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Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

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Nội dung chi tiết: Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

Part IIDiagnostic ChallengesSpitz Nevus Versus Spitzoid Melanoma6Victor G. Prieto, Christopher R. Shea, and Jon A. ReedSpitz nevus is a biologically b

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2benign nevus associated with a good prognosis, but sometimes it can cause diagnostic concern since it can be difficult to distinguish from atypical me

lanocytic lesions and melanoma on histological grounds. Originally designated as "juvenile melanoma", it presents as a solitary rapidly growing, red o Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

r flesh-colored papule arising on the face, trunk, or extremities of children and adolescents. Most Spitz nevi are compounds although they can be junc

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

tional or intradermal. The lesions tend to show lateral circumscription and are symmetric. The junctional nests, when present, are cohesive and vertic

Part IIDiagnostic ChallengesSpitz Nevus Versus Spitzoid Melanoma6Victor G. Prieto, Christopher R. Shea, and Jon A. ReedSpitz nevus is a biologically b

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2ated, sometimes showing pseu-doepitheliomatous hyperplasia. Cells are epithelioid or spindled. There may be pagetoid upward migration but this is circ

umscribed to the centerV.G. Prieto. M.D.. Ph D. (K)MD Anderson Cancer Center. University of Houston.1515 Holcombe Blvd.. Unit 85. Houston.TX 77030, US Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

Ae-mail: vprietotp mdanderson.orgC.R. SheaUniversity of Chicago Medicine.5841 s. Maryland Ave.. MC 5067. L5O2.Chicago. IL 60637, USAJ.A. ReedCellNEti.

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

x Pathology & Laboratories.1124 Columbia St.. Suite 200. Seattle.WA 98117. USAof the lesion and not at the periphery. Adjacent IO melanocytes there ar

Part IIDiagnostic ChallengesSpitz Nevus Versus Spitzoid Melanoma6Victor G. Prieto, Christopher R. Shea, and Jon A. ReedSpitz nevus is a biologically b

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2 in fascicles and have a large ample eosinophilic cytoplasm with eosinophilic nucleoli. Some of the epithelioid cells can show bizarre shapes but the

degree of cytologic atypia is mostly uniform throughout the entire lesion. Commonly there is maturation with descent in the dermis and cells infiltrat Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

e among collagen bundles. The upper dermis may show edema and superficial telangiectases. There are features that appear to be different in Spitz nevi

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

depending on the patient's age. There may be mitotic figures in the superficial dermal portion of the nevus, especially in younger patients. Pagetoid

Part IIDiagnostic ChallengesSpitz Nevus Versus Spitzoid Melanoma6Victor G. Prieto, Christopher R. Shea, and Jon A. ReedSpitz nevus is a biologically b

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2ents than in adults. In adults, isolated cells w ithin the lateral edges of the lesion are more common in Spitz nevus than in spitzoid melanoma 13].Pi

gmented spindle cell nevus of Reed is considered by most authors to be a pigmented variant of Spitz nevus, more common in young women, in the extremit Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

ies (particularly on the thigh). The desmoplastic variant presents as a brown papule on the extremities of young adults. It is wedge-shaped. with pleo

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

morphic spindle and epithelioid cells with abundant eosinophilic cytoplasm arranged among thick collagen libers |4|.C.R Shea Cl al. (eds.). Pathology

Part IIDiagnostic ChallengesSpitz Nevus Versus Spitzoid Melanoma6Victor G. Prieto, Christopher R. Shea, and Jon A. ReedSpitz nevus is a biologically b

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2.G. Prieto et al.Fig. 6.1 Compound Spitz nevus: (a and b> note the regular elongation of retc ridges and the wedge-shape of the lesion in the dermis.

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

us epithelioid and spindle cell lesions. Epithelioid fibrous histiocytoma [5] presents as a raised, nonpigmented or light brown papule on the extremit

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

ies of adults. Histologically it is a dermal lesion, composed of clusters of epithelioid. bland-looking cells, with abundant eosinophilic cytoplasm an

Part IIDiagnostic ChallengesSpitz Nevus Versus Spitzoid Melanoma6Victor G. Prieto, Christopher R. Shea, and Jon A. ReedSpitz nevus is a biologically b

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2elanoma. In contrast with either one. epithelioid fibrous histiocytoma does not express melanocytic markers such as MARTI, gpioo. or MiTF. The lesiona

l cells are typically positive for FXIIIa. CD68. and CDI63. Anti-SlOO may be a pitfall since it labels dendritic cells and thus it may be incorrectly Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

interpreted as positive in the lesional cells.Junctional Spitz nevi may resemble dysplastic nevi; furthermore, some authors have suggested the term "S

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

park” nevus for lesions that have features common to "Clark" (dysplastic) and "Spitz" nevi |6j. In general, dysplastic nevi occur in patients al any a

Part IIDiagnostic ChallengesSpitz Nevus Versus Spitzoid Melanoma6Victor G. Prieto, Christopher R. Shea, and Jon A. ReedSpitz nevus is a biologically b

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2liferation, and a lymphocytic infiltrate containing melanophages |7|. In general, for such cases with mixed features between spitz and dysplastic. the

differential diagnosis may not be so important, since in both cases a complete excision is probably the recommended management (see also Chap. 9).spi Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

lzoid melanoma is the preferred term for those malignant melanocytic lesions showing large, epithelioid melanocytes with prominent6 Spitz Nevus Versus

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

Spitzoid Melanoma51Fig. 6.2 Compound Spitz nevus: (at HMB45 shows decreased expression with depth, (bl A double immunostudy shows very low proliferat

Part IIDiagnostic ChallengesSpitz Nevus Versus Spitzoid Melanoma6Victor G. Prieto, Christopher R. Shea, and Jon A. ReedSpitz nevus is a biologically b

Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2hose lesions have at least some of the features of standard melanomas: irregular junctional component (variably sized nests), dermal mitotic figures (

located in the lower half of the lesion), possibly of atypical shapes, pagetoid upward migration prominent or else at the periphery of the lesion, exp Ebook Pathology of challenging melanocytic neoplasms - Diagnosis and management: Part 2

ansile pattern of growth in the dermis, pushing border in the deep dermis.

Part IIDiagnostic ChallengesSpitz Nevus Versus Spitzoid Melanoma6Victor G. Prieto, Christopher R. Shea, and Jon A. ReedSpitz nevus is a biologically b

Part IIDiagnostic ChallengesSpitz Nevus Versus Spitzoid Melanoma6Victor G. Prieto, Christopher R. Shea, and Jon A. ReedSpitz nevus is a biologically b

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