comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches
comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches
Research ArticleThe Journal of CorResearch in Systems NeuroscienceDOI 10.1002/cne.23733Comprehensive expression map of transcription regulators in the comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic nichese adult zebrafishtelencephalon reveals distinct neurogenic nichesNicolas Diotel12*. Rebecca Rodríguez Viales13*, Olivier Armant1. Martin Marz14, MarcoFerg1, Sepand Rastegar15 and Uwe strahle151Institute of Toxicology and Genetics. Karlsruhe Institute of Technology, Campus Nord.PO box. Karlsruhe, Ger comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic nichesmany2Current address: Inserm U1188, Université de La Reunion. Plateforme CYROI, Saint-Denis de La Reunion. FRANCE3Current address: Centre for Pulmonarcomprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches
y Hypertension Thoraxclinic and Institute of Human Genetics, University of Heidelberg. Im Neuenheimer Feld 366, Germany4Current address: Department ofResearch ArticleThe Journal of CorResearch in Systems NeuroscienceDOI 10.1002/cne.23733Comprehensive expression map of transcription regulators in the comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic nichespand.rastegar@kit.edu) and Uwe străhle (uwe.straehle@kit edu)* Authors contributed equally to this workKey words: zebrafish, forebrain, adult neurogenesis, transcription regulator, expression pattern, databaseRunning title:Atlas of expression of transcriptional regulators in the telencephalon of adu comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic nicheslt zebrafishThis article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagincomprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches
ation and proofreading process which may lead to differences between this version and the Version of Record Please cite this article as an Accepted ArResearch ArticleThe Journal of CorResearch in Systems NeuroscienceDOI 10.1002/cne.23733Comprehensive expression map of transcription regulators in the comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic nichescted by copyright. All lights reservedJournal of Comparative NeurologyAbstractThe zebrafish has become a model to study adult vertebrate neurogenesis. In particular, the adult telencephalon has been an intensely studied structure in the zebrafish brain. Differential expression of transcriptional reg comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic nichesulators (TRs) is a key feature of development and tissue homeostasis Here, we report an expression map of 1202 TR genes in the telencephalon of adultcomprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches
zebrafish. Our results are summarized in a database with search and clustering functions to identify genes expressed in particular regions of the teleResearch ArticleThe Journal of CorResearch in Systems NeuroscienceDOI 10.1002/cne.23733Comprehensive expression map of transcription regulators in the comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic nichesnique and complex patterns of expression and could thus not be grouped into distinct classes. The neurogenic ventricular regions express overlapping but distinct sets of TR genes suggesting regional differences in the neurogenic niches in the telencephalon. In summary, the small telencephalon of the comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches zebrafish shows a remarkable complexity in TR gene expression.JI I ll/TEM rrvQ2John Wiley & SonsThis article is protected by copyright. All lights recomprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches
served.Pag© 3 of 159Journal of Comparative NeurologyIntroductionDifferential transcription of genes is a mechanism underlying a wide variety of cellulResearch ArticleThe Journal of CorResearch in Systems NeuroscienceDOI 10.1002/cne.23733Comprehensive expression map of transcription regulators in the comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches transcriptional regulators (TRs). Neurogenesis is based on regulatory cascades of TRs. eventually leading to differentiation of the many distinct neuronal cell types. Differential expression of TR genes is a key feature not only during development but also in the maintenance and function of the com comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic nichesplex structures of the central nervous system (CNS) in the adult.The zebrafish genome encodes 3302 putative TR genes representing - 12.7% of total procomprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches
tein coding genes (Armant et al., 2013). Of these, about 2600 genes are detectably expressed in the one day old embryo (Armant et al., 2013). The largResearch ArticleThe Journal of CorResearch in Systems NeuroscienceDOI 10.1002/cne.23733Comprehensive expression map of transcription regulators in the comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic nichess such as development and body homeostasis. TRs affect transcription of genes at different levels from influencing the state of chromatin, to interaction with DNA regulatory elements to the modulation of the general transcription machinery by cell-specific employment of different components. Very fr comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic nichesequently, TR genes are subject to differential transcription themselves thereby serving specific regulatory roles in the regionally restricted hierarccomprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches
hical steps of organ development. In the developing CNS. for example. TRs are expressed in distinct territories such as the prosomeres of the forebraiResearch ArticleThe Journal of CorResearch in Systems NeuroscienceDOI 10.1002/cne.23733Comprehensive expression map of transcription regulators in theResearch ArticleThe Journal of CorResearch in Systems NeuroscienceDOI 10.1002/cne.23733Comprehensive expression map of transcription regulators in theGọi ngay
Chat zalo
Facebook