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Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2

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Nội dung chi tiết: Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2

Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2

ctwẹ*ío» UfidfttosCentral Hypothyroidism12Andrea Lania, Claudia Giavoli, and Paolo Beck-PeccozContentsEpidemiology....................................

Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2..................................... 374Etiopathogenesis.................................................................... 374Congenital CH........

............................................................ 376Acquired......................................................................... 378C Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2

linical and Biochemical Presentation............................................... 380Treatment and Eollow-Up........................................

Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2

..................... 382Summary............................................................................. 384Cross-References.....................

ctwẹ*ío» UfidfttosCentral Hypothyroidism12Andrea Lania, Claudia Giavoli, and Paolo Beck-PeccozContentsEpidemiology....................................

Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2tral hypothyroidism (CH) is a clinical condition characterized by a defect in thyroid hormone secretion due to an insufficient stimulation by thyrotro

pin (TSH) of an otherwise normal thyroid gland. CH is a rare and heterogeneous disorder that is caused by abnormalities of cither the pituitary gland Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2

or the hypothalamus, and it may be congenital or acquired. The clinical manifestations are usually milder than those observed in primary hypothyroidis

Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2

m, and the CH diagnosis isA. Lania (E3)Department of Medical Sciences, Humanitas University and Endocrinology Unit. HumanitasResearch Hospital. Rozzan

ctwẹ*ío» UfidfttosCentral Hypothyroidism12Andrea Lania, Claudia Giavoli, and Paolo Beck-PeccozContentsEpidemiology....................................

Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2lye-mail: giavoli@yahoo.itp. Beck-PeccozUniversity of Milan. Milano. Italye-mail: paolo.beckpeccoz@unimi.itIỈ Springer International Publishing AG, pa

rt of Springer Nature 2018 p. Villi, L. I legediis (eds.). Thyroid Diseases, Endocrinology.hltDsi.7doi.ore/10.1007/978-3-319-45013-1 13373374A. Lania Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2

et al.based on low circulating levels of free thyroid hormone and low/nonnal TSH. CH treatment is based on L-thyroxinc (L-T4) supplementation, the ade

Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2

quacy of which is evaluated by measuring circulating free thyroxine (FT4). This chapter analyzes our current understanding of the causes of CH and hig

ctwẹ*ío» UfidfttosCentral Hypothyroidism12Andrea Lania, Claudia Giavoli, and Paolo Beck-PeccozContentsEpidemiology....................................

Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2ism (CH) is a clinical condition characterized by a defect in thyroid hormone secretion due to an insufficient stimulation by thyrotropin (TSH) of an

otherwise normal thyroid gland. CH is a rare and heterogeneous disease caused by abnormalities of either the pituitary gland (Ĩ.C.. secondary hypothyr Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2

oidism) or the hypothalamus (i.c., tertiary hypothyroidism).The prevalence of CH ranges from 1:20,000 to 1:80,000 individuals in the general populatio

Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2

n (Price and Wcctman 2001) and represents an uncommon cause of hypothyroidism (one of 1.000 hypothyroid patients). As far as congenital CH is concerne

ctwẹ*ío» UfidfttosCentral Hypothyroidism12Andrea Lania, Claudia Giavoli, and Paolo Beck-PeccozContentsEpidemiology....................................

Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2usually associated with inappropriately nonnal/low TSH in the presence of low circulating FT4 levels. When screening programs for neonatal Cl 1 includ

e both TS11 and FT4 measurements, its prevalence increases to 1:160.000 (Asakura Ct al. 2002; Nebesio Ct al. 2010). Interestingly, CH prevalence furth Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2

er increases to 1 in 16,000 newboms if the screening algorithm is based on the combined measurement of TSH, T4. and thyroxine-binding globulin, which

Ebook Thyroid diseases - Pathogen esis, diagnosis, and treatment: Part 2

could be effective in diagnosing the milder forms of the disease (Kempers Ct al. 2006).

ctwẹ*ío» UfidfttosCentral Hypothyroidism12Andrea Lania, Claudia Giavoli, and Paolo Beck-PeccozContentsEpidemiology....................................

ctwẹ*ío» UfidfttosCentral Hypothyroidism12Andrea Lania, Claudia Giavoli, and Paolo Beck-PeccozContentsEpidemiology....................................

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