Microenvironmental Forces Regulate Notch Signaling Through Integr
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Microenvironmental Forces Regulate Notch Signaling Through Integr
MICROENVIRONMENTAL FORCES REGULATE NOTCH SIGNALINGTHROUGH INTEGRINSbyMichael Allen DetweilerA thesis submitted in partial fulfillment of the requireme Microenvironmental Forces Regulate Notch Signaling Through Integrents for the degree of Master of Science in Biology Boise State University43435BOISE STATE UNIVERSITY GRADUATE COLLEGEDEFENSE COMMITTEE AND FINAL READING APPROVALS of the thesis submitted by Michael Allen DetweilerThesis Title: Microenvironmental Forces Regulate Notch Signaling Through Tntegrins Dat Microenvironmental Forces Regulate Notch Signaling Through Integre of Final Oral Examination: 25 October 2018The following individuals read and discussed the thesis submitted by student Michael Allen Detweiler, andMicroenvironmental Forces Regulate Notch Signaling Through Integr
they evaluated his presentation and response to questions during the final oral examination. They found that the student passed the final oral examinaMICROENVIRONMENTAL FORCES REGULATE NOTCH SIGNALINGTHROUGH INTEGRINSbyMichael Allen DetweilerA thesis submitted in partial fulfillment of the requireme Microenvironmental Forces Regulate Notch Signaling Through Integre final reading approval of the thesis was granted by Allan Albig. Ph.D.. Chair of the Supervisory Committee. The thesis was approved by the Graduate College.ACKNOWLEDGEMENTSFirst and foremost. I would like to thank my advisor. Dr. Allan Albig, for being an incredible mentor and friend. With his gui Microenvironmental Forces Regulate Notch Signaling Through Integrdance and moral support. I have been able to fully understand and integrate the ethics and investigative nature of science. I would also like to thankMicroenvironmental Forces Regulate Notch Signaling Through Integr
Dr. Brad Morrison and Dr. Troy Rohn for being on my thesis committee and for their very helpful suggestions.Through my time at Boise State I have hadMICROENVIRONMENTAL FORCES REGULATE NOTCH SIGNALINGTHROUGH INTEGRINSbyMichael Allen DetweilerA thesis submitted in partial fulfillment of the requireme Microenvironmental Forces Regulate Notch Signaling Through Integrya, Jordan Munroe. Shelby Havel, and Dr. Allison Myamoto.I would also like to give thanks to the National Institute of Health for providing the Rinding to support this thesis.ivABSTRACTThe extracellular microenvironment contributes significantly to a cell’s function and behavior. For instance, cell- Microenvironmental Forces Regulate Notch Signaling Through Integrcell interactions, cell-substrate interactions, and physical forces are all factors of the extracellular environment that can alter cellular behavior.Microenvironmental Forces Regulate Notch Signaling Through Integr
Cells can receive these signals and forces through various membrane channels and receptors that transmit the signals from the extracellular to the inMICROENVIRONMENTAL FORCES REGULATE NOTCH SIGNALINGTHROUGH INTEGRINSbyMichael Allen DetweilerA thesis submitted in partial fulfillment of the requireme Microenvironmental Forces Regulate Notch Signaling Through Integrnaling can occur through a variety of extracellular stimuli including hyperglycemia, hypoxia, multiple growth factors, fluid shear stress, and extracellular matrix (ECM) composition. Although Notch activation through ligand interactions with adjacent cells have been well established, non-canonical N Microenvironmental Forces Regulate Notch Signaling Through Integrotch signaling through the microenvironment is poorly understood. Previous evidence suggests a novel activation of Notch signaling through an integrinMicroenvironmental Forces Regulate Notch Signaling Through Integr
pathway, proposing Notch as a microenvironmental sensor. Integrins are cell membrane receptors that are mainly recognized for cell-ECM attachment andMICROENVIRONMENTAL FORCES REGULATE NOTCH SIGNALINGTHROUGH INTEGRINSbyMichael Allen DetweilerA thesis submitted in partial fulfillment of the requireme Microenvironmental Forces Regulate Notch Signaling Through Integrce integrins have been shown to regulate Notch signaling and both exhibit a response to fluid shear stress, we hypothesized that Notch signaling responds to fluid shear stress through integrin activation. To test this, we compared Notch activation following exposure to fluid shear stress and Notch a Microenvironmental Forces Regulate Notch Signaling Through Integrctivation following shear stress after inhibiting integrin function. Our data confirms that Notch activation is significantlyVupregulated from fluid sMicroenvironmental Forces Regulate Notch Signaling Through Integr
hear stress compared to a static control and inhibiting integrin function attenuates this response, suggesting integrins are required for Notch’s upreMICROENVIRONMENTAL FORCES REGULATE NOTCH SIGNALINGTHROUGH INTEGRINSbyMichael Allen DetweilerA thesis submitted in partial fulfillment of the requireme Microenvironmental Forces Regulate Notch Signaling Through Integr during conditions of fibrosis, we hypothesized that Notch signaling will be regulated by varying degrees of ECM stiffness through integral activation. To investigate this hypothesis, we cultured cells on hydrogels with multiple levels of stiffness and measured Notch signaling. Our results indicate Microenvironmental Forces Regulate Notch Signaling Through Integrthat like shear stress. Notch signaling is influenced by ECM stiffness. Collectively our results indicate that Notch signaling is regulated through miMicroenvironmental Forces Regulate Notch Signaling Through Integr
croenvironmental forces like fluid shear stress and ECM stiffness and is regulated through integrins. This furthers our understanding of the variationMICROENVIRONMENTAL FORCES REGULATE NOTCH SIGNALINGTHROUGH INTEGRINSbyMichael Allen DetweilerA thesis submitted in partial fulfillment of the requireme Microenvironmental Forces Regulate Notch Signaling Through Integrr results improve our knowledge of Notch signaling in pathological conditions of the microenvironment including abnormal shear stress (e.g. atherosclerosis) and tissue stiffness (e.g. fibrosis).VI Microenvironmental Forces Regulate Notch Signaling Through IntegrMICROENVIRONMENTAL FORCES REGULATE NOTCH SIGNALINGTHROUGH INTEGRINSbyMichael Allen DetweilerA thesis submitted in partial fulfillment of the requiremeGọi ngay
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