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Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

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Nội dung chi tiết: Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

•RM.ITUNIVERSITYInvestigation into the Modulation of Circadian Clock Proteins by Dietary Compounds and Small MoleculesA thesis submitted in fulfilment

Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules t of the requirements for the degree of Master of ScienceElcni PitsillouB.Sc. (Hons) Pathology, University of MelbourneSchool of ScienceCollege of Sci

ence. Technology. Engineering and MathsRM 11 University44621Declaration1 certify that except where due acknowledgement has been Uladc. this research i Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

s that of the author alone: rhe content of this research submission is the result of work which has been carried out since the official commencement d

Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

ate of the approved research program; any editorial work, paid or unpaid, carried out by a third party is acknowledged: and. ethics procedures and gui

•RM.ITUNIVERSITYInvestigation into the Modulation of Circadian Clock Proteins by Dietary Compounds and Small MoleculesA thesis submitted in fulfilment

Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules other university or institution, unless approved for a joint-award with another institution, and acknowledge that no part of this work will, in the fu

ture, be used in a submission in my name, for any other qualification in any university or other tertian' institution without the prior approval of th Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

e University, and where applicable, any partner institution responsible for the joint-award of this degree.I acknowledge that copyright of any publish

Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

ed works contained within this thesis resides with the copyright holder(s) of those works.I give permission for the digital version of my research sub

•RM.ITUNIVERSITYInvestigation into the Modulation of Circadian Clock Proteins by Dietary Compounds and Small MoleculesA thesis submitted in fulfilment

Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules trict access for a period of timeI acknowledge the support 1 have received for my research through the provision of an Australian Government Research

Training Program Scholarship.F.leni Pitsillou03/03 202211AcknowledgementsFirstly. Ĩ would like to thank Dr Andrew Hung and Dr Toni Karagiannis for the Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

ir guidance and support over the past few years. Then wolds of encouragement and feedback have been invaluable. Ĩ appreciate the opportunity to work o

Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

n this project. T would also like to thank Julia Liang for her ongoing suppoll and for all the knowledge that she has pio\ ided. Thank you to Raymond

•RM.ITUNIVERSITYInvestigation into the Modulation of Circadian Clock Proteins by Dietary Compounds and Small MoleculesA thesis submitted in fulfilment

Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules wledge McCord Research (Iowa. USA) for financial support and Reaction Biology (QPatch: Malvern. PA. USA) for performing rhe patch clamp assays as desc

ribed m Chapter 2. 1 would also like to acknowledge the generous allocation of computational resources provided by the National Computing Infrastructu Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

re (NCI), Pawsey Super coniput mg Centre 111 Australia (funded by the Australian Govennncnt). the Spartan High Performance Computing service (Universi

Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

ty of Melbourne), and the Partnership for Advanced Computing Ill Europe (PRACE) for awarding the access to P1Z Daint, hosted at rhe Swiss National Sup

•RM.ITUNIVERSITYInvestigation into the Modulation of Circadian Clock Proteins by Dietary Compounds and Small MoleculesA thesis submitted in fulfilment

Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules of years and for then understanding.IllTable of contentsDeclaration................................................................11Acknowledgements

..........................................................iiiTable of contents..........................................................IVList of abbr Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

eviations.....................................................VIIList of figures.............................................................XList of

Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules

tables............................................................XVIAbstract....................................................................1Chap

•RM.ITUNIVERSITYInvestigation into the Modulation of Circadian Clock Proteins by Dietary Compounds and Small MoleculesA thesis submitted in fulfilment

Masters thesis of science investigation into the modulation of circadian clock proteins by dietary compounds and small molecules mmalian transcription-translation feedback loops....................5

•RM.ITUNIVERSITYInvestigation into the Modulation of Circadian Clock Proteins by Dietary Compounds and Small MoleculesA thesis submitted in fulfilment

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