Ebook The cell language theory - Connecting mind and matter: Part 2
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Ebook The cell language theory - Connecting mind and matter: Part 2
Chapter 7Applications of the Cell Language Theory to Biomedical SciencesMost, if not all, human diseases, both somatic and mental, can be said to aris Ebook The cell language theory - Connecting mind and matter: Part 2se from miscommunication and disregulation of metabolism within individual cells (i.e., intracellular semiosis) or between cells (i.e., intercellular semiosis) in the human body. Hence, the cell language theory and medical sciences are intimately related.The cell language theory is one of the four m Ebook The cell language theory - Connecting mind and matter: Part 2ajor theoretical building blocks underlying the theoretical mode! of the living cell known as the Bhopalator discussed in Chapter 3. The four componenEbook The cell language theory - Connecting mind and matter: Part 2
ts of the Bhopalator, i.e., cell language, cell force, intracellular dissipative structures (IDSs), and conformons, are depicted in Figure 7.1 as the Chapter 7Applications of the Cell Language Theory to Biomedical SciencesMost, if not all, human diseases, both somatic and mental, can be said to aris Ebook The cell language theory - Connecting mind and matter: Part 2s are all equivalent and in simultaneous contact with one another, which is used in Figure 7.1 as a topological means to symbolize the essentiality and the interconnectedness of the four theoretical components of the living cell. In other words, these four theoretical building blocks constitute the Ebook The cell language theory - Connecting mind and matter: Part 2irreducible tetrad of the cell (ITC). The principle of ITC implies that the cell structure and function cannot be completely accounted for without impEbook The cell language theory - Connecting mind and matter: Part 2
licating all of the four theoretical components, although, at any given time, only one or two of them may be prescinded (i.e., selected out or highligChapter 7Applications of the Cell Language Theory to Biomedical SciencesMost, if not all, human diseases, both somatic and mental, can be said to aris Ebook The cell language theory - Connecting mind and matter: Part 2odel of the living cell, the Bhopalator. The geometric figure employed here is called the BCT (Body-Centered Tetrahedron) (see Figure 10.15) that has been found to provide a useful template for modeling many processes and structures in the Universe (see Section 10.17).emphasis, temporarily ignoring Ebook The cell language theory - Connecting mind and matter: Part 2the rest of the components, for the convenience of thought). As we attempt to apply the cell language theory’ in this chapter to solve practical problEbook The cell language theory - Connecting mind and matter: Part 2
ems in biomedical sciences, our emphasis will be placed on the intercellular or intracellular communications (or semiosis) mediated by the cell languaChapter 7Applications of the Cell Language Theory to Biomedical SciencesMost, if not all, human diseases, both somatic and mental, can be said to aris Ebook The cell language theory - Connecting mind and matter: Part 2dical SciencesH. H. Heng, the author of Debating Cancer [297], recently stated that:The explosion of genomic information has generated both excitement and confusion. The paradox of knowing more about cancer's genetic landscape yet understanding less of its common molecular basis represents such an e Ebook The cell language theory - Connecting mind and matter: Part 2xample. It was believed or hoped by many that the cancer genome sequencing project would once and for all solve the mystery of cancer, without anticipEbook The cell language theory - Connecting mind and matter: Part 2
ating that the powerful technologyApplications of the Cell Language Theory to Biomedical Sciences 291would further add to the unmanageable complexity Chapter 7Applications of the Cell Language Theory to Biomedical SciencesMost, if not all, human diseases, both somatic and mental, can be said to aris Ebook The cell language theory - Connecting mind and matter: Part 2derstanding of cancer is actually fading away.... What is the real problem? Not enough molecular data yet? No suitable model for data analyses? Or on an even more serious note, has there been a wrong conceptual framework all along?-7.1Of the three possible explanations for the “cancer paradox” that Ebook The cell language theory - Connecting mind and matter: Part 2Heng is conceptualizing, I think that the last possibility is the most likely explanation, i.e., a wrong conceptual framework for not only cancer reseEbook The cell language theory - Connecting mind and matter: Part 2
arch, but also for the biomedical science research and education, in general.7.1.1The Inefficiency of the Current Methods of Drug DevelopmentOne evideChapter 7Applications of the Cell Language Theory to Biomedical SciencesMost, if not all, human diseases, both somatic and mental, can be said to aris Ebook The cell language theory - Connecting mind and matter: Part 2ment research. According to Bain & Company [298], the cost of developing a new drug is estimated to be SI.7 billion and it takes 12-16 years to complete a drug development process from the compound discovery stage to marketing. The overall attrition rate for developing a drug is calculated to be 10, Ebook The cell language theory - Connecting mind and matter: Part 2000:1. According to another survey, the United States invested a total of S25 billion in 2000 on the research and development for pharmaceuticals andEbook The cell language theory - Connecting mind and matter: Part 2
produced only 11 new drugs on the market in that year, costing the US pharmaceutical industry S2.3 billion per new drug. In addition, once a drug is aChapter 7Applications of the Cell Language Theory to Biomedical SciencesMost, if not all, human diseases, both somatic and mental, can be said to aris Ebook The cell language theory - Connecting mind and matter: Part 2Precision MedicineIn his State of the Union Address on January’ 30, 2015, President Obama launched the Precision Medicine Initiative with the following statement:Doctors have always recognized that every patient is unique, and doctors have always tried to tailor their treatments as best they can to Ebook The cell language theory - Connecting mind and matter: Part 2individuals. You can match a blood transfusion to a blood type — that was an important discovery. What if matching a cancer cure to our292 The Cell LaEbook The cell language theory - Connecting mind and matter: Part 2
nguage Theory: Connecting Mind and Mattergenetic code was just as easy, just as standard? What if figuring out the right dose of medicine was as simplChapter 7Applications of the Cell Language Theory to Biomedical SciencesMost, if not all, human diseases, both somatic and mental, can be said to aris Ebook The cell language theory - Connecting mind and matter: Part 2enting the Mission Statement (Figure 7.2(b)) of the Precision Medicine Initiative, as briefly summarized in Figure 7.2(c) and 7.2(d) and in the figure legend.President Obama. Retrieved from https: www.whitehouse.gov.'precision-medicine on 01 04/2016.(b)The Mission Statement:"To enable a new era of m Ebook The cell language theory - Connecting mind and matter: Part 2edicine through research, technology, and policies that empower patients, researchers, and providers to work together toward development of individualEbook The cell language theory - Connecting mind and matter: Part 2
ized treatments. "(c)Efficient Drug DevelopmentPersonalized Medicine(d)Precision Medicine = PDE + Microarray Technology + the Bhopalator PiscatawaytorChapter 7Applications of the Cell Language Theory to Biomedical SciencesMost, if not all, human diseases, both somatic and mental, can be said to aris Ebook The cell language theory - Connecting mind and matter: Part 2 Bhopalator model of the cell), (ii) the microarray technology. and (iii) PDE (as a quantitative method for classifying the normal and disease states of the human body (see Section 7.3 for specific examples), the theoretical model of which being the Piscatawaytor (formulated in 1991).Applications of Ebook The cell language theory - Connecting mind and matter: Part 2 the Cell Language Theory to Biomedical Sciences 293The proposed strategy of implementing the Precision Medicine Initiative (PMĨ) is based on three coEbook The cell language theory - Connecting mind and matter: Part 2
mponents: (i) the cell language-based model of the living cell, the Bhopalator, and the human body, the Piscalawaylor (see Section 3.2.20), (ii) (he mChapter 7Applications of the Cell Language Theory to Biomedical SciencesMost, if not all, human diseases, both somatic and mental, can be said to aris Ebook The cell language theory - Connecting mind and matter: Part 2n Chapter 8) that introduces a new quantitative method for classifying long-tailed histograms of mRNA levels measured from both normal and diseased cells and tissues. Since the microarray technique plays a fundamental role not only in the proposed strategy for implementing PMĨ, but also in possibly Ebook The cell language theory - Connecting mind and matter: Part 2ushering in a paradigm shift in cell biology and medicine, this method and its implications in biology are discussed in some detail in the following sEbook The cell language theory - Connecting mind and matter: Part 2
ections.Chapter 7Applications of the Cell Language Theory to Biomedical SciencesMost, if not all, human diseases, both somatic and mental, can be said to arisChapter 7Applications of the Cell Language Theory to Biomedical SciencesMost, if not all, human diseases, both somatic and mental, can be said to arisGọi ngay
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