Ebook High-Yield biochemistry (3rd edition): Part 2
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: Ebook High-Yield biochemistry (3rd edition): Part 2
Ebook High-Yield biochemistry (3rd edition): Part 2
■::&zAmino Add Metabolismo Functions of Amino AcidsA.The synthesis of new proteins requires amino acids. The primary source of amino acids is dietary Ebook High-Yield biochemistry (3rd edition): Part 2 protein. Breakdown of tissue proteins also provides amino acids.B.Amino acids provide nitrogen-containing substrates for the biosynthesis of:1Noncssential amino acids2Purines and pyrimidines3Porphyrins4Neurotransmitters and hormonesc. The carbon skeletons of the surplus amino acids not needed (or s Ebook High-Yield biochemistry (3rd edition): Part 2ynthetic pathways serve as fuel. They may be:1Oxidized in the tricarboxylic acid (TCA) cycle to produce energy.2Used as substrates for gluconeogenesisEbook High-Yield biochemistry (3rd edition): Part 2
.3Used as substrates for fatty acid synthesis.o Removal of Amino Acid NitrogenA.DEAMINATION, the first step in metabolizing surplus amino acids, yield■::&zAmino Add Metabolismo Functions of Amino AcidsA.The synthesis of new proteins requires amino acids. The primary source of amino acids is dietary Ebook High-Yield biochemistry (3rd edition): Part 2(transaminase) and glutamate dehydrogenase (Figure 7-1).c. The appearance of aspartate aminotransferase (AST) or alanine aminotransferase (ALT) in the blood is an indication of tissue damage, especially cardiac muscle (AST) and the liver (AST and ALT).o Urea Cycle and Detoxification of \ll+A.NH| is Ebook High-Yield biochemistry (3rd edition): Part 2toxic to the human body, particularly the central nervous system (CNS).B.NHỊ IS CONVERTED TO UREA m the liver via the urea cycle. Urea is excreted inEbook High-Yield biochemistry (3rd edition): Part 2
the urine (Figure 7-2).4546 CHAPTER 7a-KetoglutarateL-Glutamatea-Ketoglutarate• Figure 7-1 Deamination of an amino acid by the sequential action of an■::&zAmino Add Metabolismo Functions of Amino AcidsA.The synthesis of new proteins requires amino acids. The primary source of amino acids is dietary Ebook High-Yield biochemistry (3rd edition): Part 2te, Ộ - activation; 6 - inhibition; italicized terms - enzyme names.c. IN PERIPHERAL TISSUES, detoxification of NH:» which is ultimately converted to urea in the liver, occurs by different mechanisms.1In most tissues, the enzyme glutamine synthetase incorporates NH* into glutamate to form glutamine, Ebook High-Yield biochemistry (3rd edition): Part 2 which is carried by the circulation to the liver. There the enzyme glutaminase hydrolyzes glutamine back to NH| and glutamate.2In skeletal muscle, seEbook High-Yield biochemistry (3rd edition): Part 2
quential action of the enzymes glutamate dehydrogenase and glutamate-pyruvate aminotransferase can lead to the incorporation of NHị into alanine.a.The■::&zAmino Add Metabolismo Functions of Amino AcidsA.The synthesis of new proteins requires amino acids. The primary source of amino acids is dietary Ebook High-Yield biochemistry (3rd edition): Part 2 gluconeogenesis.c.The glucose enters the circulation and is carried back to the muscle where it enters glycolysis and generates pyruvate.d.This is called the glucose-alanine cycle.D.HYPERAMMONEMIA1This condition may be caused by insufficient removal of NH*, resulting from disorders that involve one Ebook High-Yield biochemistry (3rd edition): Part 2 of the enzymes in the urea cycle.2Blood ammonia concentrations above the normal range (30 to 60 p.M) may cause ammonia intoxication.3Ammonia intoxicaEbook High-Yield biochemistry (3rd edition): Part 2
tion can lead to mental retardation, seizure, coma, and death.4Enzyme defects■::&zAmino Add Metabolismo Functions of Amino AcidsA.The synthesis of new proteins requires amino acids. The primary source of amino acids is dietary ■::&zAmino Add Metabolismo Functions of Amino AcidsA.The synthesis of new proteins requires amino acids. The primary source of amino acids is dietaryGọi ngay
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