Ebook Pulmonary drug delivery: Part 2
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Ebook Pulmonary drug delivery: Part 2
8Particle Engineering for Improved Pulmonary Drug Delivery Through Dry Powder InhalersWaseem Kaicdy'-* and Ali Nokhodchf;■*'School of Pharmacy, Eacult Ebook Pulmonary drug delivery: Part 2ty of Science and Engineering, University of Wolverhampton. UK -School of Life Sc iences, Universily of Sussex, UKiDrug Applied Research Center and Eacnlty of Pharmacy. Tabriz University of Medical Sciences.IranAbbreviationsList of Abbreviations« Auk- or API A I 'M CI CCM € l)b D, or D_. If DPI EM E Ebook Pulmonary drug delivery: Part 2D ERAngle of repose True density Active pharmaceutical ingredient Atomic force microscope Carr’s index Cooling crystallised mannitol Median diameter AEbook Pulmonary drug delivery: Part 2
erodynamic diameter Bulk density Geometric diameter ■fap densify Dry powder inhaler Emission Emitted dose Elongation ratio* w.kaialy@wlv.ac.uka.nokhod8Particle Engineering for Improved Pulmonary Drug Delivery Through Dry Powder InhalersWaseem Kaicdy'-* and Ali Nokhodchf;■*'School of Pharmacy, Eacult Ebook Pulmonary drug delivery: Part 2 Ltd. Published 2015 by John Wiley & Sons. Ltd.172Pulmonary Drug DeliveryFPDFine particle doseFPFFine particle fractionGASGas antisolventGSDGeometric standard deviationHR1 lausner ratioIGCInverse gas chromatographyILImpaction lossI.PPsLarge porous particlesMMADMass median aerodynamic diameterPGSSPre Ebook Pulmonary drug delivery: Part 2cipitation from gas saturated solutionspMDlPressurised metered dose inhalersPSDParticle size distributionPSGPressure swing granulationRDRecovered doseEbook Pulmonary drug delivery: Part 2
Ri:ssRapid expansion of supercritical fluid solutionSCI-Supercritical fluidSI JISSolution enhanced dispersion by SCI8.1IntroductionOral drug delivery'8Particle Engineering for Improved Pulmonary Drug Delivery Through Dry Powder InhalersWaseem Kaicdy'-* and Ali Nokhodchf;■*'School of Pharmacy, Eacult Ebook Pulmonary drug delivery: Part 2ility. Nevertheless this route of drug delivery does have a number of associated disadvantages such as possible unpredictable absorption rales [1]. the potential for drug degradation by the digestive acid and enzymes, as well as drug inactivation in the liver and the lack of organ sclccliv ily (comp Ebook Pulmonary drug delivery: Part 2ared to that achievable by other routes including the pulmonary ). Drug delivery by inhalation has been employed routinely for the treatment of localiEbook Pulmonary drug delivery: Part 2
zed diseases such as asthma and other pulmonary conditions. Delivery via the airways has also been used in the treatment or management of systemic dis8Particle Engineering for Improved Pulmonary Drug Delivery Through Dry Powder InhalersWaseem Kaicdy'-* and Ali Nokhodchf;■*'School of Pharmacy, Eacult Ebook Pulmonary drug delivery: Part 2 use by inhalation delivery |4|. It is apparent, therefore, that this route of drug delivery is important. but performance of inhalation products is still generally poor. Illis is one of the main reasons for interest in the modification of drug or carrier particles by particle engineering, so as to Ebook Pulmonary drug delivery: Part 2enhance the performance of formulations in vivo. and as assessed in vitro.8.2Dry Powder InhalersDry powder inhalers (DPIs) comprise a pharmaceutical dEbook Pulmonary drug delivery: Part 2
osage form of increasing popularity with attractive features such as the provision of a propellant-free means of drug delivery and such formulations h8Particle Engineering for Improved Pulmonary Drug Delivery Through Dry Powder InhalersWaseem Kaicdy'-* and Ali Nokhodchf;■*'School of Pharmacy, Eacult Ebook Pulmonary drug delivery: Part 2 specific inhaler devices are available elsewhere (see Chapter 3).8.3Particle Engineering to Improve the Performance of DPIsIn attempts to enhance the efficiency of delivery from DPIs. several techniques have been utilised to prepare particles of active pharmaceutical ingredients (APIs) and carriers Ebook Pulmonary drug delivery: Part 2 (e.g.. lactose or mannitol).8Particle Engineering for Improved Pulmonary Drug Delivery Through Dry Powder InhalersWaseem Kaicdy'-* and Ali Nokhodchf;■*'School of Pharmacy, Eacult8Particle Engineering for Improved Pulmonary Drug Delivery Through Dry Powder InhalersWaseem Kaicdy'-* and Ali Nokhodchf;■*'School of Pharmacy, EacultGọi ngay
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