Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies
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Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies
A COMPUTATIONAL FRAMEWORK FOR SIMULATING CARDIOVASCULAR FLOWS IN PATIENT-SPECIFIC ANATOMIESA DISSERTATIONSUBMITTED TO THE FACULTY OF THE GRADUATE SCHO Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies OOL OF THE UNIVERSITY OF MINNESOTABYTiling Bao LeIN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF Doctor of PhilosophyProfessor Fotis SotiropoulosDecember. 2011AcknowledgementsI gratefully acknowledge the instruction of my advisor, Profi’ssor Sotiroponlos, who guided me all the ways thro Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies ugh a scries of challenges during my lime at Saint Anthony Falls Lab. I am in debt of his encouragement, and Iwlief in my capability of put ting out mLuận văn a computational framework for simulating cardiovascular flows in patient specific anatomies
y curiosity into actual research projects. 1 believe that his advices will go a long way wit h me t hroughout, t he rest of my scientific advent lire.A COMPUTATIONAL FRAMEWORK FOR SIMULATING CARDIOVASCULAR FLOWS IN PATIENT-SPECIFIC ANATOMIESA DISSERTATIONSUBMITTED TO THE FACULTY OF THE GRADUATE SCHO Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies y course work, for giving mo kind advices on my research. 1'hanks extended to Dr. Kallmes at Mayo Clinic who provided me all the medical scanned images in t he aneurysm project . I would also like to thank Professor Yoganalhan at Georgia Tech, who provided me the experimental data for the left ventr Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies icle. Sincere thanks to Professor Webster at Georgia ’lech, Professor Longmire at Ư of Minnesota and Dr. Troolin at 'LSI for their dataset of the inclLuận văn a computational framework for simulating cardiovascular flows in patient specific anatomies
ined nozzle case, which intrigued me so much for its beauty and simplicity.Thanks to my friend, Iman Borazjani, who constantly gives me kind advices aA COMPUTATIONAL FRAMEWORK FOR SIMULATING CARDIOVASCULAR FLOWS IN PATIENT-SPECIFIC ANATOMIESA DISSERTATIONSUBMITTED TO THE FACULTY OF THE GRADUATE SCHO Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies oldebrhan, Ted Fuller, Man Liang. Vamsi Ganti and Mohammad Hajit. The members of my research group: Seokkoo Kang. Liang Ge, Cristian I’lscauriaza provided me lots of feedback from my research questions. 1 would like to thank all people at SAFL for being kind, supportive and empathetic.Finally. 1 wou Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies ld also like to acknow ledge Vietnam Education Foundation and United States National Academies for the fellowship, which provide me t he opport unityLuận văn a computational framework for simulating cardiovascular flows in patient specific anatomies
to expand my horizon on science. This work is also supported by grant -\1H K01-HL-07262, the Minnesota SuperCoinput i ng Institute ami Mayo Clinic.DedA COMPUTATIONAL FRAMEWORK FOR SIMULATING CARDIOVASCULAR FLOWS IN PATIENT-SPECIFIC ANATOMIESA DISSERTATIONSUBMITTED TO THE FACULTY OF THE GRADUATE SCHO Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies s to develop a computational framework for simulating cardiovascular Hows in patient-specific anatomies. The numerical method is based on the curvilinear immersed method approach and is able to simulate pulsatile flow in complex anatomical geometries, incorporates a novel, lum|>cd-paramelcr kinemati Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies c model of the left ventricle wall driven by electrical excitation, and can carry out fluid-structure interaction simulations between the blood flow aLuận văn a computational framework for simulating cardiovascular flows in patient specific anatomies
nd implanted bi-leallet mechanical heart valves (BMHV). The ability of the method to resolve and illuminate the physics of dynamically rich vortex pheA COMPUTATIONAL FRAMEWORK FOR SIMULATING CARDIOVASCULAR FLOWS IN PATIENT-SPECIFIC ANATOMIESA DISSERTATIONSUBMITTED TO THE FACULTY OF THE GRADUATE SCHO Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies mental measurements. The met hod is subsequently applied to simulate: 1) vortex formation and wall shear-stress dynamics inside an intracranial aneurysm; 2) the hemodynamics of early diastolic, filling in a patient-specific left ventricle (LV); and 3) and lluid-struciure interaction of a BMHV implan Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies ted in the aortic position of a patient-spccific LV/aorta configuration driven by electrical excitat ion of t he LV wall mot ion. For all cases the coLuận văn a computational framework for simulating cardiovascular flows in patient specific anatomies
mputed results yield new. clinically-rclevant insights into the underlying flow phenomena and underscore t he potential of t he numerical met hod as aA COMPUTATIONAL FRAMEWORK FOR SIMULATING CARDIOVASCULAR FLOWS IN PATIENT-SPECIFIC ANATOMIESA DISSERTATIONSUBMITTED TO THE FACULTY OF THE GRADUATE SCHO Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies ructure interaction scheme to simulate soft tissues and other medical devices, such as stents, bio-prosthetic tri-leaflet and percutaneous heart valves.iiiContentsAcknowledgementsiDedicationiiAbstractiiiList of TablesviiList of Figuresix1Introduction11.1Motivation ................................... Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies ....................... 11.2Literature review.................................................... 21.2.1In — vivo and In — vitro studies..............Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies
................. 21.2.2Computational studies.......................................... 31.3Thesis objectives and outlines............................A COMPUTATIONAL FRAMEWORK FOR SIMULATING CARDIOVASCULAR FLOWS IN PATIENT-SPECIFIC ANATOMIESA DISSERTATIONSUBMITTED TO THE FACULTY OF THE GRADUATE SCHO Luận văn a computational framework for simulating cardiovascular flows in patient specific anatomies rfluiddomain iiy ...12A COMPUTATIONAL FRAMEWORK FOR SIMULATING CARDIOVASCULAR FLOWS IN PATIENT-SPECIFIC ANATOMIESA DISSERTATIONSUBMITTED TO THE FACULTY OF THE GRADUATE SCHOGọi ngay
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