Ebook Netter’s essential biochemistry: Part 2
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: Ebook Netter’s essential biochemistry: Part 2
Ebook Netter’s essential biochemistry: Part 2
Cha pter23Oxidative Phosphorylation and Mitochondrial DiseasesSYNOPSISMillie Iroiidni ate I’-i'.v.ilK sliippeil-duwri iinirn-trequlkt: haele-IÍ.1 That Ebook Netter’s essential biochemistry: Part 2t spccnlzc ii energy production. Human iniochondria CI'IISFI of an mierual conipnrtmcni (lhe* miochundml matrix) that cinilanix the Ln/VKILS of lire Clitic acid v.vvV, listlv acxl |>-oxjdatbn. ketone body metabolism. and parts of several bb-syndieltc p.ilhw;iys. Ihe ninlrk k enclosed hy lire inner m Ebook Netter’s essential biochemistry: Part 2ilo-ehondiial membrane, which co mails the proteins for oxilathv phosphoryl: I»r. the inner miochondruil membrane H surrounded by an Ollier niiiichiirEbook Netter’s essential biochemistry: Part 2
ihi.il incnilir.iric that k pcnncalik to amah molecules, lhe region between the two membranes B ihe IIlenne-nhr.tre spacen Oxilath.c plrospliiuvL-.ti.Cha pter23Oxidative Phosphorylation and Mitochondrial DiseasesSYNOPSISMillie Iroiidni ate I’-i'.v.ilK sliippeil-duwri iinirn-trequlkt: haele-IÍ.1 That Ebook Netter’s essential biochemistry: Part 2t- pts: due I-I >11 ofadcnosinc triphosphate (ATP: lig. 23.1L As NADH is oxklizcd. protons <11 Jure pumped 0111 n| lire niuirci mln the miernrem-bianu space J' pail !>fa series id OAÌdaũiii-ivduclkiii ivactMlis. An A1P synthase slows protons to flow back into the uiKoehon-dnilnnnris. mid il uses lir Ebook Netter’s essential biochemistry: Part 2e eirergv linn k freed ni ihk process to phosphorylate adenine địphosphatc (ADP)to ATP. Milochondna con > n lhetrowu DNA Muocbontlm lire Iihroed froniEbook Netter’s essential biochemistry: Part 2
only lliv niollicr. Snirre ofdre prolcnis needed lin osklatkc phosphoryhtbn arc encoded by the DNAn the nữoebondna. bill mosl lire derived fmri the lCha pter23Oxidative Phosphorylation and Mitochondrial DiseasesSYNOPSISMillie Iroiidni ate I’-i'.v.ilK sliippeil-duwri iinirn-trequlkt: haele-IÍ.1 That Ebook Netter’s essential biochemistry: Part 2 require J hụi I Hile of ATI’ pioilui.li.in, such as lire cutilial nervous system, the heart, and skeletal muscle. Pancreatic |i-celk are II km oiler Iiiecleil Slice AH’ synlhesiv k required liir ukicose suti-.riii and iisulii sccivliui.LEARNING OBJECTIVESFor mastery of (his topic, you should be abl Ebook Netter’s essential biochemistry: Part 2e to do thefollowing: a Ik-sciihe lire fiuiclion. cellibr Irenlimi. mid iksiiu dkiriiutiiu of the electron transport chain and ATP synthase.- SuroniiiEbook Netter’s essential biochemistry: Part 2
nw! how components of lhe electron transport chain undergo ■■xidaliiHi-rcducliori rcaclbii' mid Imw the energy liinn such rcactbns É used to pvmp protCha pter23Oxidative Phosphorylation and Mitochondrial DiseasesSYNOPSISMillie Iroiidni ate I’-i'.v.ilK sliippeil-duwri iinirn-trequlkt: haele-IÍ.1 That Ebook Netter’s essential biochemistry: Part 2and pliosphuciu-atinc 11 iitracclnhi- energy transport, and 1st tissues it which lhese mofecules lire especiilk- .• bundanlDifferentiate lire nomial regulation and interplay of ATP synthase aettviy, flux 11 the electron transport chain, flux 11 the ettne next cyvk. and fins -Il gkxmKsk■Assess the ii Ebook Netter’s essential biochemistry: Part 2lhtcnec of a lining concentration of oxygen on oxsialne phosphoryl, I ionTx--re I flic die oiled* of uticnupk:* and ckcliun lian*puil chain inhbitorsEbook Netter’s essential biochemistry: Part 2
on II’.IX through the electron transport ehait and on theiare of uxidalkv phusplioryhlioii; predict die clfccL'. of these agents OU ’lux in cỊẹcoỊysisCha pter23Oxidative Phosphorylation and Mitochondrial DiseasesSYNOPSISMillie Iroiidni ate I’-i'.v.ilK sliippeil-duwri iinirn-trequlkt: haele-IÍ.1 That Ebook Netter’s essential biochemistry: Part 2e [ihuspliorylalion nnd TI protecting lịnd nilegiilv■klentẠa pattern of ir.ioehondiial nheiitancc.■Expiun why some mUochondryllicenses are nhersed wuh an X-lhikcd or autosntii.il recessive pallciu, whiL* ullrers slum maternal inheritance.■I'.xpnTi helemplismy mid xtrow huw 1 rel'.ie* lo varinlmns ri Ebook Netter’s essential biochemistry: Part 2 onset, phenotype, and severityufmr.ochoridin'.diseascscaused by munitions IT. miiochondmlDNA1OXĨDATB E PIIOSPIĨORYI ATIONOxidmivc pliosphorykilkm winEbook Netter’s essential biochemistry: Part 2
sisls <1/au ọxvgcn-reqiiirinụ electron transport chain and an ATT’ sjuthasc. T c electron transport drain uses the reducing power I electrons and pinlCha pter23Oxidative Phosphorylation and Mitochondrial DiseasesSYNOPSISMillie Iroiidni ate I’-i'.v.ilK sliippeil-duwri iinirn-trequlkt: haele-IÍ.1 That Ebook Netter’s essential biochemistry: Part 2e mitochondrial iutcr-ineinbrane space. T e .ATP synthase allows [I 10 /low back inin lire matrix while using the elcclroclimnical H' gr.idieiii to synthesize A7 P from ADPand phosphate. Inhibitors o/thc electron transport chain and Iincouplcrs 0/ oxidative phos-phoiylation both reduce ATP prodiicii Ebook Netter’s essential biochemistry: Part 2on by oxidative phosphor yla linn.1.1.Structure and Function of MitochondriaMitochondria arc present in niosi cells. Maiurcred blood cells do not haveEbook Netter’s essential biochemistry: Part 2
mitochondria. Fast white muscle cells have very lew miiochondria. In contrast, organs Such as the brain and he.'in contain many niitiichmiilri.i.MitoCha pter23Oxidative Phosphorylation and Mitochondrial DiseasesSYNOPSISMillie Iroiidni ate I’-i'.v.ilK sliippeil-duwri iinirn-trequlkt: haele-IÍ.1 That Ebook Netter’s essential biochemistry: Part 2 the shape of an elongated beau, they actually form a highly dynamic tubular reticulum inside of cells.T e matrix space contains the enzymes of lire cilric acid cycle (sw Chapter 22); fully acid p-oxidation, ketone body synthesis, and ketone body oxidation I sec Chapter 27): pans of heme synthesis ( Ebook Netter’s essential biochemistry: Part 2see Chapter 14). steroid symhesis I see Chapter 31); prolein metabolism (see Chapters 34 and 35); and the urea cycle (sec Chapter Ì5). r c inner mitocEbook Netter’s essential biochemistry: Part 2
hondrial membrane contains the components of oxidative phosphorylation discussed in ihis chapter. T e Ollier membrane is permeable to small molecules.Cha pter23Oxidative Phosphorylation and Mitochondrial DiseasesSYNOPSISMillie Iroiidni ate I’-i'.v.ilK sliippeil-duwri iinirn-trequlkt: haele-IÍ.1 That Ebook Netter’s essential biochemistry: Part 2iauiụutlLaitaat AirIaivhI.iii of -iitDNA • nJ crii.i id eveL1.2.Electron Transport ( hainCha pter23Oxidative Phosphorylation and Mitochondrial DiseasesSYNOPSISMillie Iroiidni ate I’-i'.v.ilK sliippeil-duwri iinirn-trequlkt: haele-IÍ.1 ThatGọi ngay
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