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Sports nutrition fats and proteins part 2

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Sports nutrition fats and proteins part 2

'l Q Glucosamine and Chondroitin SulfateCatherine C.R. JacksonCONTENTS10.1Introduction......................................................18710.2Des

Sports nutrition fats and proteins part 2 scription of Products...........................................18810.2.1Glucosamine...............................................18810.2.2Chondroili

n Sulfate.......................................18910.3Mechanisms........................................................18910.3.1Glucosamine......... Sports nutrition fats and proteins part 2

......................................18910.3.2Chondroitin Sulfate.......................................19010.4Review of Research Studiesand Clinical

Sports nutrition fats and proteins part 2

Trials....................19010.4.1Glucosamine...............................................19010.4.2Chondroilin Sulfate............................

'l Q Glucosamine and Chondroitin SulfateCatherine C.R. JacksonCONTENTS10.1Introduction......................................................18710.2Des

Sports nutrition fats and proteins part 2 19410.5.1(Ỉ lucosamine.............................................19410.5.2Chondroilin Sulfate.......................................19410.6Use in Sp

ort and Exercise.........................................19410.7Summary and Recommendations.......................................195References....... Sports nutrition fats and proteins part 2

......................................................19610.1 INTRODUCTIONAmericans currently spend more money on natural remedies for osteoarthritis

Sports nutrition fats and proteins part 2

than for any other medical condition,1 thus producing an extremely large and lucrative market for the mulli-billion-dollar supplement industry. Osteoa

'l Q Glucosamine and Chondroitin SulfateCatherine C.R. JacksonCONTENTS10.1Introduction......................................................18710.2Des

Sports nutrition fats and proteins part 2 the U.S. suffer from osteoarthritis: it is predicted that this number will double over the next 20 years. Increasing age, female gender, and obesity a

re risk factors. It is also known that athletes of all types frequently live with chronic joint pain often associated with overuse injuries; they pres Sports nutrition fats and proteins part 2

ent an additional mulli-million-dollar market for the supplements. Glucosamine and chondroitin sulfate have been widely publicized in the popular medi

Sports nutrition fats and proteins part 2

a as being capable of decelerating the degenerative processes, decreasing pain, and maintaining and improving joint function188Sports Nutrition: Fats

'l Q Glucosamine and Chondroitin SulfateCatherine C.R. JacksonCONTENTS10.1Introduction......................................................18710.2Des

Sports nutrition fats and proteins part 2 ere are numerous anecdotal reports to which supplement manufacturers refer. However, the majority of clinical trials have small sample sizes, little o

r no follow-up. and are sponsored by the supplement manufacturers.2 Problems ill evaluation of efficacy begin with classification of these agents, as Sports nutrition fats and proteins part 2

they have been called drugs, nulriceulicals, food supplements, alternative therapy, homeopathic therapy, and complementary therapy. lndi\ iduals with

Sports nutrition fats and proteins part 2

joint pain now consume very large quantities of glucosamine and chondroitin primarily based on a great volume of media coverage as to then- value. The

'l Q Glucosamine and Chondroitin SulfateCatherine C.R. JacksonCONTENTS10.1Introduction......................................................18710.2Des

Sports nutrition fats and proteins part 2 ults in poor-quality cartilage. Bones may become exposed and rub together, which creates damage and pain. With lime, bones chip and fracture, which ca

n lead to bone growth, producing increased pain and lack of mobility. The individual finds that this disrupts daily life and activity makes symptoms w Sports nutrition fats and proteins part 2

orse. Patients feel unwell and depressed. Active individuals may terminate exercise completely, which increases the risks of inactivity-related chroni

Sports nutrition fats and proteins part 2

c diseases.Osteoarthritis affects approximately 12% of the U.S. population and is a common cause of age-related pain and physical disability. The cond

'l Q Glucosamine and Chondroitin SulfateCatherine C.R. JacksonCONTENTS10.1Introduction......................................................18710.2Des

Sports nutrition fats and proteins part 2 inophen, and nonsteroidal anti-inflammatory drugs (NSAIDs). Interestingly, the origin of pain caused by the condition is unclear and. upon investigati

on, is more often attributed to lesions or referred pain rather than articular problems, as there arc no nerves in articular cartilage. The biochemist Sports nutrition fats and proteins part 2

ry of glucosamine has led to the suggestion that its use might stop and possibly reverse the degenerative process. However, evidence is questionable.

Sports nutrition fats and proteins part 2

C hard and Dieppe3 showed great insight into the problem by commenting that glucosamine may become the first agent about which we have more published

'l Q Glucosamine and Chondroitin SulfateCatherine C.R. JacksonCONTENTS10.1Introduction......................................................18710.2Des

Sports nutrition fats and proteins part 2 ound 9 reviews and numerous comments and editorials. Most primary research studies arc poor, and positive results are invariably found in supplement m

anufacturer-sponsored research, (’hard and Dieppe3 also concluded that there is more hype than magic, rationales for use are unclear, best dose and ro Sports nutrition fats and proteins part 2

ute of administration arc unknown, and published work does not allow conclusions about efficacy or effectiveness. However, since it is safe, toxicity

Sports nutrition fats and proteins part 2

concerns cannot be raised. There is a need for regulation, as there could be long-term side effects, while the length of treatment is not known. Other

'l Q Glucosamine and Chondroitin SulfateCatherine C.R. JacksonCONTENTS10.1Introduction......................................................18710.2Des

Sports nutrition fats and proteins part 2 racture in breast implants.510.2DESCRIPTION OF PRODUCTS10.2.1 GlucosamineGlucosamine is an amino monosaccharide (amine sugar) that can be found in chi

tin. clvrnnmTpinc and the (dvrncaminndvranc íninronnlvỉar-rharidpcì enrh henarinGlucosamine and Chondroitin Sulfate189sulfate and hyaluronic acid. Oth Sports nutrition fats and proteins part 2

er chemical designations are 2-amino-2-deoxy-bcta-D-glucopyranose, 2-amino-2-deoxyglucose. and chitosamine.6 It is available over the counter as a nut

Sports nutrition fats and proteins part 2

ritional supplement as glucosamine hydrochloride (glucosamine HC1). glucosamine sulfate, or N-acetyl-glucosamine. Research has used primarily the chlo

'l Q Glucosamine and Chondroitin SulfateCatherine C.R. JacksonCONTENTS10.1Introduction......................................................18710.2Des

Sports nutrition fats and proteins part 2 olecule has a positive charge. Negative anions arc found in the salt forms, which neutralize the charge. In glucosamine sulfate the anion is sulfate,

in glucosamine HCl the anion is chloride, and in N-acetylglucosamine the amino group is acetylated, which results in a neutral charge. All forms are w Sports nutrition fats and proteins part 2

aler soluble. Nutritional supplements are usually derived from marine exoskelelons with the chitin extracted from seashells. There arc also synthetic

Sports nutrition fats and proteins part 2

forms. Since glucosamine falls under the 1994 Dietary Supplement Health and Education Act (DSHEA) and is classified as a medicinal product, its manufa

'l Q Glucosamine and Chondroitin SulfateCatherine C.R. JacksonCONTENTS10.1Introduction......................................................18710.2Des

Sports nutrition fats and proteins part 2 er cannot know what is contained in the product as glucosamine is inherently unstable and must be combined with other ingredients for stability. Analy

sis of products consistently produces the result that many formulations do not contain ingredients listed on the label.'10.2.2Chondroitin SulfateChond Sports nutrition fats and proteins part 2

roitin sulfate is a hetcropolysaccharidc identified as a glycosaminoglycan (GAG). GAGs form the ground substance in connective tissue's extracellular

Sports nutrition fats and proteins part 2

matrix, rhe molecule itself is comprised of repealing linear units of D-galactosamine and □-glucuronic acid. Il is found in human cartilage, cornea, b

'l Q Glucosamine and Chondroitin SulfateCatherine C.R. JacksonCONTENTS10.1Introduction......................................................18710.2Des

Sports nutrition fats and proteins part 2 itin sulfate c (chondroitin 6-sulfate). The two forms differ in the amino group of chondroitin sulfate A and in the sulfate group of chondroitin sulfa

te c. There is a B form called dermatan sulfate, which is found in heart valves, tendons, skin, and arterial walls. The molecular weights of all forms Sports nutrition fats and proteins part 2

range from 5,000 to 50.000 daltons. It is available over the counter as a nutritional supplement, usually in an isomeric mixture of A and c forms. Nu

Sports nutrition fats and proteins part 2

tritional supplements arc derived from varied sources, such as pork by-products (ears, snout), bovine trachea cartilaginous rings, whale septum, and s

'l Q Glucosamine and Chondroitin SulfateCatherine C.R. JacksonCONTENTS10.1Introduction......................................................18710.2Des

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