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Ebook Marks'' essentials of medical biochemistry a clinical approach (2nd edition): Part 2

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Nội dung chi tiết: Ebook Marks'' essentials of medical biochemistry a clinical approach (2nd edition): Part 2

Ebook Marks'' essentials of medical biochemistry a clinical approach (2nd edition): Part 2

SECTION FIVE Carbohydrate MetabolisiBasic Concepts in the Regulation ofFuel Metabolism by Insulin, Glucagon, and 21 Other HormonesCHAPTER OUTLINEI.MET

Ebook Marks'' essentials of medical biochemistry a clinical approach (2nd edition): Part 2TABOLIC HOMEOSTASISII.MAJOR HORMONES OF METABOLIC HOMEOSTASISIII.SYNTHESIS AND RELEASE OF INSULIN AND GLUCAGONA.Endocrine pancreasB.Synthesis and secr

etion of insulinc. Stimulation and inhibition of insulin releaseD. Synthesis and secretion of glucagonKEY POINTSIV.MECHANISMS OF HORMONE ACTIONA.Signa Ebook Marks'' essentials of medical biochemistry a clinical approach (2nd edition): Part 2

l transduction by hormones that bind to plasma membrane receptors1Signal transduction by insulin2Signal transduction by glucagonB.Signal transduction

Ebook Marks'' essentials of medical biochemistry a clinical approach (2nd edition): Part 2

by cortisol and other hormones that interact with intracellular receptorsc. Signal transduction by epinephrine and norepinephrine■Insulin and glucagon

SECTION FIVE Carbohydrate MetabolisiBasic Concepts in the Regulation ofFuel Metabolism by Insulin, Glucagon, and 21 Other HormonesCHAPTER OUTLINEI.MET

Ebook Marks'' essentials of medical biochemistry a clinical approach (2nd edition): Part 2te varying carbohydrate intake during the day.■Glucose homeostasis is the maintenance of constant blood glucose levels.■If dietary intake of all fuels

is in excess of immediate need, it is stored as either glycogen or fat.■Appropriately stored fuels are mobilized when demand requires.■Insulin is rel Ebook Marks'' essentials of medical biochemistry a clinical approach (2nd edition): Part 2

eased in response to carbohydrate ingestion and promotes glucose utilization as a fuel and glucose storage as fat and glycogen.■Glucagon is decreased

Ebook Marks'' essentials of medical biochemistry a clinical approach (2nd edition): Part 2

in response to a carbohydrate meal and elevated during fasting.■Glucagon promotes glucose production via glycogenolysis (glycogen degradation} and glu

SECTION FIVE Carbohydrate MetabolisiBasic Concepts in the Regulation ofFuel Metabolism by Insulin, Glucagon, and 21 Other HormonesCHAPTER OUTLINEI.MET

Ebook Marks'' essentials of medical biochemistry a clinical approach (2nd edition): Part 2e the release of fatty acids from adipose tissue.■Insulin secretion is regulated principally by blood glucose levels.■Glucagon release is regulated pr

incipally through suppression by glucose and by insulin.■Glucagon acts by binding to a receptor on the cell surface, which stimulates the synthesis of Ebook Marks'' essentials of medical biochemistry a clinical approach (2nd edition): Part 2

the intracellular second messenger, cAMP.■cAMP activates protein kinase A, which phosphorylates key regulatory enzymes, activating some and inhibitin

Ebook Marks'' essentials of medical biochemistry a clinical approach (2nd edition): Part 2

g others.■Insulin acts via a receptor tyrosine kinase and leads to the dephosphorylation of the key enzymes phosphorylated in response to glucagon.329

SECTION FIVE Carbohydrate MetabolisiBasic Concepts in the Regulation ofFuel Metabolism by Insulin, Glucagon, and 21 Other HormonesCHAPTER OUTLINEI.MET

Ebook Marks'' essentials of medical biochemistry a clinical approach (2nd edition): Part 2od has on its own rale of metabolism. The concentration ol fatly acids in the blood is the major factor determin-

SECTION FIVE Carbohydrate MetabolisiBasic Concepts in the Regulation ofFuel Metabolism by Insulin, Glucagon, and 21 Other HormonesCHAPTER OUTLINEI.MET

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