Economic studies of chronic kidney disease
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: Economic studies of chronic kidney disease
Economic studies of chronic kidney disease
|FJ QUEEN’SKl UNIVERSITYBELFASTECONOMIC STUDIES OFCHRONIC KIDNEY DISEASEA thesis submitted for the Degree ofDoctor of Philosophy (Ph.D.)to the Faculty Economic studies of chronic kidney disease y of Medicine. Health and Life Sciences School of Medicine, Dentistry and Biomedical Sciences Queen’s University BelfastbyNga TQ. Nguyen, BPharmSupervisors:Professor Ciaran O'NeillProfessor Michael Donnelly44105DECLARATIONI declare that:1rhe thesis is not one for which a degree has been or will be c Economic studies of chronic kidney disease onferred by any other university or institution:2The thesis is not one for which a degree has already been conferred by this University:.3. The work fEconomic studies of chronic kidney disease
or the thesis is my own work and that, where material submitted by me for another degree or work undertaken by me as part of a research group has been|FJ QUEEN’SKl UNIVERSITYBELFASTECONOMIC STUDIES OFCHRONIC KIDNEY DISEASEA thesis submitted for the Degree ofDoctor of Philosophy (Ph.D.)to the Faculty Economic studies of chronic kidney disease STRACTApproximately 9% of the global population has chronic kidney disease (CKD). Patients with end-stage renal disease (ESRD), the most advanced form of CKD. comprise 0.15% of the global population but consume 2-4% healthcare budgets. While the impact of CKD and ESRD are experienced most immediatel Economic studies of chronic kidney disease y by people with these diseases, the impact extends beyond them to include the healthcare system and wider society in terms of, for example, the costsEconomic studies of chronic kidney disease
and legal framework that are required to ensure good governance around organ donation. These impacts vary between countries, depending, inter alia, o|FJ QUEEN’SKl UNIVERSITYBELFASTECONOMIC STUDIES OFCHRONIC KIDNEY DISEASEA thesis submitted for the Degree ofDoctor of Philosophy (Ph.D.)to the Faculty Economic studies of chronic kidney disease . This PhD examined distinct aspects of these impacts across contexts using a variety of analytic approaches.Chapter 2 examined the relationship between health-related quality of life (HRQoL) and CKD severity, and the consequent economic impact due to reduced HRQoL among a representative sample of c Economic studies of chronic kidney disease ommunity dwelling adults in the United Kingdom. The evident decline in HRỌoL among people even with milder stages of CKD underscored the importance ofEconomic studies of chronic kidney disease
primary prevention, early diagnosis and secondary prevention in reducing the impact of CKD.As ESRD is expensive and access to renal replacement thera|FJ QUEEN’SKl UNIVERSITYBELFASTECONOMIC STUDIES OFCHRONIC KIDNEY DISEASEA thesis submitted for the Degree ofDoctor of Philosophy (Ph.D.)to the Faculty Economic studies of chronic kidney disease 3 examined disparities among ESRD inpatients taking into account changes in the policy context in the United States of America. Significant racial disparities regarding recorded anaemia, a modifiable and common complication of CKD. were observed. Not only did Native Americans as a group experience t Economic studies of chronic kidney disease he worst outcomes but their relative position declined after changes to policy. Chapter 3 underlined unintended consequences of policy changes that maEconomic studies of chronic kidney disease
y have been preventable.Complementing global efforts to address organ shortage. Chapter 4 examined attitudes (conceptualised in terms of passive suppo|FJ QUEEN’SKl UNIVERSITYBELFASTECONOMIC STUDIES OFCHRONIC KIDNEY DISEASEA thesis submitted for the Degree ofDoctor of Philosophy (Ph.D.)to the Faculty Economic studies of chronic kidney disease a mismatch and unobserved heterogeneity between passive iiand active support for tissue donation, was observed which underscored the importance of examining both types of support together in order to attain a more complete understanding about attitudes and how. potentially, they shape behaviours. C Economic studies of chronic kidney disease hapter 4 found the potential of incorporating both selfless and selfish motivations to translate latent passiv e into active support for donation.finaEconomic studies of chronic kidney disease
lly, despite the evident medical benefits of living donor kidney transplantation (Ĩ.DKT), there is limited information about the economic impact of Ĩ.|FJ QUEEN’SKl UNIVERSITYBELFASTECONOMIC STUDIES OFCHRONIC KIDNEY DISEASEA thesis submitted for the Degree ofDoctor of Philosophy (Ph.D.)to the Faculty Economic studies of chronic kidney disease nor rate, and considered the implications of the program’s evolution for future cost-effectiveness studies. Using the linked data provided by the Belfast Health and Social Care (11SC) Trust and the Northern Ireland HSC Business Service Organization. Chapter 5 demonstrated the superiority of LDK.T ov Economic studies of chronic kidney disease er deceased donor kidney transplantations in terms of survival outcomes. Furthermore, it demonstrated how this superiority persisted, despite the incrEconomic studies of chronic kidney disease
easing complexity of case mix over time. The chapter concluded by presenting a road map for a subsequent fill 1 economic evaluation of the LDKT progra|FJ QUEEN’SKl UNIVERSITYBELFASTECONOMIC STUDIES OFCHRONIC KIDNEY DISEASEA thesis submitted for the Degree ofDoctor of Philosophy (Ph.D.)to the Faculty Economic studies of chronic kidney disease o address the organ shortage crisis and the implication of program evolution for costeffectiveness analyses.iiiACKNOWLEDGEMENTFirst and foremost. I would like to express my greatest gratitude to my two supervisors Prof. Ciaran O’Neill and Prof. Michael Donnelly. You are the best supervisors I could Economic studies of chronic kidney disease ever wish for. thank you for your invaluable guidance and immeasurable support, your encouragement and patience, and your positive energy that have fuEconomic studies of chronic kidney disease
lfilled my PhD journey. What you have taught me sets a steady foundation for my future career.I am also grateful to the late Prof. Liam Murray who ope|FJ QUEEN’SKl UNIVERSITYBELFASTECONOMIC STUDIES OFCHRONIC KIDNEY DISEASEA thesis submitted for the Degree ofDoctor of Philosophy (Ph.D.)to the Faculty Economic studies of chronic kidney disease you for your continuous support.My thesis as well as the other research I have been involved in have been considerably-improved thanks to many of the collaborators. I would like to send especial thanks to Prof. Peter Maxwell. Dr. Aisling Courtney. Dr. Michael Quinn, and Dr. Grainne Crealey for your Economic studies of chronic kidney disease expertise and advice.|FJ QUEEN’SKl UNIVERSITYBELFASTECONOMIC STUDIES OFCHRONIC KIDNEY DISEASEA thesis submitted for the Degree ofDoctor of Philosophy (Ph.D.)to the Faculty|FJ QUEEN’SKl UNIVERSITYBELFASTECONOMIC STUDIES OFCHRONIC KIDNEY DISEASEA thesis submitted for the Degree ofDoctor of Philosophy (Ph.D.)to the FacultyGọi ngay
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