Trung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: Trung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center
Trung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center
VIETNAM NATIONAL UNIVERSITY, HANOI UNIVERSITY OF ENGINEERING AND TECHNOLOGY....NGUYEN HA ANH TUANA MAXIMUM LIKELIHOOD METHOD FOR DETECTING BAD SAMPLES Trung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center S FROM ILLUMINA BEADCHIPS DATAMASTER THESIS OF INFORMATIONTECHNOLOGYHanoi - 2012VIETNAM NATIONAL UNIVERSITY, HANOI UNIVERSITY OF ENGINEERING AND TECHNOLOGY....NGUYEN HA ANH TUANA MAXIMUM LIKELIHOOD METHOD FOR DETECTING BAD SAMPLES FROM ILLUMINA BEADCHIPS DATAMASTER THESISSector: Information Technolo Trung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center gyMajor:Computer ScienceCode :60 48 01Supervised by: Dr. Le Sy VinhHanoi - 2012ORIGINALITY STATEMENT‘I hereby declare that I llis submission is my ownTrung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center
work and Io the best. of my knowledge it contains no materials previously published or written by another person, or substantial proportions of materVIETNAM NATIONAL UNIVERSITY, HANOI UNIVERSITY OF ENGINEERING AND TECHNOLOGY....NGUYEN HA ANH TUANA MAXIMUM LIKELIHOOD METHOD FOR DETECTING BAD SAMPLES Trung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center owledgement is made in the thesis. I also declare that the intellectual content of this thesis is the product of my own work, except to the extent that assistance from others in the project’s design and conception or in style, presentation and linguistic expression is acknowledged?Signed............ Trung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center ....................1AcknowledgementsFirst and foremost. 1 would like to express my sincere gratitude to my advisor. Dr. Sy Vinh Le, for the continuouTrung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center
s support of my Master study and research, for his patience, motivation, enthusiasm, and immense knowledge. His guidance helped me in all the time of VIETNAM NATIONAL UNIVERSITY, HANOI UNIVERSITY OF ENGINEERING AND TECHNOLOGY....NGUYEN HA ANH TUANA MAXIMUM LIKELIHOOD METHOD FOR DETECTING BAD SAMPLES Trung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center to thank Dr. Si Quang Le. for his encouragement. insightful comments during the time I am working on this project.My sincerely thank goes to University of Engineering and Technology, \ ietnam National University, Hanoi, for offering me a chance to study and complete my Master thesis.Last but not le Trung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center ast. 1 would like to thank my friends who always help and encourage me to finish this thesis as well as in my daily life.iiAbstractGenotype data proviTrung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center
de crucial information to understand effects of genetic variation to human health. Current microarray technologies are able to generate raw genotype dVIETNAM NATIONAL UNIVERSITY, HANOI UNIVERSITY OF ENGINEERING AND TECHNOLOGY....NGUYEN HA ANH TUANA MAXIMUM LIKELIHOOD METHOD FOR DETECTING BAD SAMPLES Trung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center notypes. Genotype calls of different callers might not Im' consistent due to noise of bad samples or SNPs. This requires a manu.d quality control step conducted by experts to remove bad samples or bad SNP sites. In this paper, we propose a maximum likelihood method to detect bad samples to improve t Trung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center he reliability of the results. Experiments with real data demonstrate the usefulness of our method in the quality control process. Thus, our method haTrung tâm Thư viện và Tri thức số - Library and Digital Knowledge Center
s the ability to reduce the number of samples that are requested to manually check by experts.Table of ContentsOverview11Introduction31.1Biological baVIETNAM NATIONAL UNIVERSITY, HANOI UNIVERSITY OF ENGINEERING AND TECHNOLOGY....NGUYEN HA ANH TUANA MAXIMUM LIKELIHOOD METHOD FOR DETECTING BAD SAMPLESVIETNAM NATIONAL UNIVERSITY, HANOI UNIVERSITY OF ENGINEERING AND TECHNOLOGY....NGUYEN HA ANH TUANA MAXIMUM LIKELIHOOD METHOD FOR DETECTING BAD SAMPLESGọi ngay
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