MODELSAnh Dao Till PhanB.Eng. Food Technology (Can Th Interactions between dietary polyphenols and plant cell wall models are major factors in modulating the binding process in a food system and/or under human digestion conditions, suggesting the simultaneous and complex effects of multiple factors on the binding rates and extents of polyphenols.This project observed the incomplete release of polyphenols associated wit Interactions between dietary polyphenols and plant cell wall models h cellulose and apple cell walls under gastrointestinal digestion conditions, with the most release occurring in the gastric phase as a result of theInteractions between dietary polyphenols and plant cell wall models
effects of the acidic environment on polyphenol PCW interactions. There was limited release of bound (+/-)-catechin (20-35%) and bound Cỵa-3-glc (30-6The University Of QueenslandAUSTRALIAINTERACTIONS BETWEEN DIETARY POLYPHENOLSAND PLANT CELL WALL MODELSAnh Dao Till PhanB.Eng. Food Technology (Can Th Interactions between dietary polyphenols and plant cell wall models delivered to the colon for further release and metabolism during the fermentation by colonic microbiota.In order to investigate the potential release and metabolism of polyphenols in the large intestine, a 72h in vino colonic fermentation was conducted for the complexes of polyphenols with apple ce Interactions between dietary polyphenols and plant cell wall models ll walls (ACW) or bacterial cellulose (BC). using a pig faecal inoculum. All ACW substrates were fermented faster than the BC substrates, as evidencedInteractions between dietary polyphenols and plant cell wall models
by the significantly ịp<0.05) higher production of gas and short chain fatty acids. Bound polyphenols were partly released (22-60%) by 2h. followed bThe University Of QueenslandAUSTRALIAINTERACTIONS BETWEEN DIETARY POLYPHENOLSAND PLANT CELL WALL MODELSAnh Dao Till PhanB.Eng. Food Technology (Can Th Interactions between dietary polyphenols and plant cell wall models techin. The released polyphenols were completely metabolized by pig feacal microbiota via various proposed pathways, leading to the formation of a small number of possible metabolites. Although the presence of different PCWs did not show an alteration in the metabolic pathways mediated by pig faecal Interactions between dietary polyphenols and plant cell wall models bacteria for the three polyphenols studied, polyphenols associated with PCWs underwentfaster microbial metabolism compared to the control sample withInteractions between dietary polyphenols and plant cell wall models
out any PCW. The results suggest the essential role of PCW in the transportation of polyphenol precursors to the colon, and subsequent enhancement of The University Of QueenslandAUSTRALIAINTERACTIONS BETWEEN DIETARY POLYPHENOLSAND PLANT CELL WALL MODELSAnh Dao Till PhanB.Eng. Food Technology (Can Th Interactions between dietary polyphenols and plant cell wall models mposed of my original work, and contains no material previously published or written by another person except where due reference has been made in the text. 1 have clearly stated the contribution by others to jointly-authored works that I have included in my thesis.Ĩ have clearly stated the contribu Interactions between dietary polyphenols and plant cell wall models tion of others to my thesis as a whole, including statistical assistance, survey design, data analysis, significant technical procedures, professionalInteractions between dietary polyphenols and plant cell wall models
editorial advice, and any other original research work used or reported in my thesis, rhe content of my thesis is the result of work Ĩ have carried oThe University Of QueenslandAUSTRALIAINTERACTIONS BETWEEN DIETARY POLYPHENOLSAND PLANT CELL WALL MODELSAnh Dao Till PhanB.Eng. Food Technology (Can Th Interactions between dietary polyphenols and plant cell wall models for the award of any other degree or diploma in any university or other tertiary’ institution. Ĩ have clearly slated which parts of my thesis, if any. have been submitted to qualify for another award.I acknowledge that an electronic copy of my thesis must be lodged with the University Library and. s Interactions between dietary polyphenols and plant cell wall models ubject to the policy and procedures of The University of Queensland, the thesis be made available for research and study in accordance with the CopyriInteractions between dietary polyphenols and plant cell wall models
ght Act 1968 unless a period of embargo has been approved by the Dean of the Graduate School.I acknowledge that copyright of all material contained inThe University Of QueenslandAUSTRALIAINTERACTIONS BETWEEN DIETARY POLYPHENOLSAND PLANT CELL WALL MODELSAnh Dao Till PhanB.Eng. Food Technology (Can Th Interactions between dietary polyphenols and plant cell wall models eproduce material in this thesis.Publications during candidature:Peer-reviewed papers:•PHAN. A. D. T.. NETZEL. G.. WANG. D.. FLANAGAN. B. M.. D'ARCY. B R. & GIDLEY.M. J. 2015. Binding of dietary polyphenols to cellulose: Structural and nutritional aspects. Food Chemistry. 171, 388-396. (Incorporated Interactions between dietary polyphenols and plant cell wall models in Chapter 3)•PHAN. A. D. T.. D'ARCY. B. R. & GIDLEY. M. J. 2016. Polyphenol-cellulose interactions: effects of pH, temperature and salt. InternationInteractions between dietary polyphenols and plant cell wall models
al Journal of Food Science and Technology. 51, 203-211. (Incorporated in Chapter 4)Conference abstracts and presentations:•PHAN. A. D. T., NETZEL. G.,The University Of QueenslandAUSTRALIAINTERACTIONS BETWEEN DIETARY POLYPHENOLSAND PLANT CELL WALL MODELSAnh Dao Till PhanB.Eng. Food Technology (Can Th Interactions between dietary polyphenols and plant cell wall models n 2014 ", 365-366. 2fh International Conference on Polyphenols and &h Tannin Joint Conference. Nagoya University. Japan. 2-6,h September 2014 (Poster presentation).•PHAN. A. D. T.. NETZEL. G., D ARCY. B. R. & GIDLEY. M. J. 2013. The roles of cellulose in controlling the bioaccessibility of dietary p Interactions between dietary polyphenols and plant cell wall models olyphenols. Nutrition Society of Australia dt Nutrition Society of New Zealand Joint Annual Scientific Meeting. Brisbane. 4-6th December 2013 (Oral prInteractions between dietary polyphenols and plant cell wall models
esentation).Gọi ngay
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