Toxicity assessment of small molecules using the zebrafish as a model system sinh học
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: Toxicity assessment of small molecules using the zebrafish as a model system sinh học
Toxicity assessment of small molecules using the zebrafish as a model system sinh học
VIETNAM NATIONAL UNIVERSITY. HANOI INSTITUTE OF MICROBIOLOGY AND BIOTECHNOLOGY and UNIVERSITY OF LIÈGE Dinh Duy Thành TOXICITY ASSESSMENT OF SMALL MOI Toxicity assessment of small molecules using the zebrafish as a model system sinh học I.EC ( LES USING HIE ZEBRAFISH AS A MODEL SYSTEMSubject: Biotechnology Code:60.42.02.01 MASTER’S THESIS SUPERVISORS: Prof. Marc Muller Dr. Nguyen Lai Thành Hà Nội-2014ACKNOW UEVGĩMĩNTThis thesis would not have been possible without all the support, guidance, inspiration, and patience of the followin Toxicity assessment of small molecules using the zebrafish as a model system sinh học g people and organisations during the course of my study. It is a privilege to convey my gratefulness to them in my humble acknowledgements.First andToxicity assessment of small molecules using the zebrafish as a model system sinh học
foremost, 1 own my deepest gratitude to Prof. Marc Muller, who gave me the opportunity to pursue my own interests as a trainee in the GIGA-Research. YVIETNAM NATIONAL UNIVERSITY. HANOI INSTITUTE OF MICROBIOLOGY AND BIOTECHNOLOGY and UNIVERSITY OF LIÈGE Dinh Duy Thành TOXICITY ASSESSMENT OF SMALL MOI Toxicity assessment of small molecules using the zebrafish as a model system sinh học you did motivate me through my inner pressures as well as outer obstacles.Ỉ offer my thankfulness to my co-supervisor, Dr. Nguyễn Lai Thành, for continuously encouraging me to explore my own ideas. Your knowledge, gentleness, and trust have inspired me and other students to keep following the scient Toxicity assessment of small molecules using the zebrafish as a model system sinh học ific path.Special thanks to Dr. Nguyền Huỳnh Minh Quyên, Prof. Jacques Dommes, the Institute of Microbiology and Biotechnology (VNƯ-IMBT), and the UniToxicity assessment of small molecules using the zebrafish as a model system sinh học
versity of Liège (ULg) for organising this Master Program in Biotechnology. It is also an honour for me toistudy with devoted professors and lectures VIETNAM NATIONAL UNIVERSITY. HANOI INSTITUTE OF MICROBIOLOGY AND BIOTECHNOLOGY and UNIVERSITY OF LIÈGE Dinh Duy Thành TOXICITY ASSESSMENT OF SMALL MOI Toxicity assessment of small molecules using the zebrafish as a model system sinh học , Yoann, and Audrey in the Toxicology team as well as the Mullerians and members of the BMGG: Thomas, Marie, David, and all others. Your supports and helps during my stay in Liège crucially contributed to the completion of my research. Ỉ would also like to express my thanks to my friends and colleag Toxicity assessment of small molecules using the zebrafish as a model system sinh học ues: Lung, Tuan, An, Loan, and others for their cares and encouragements in life and work.My research trip was co-sponsored by the Wallonia-Brussels IToxicity assessment of small molecules using the zebrafish as a model system sinh học
nternational (WBĨ) and the Wallonia-Brussels delegation to Vietnam. Ỉ would like to thank you for your commitment to supporting scientific innovationsVIETNAM NATIONAL UNIVERSITY. HANOI INSTITUTE OF MICROBIOLOGY AND BIOTECHNOLOGY and UNIVERSITY OF LIÈGE Dinh Duy Thành TOXICITY ASSESSMENT OF SMALL MOI Toxicity assessment of small molecules using the zebrafish as a model system sinh học on and gratitude are dedicated to my dear family, particularly my beloved wife for unconditionally trusting and pushing me to overcome all kinds of difficulty Ỉ encounter in the past, present, and future.iiTABLE OF CONTENTSTABLE OF CONTENTS................................................iLIST OF TAB Toxicity assessment of small molecules using the zebrafish as a model system sinh học LES AND FIGURES.......................................VABBREVIATIONS..................................................viiPREFACE......................Toxicity assessment of small molecules using the zebrafish as a model system sinh học
....................................1Chapter 1: BACKGROUND INFORMATION................................2/./. Small molecules: safety' concerns.........VIETNAM NATIONAL UNIVERSITY. HANOI INSTITUTE OF MICROBIOLOGY AND BIOTECHNOLOGY and UNIVERSITY OF LIÈGE Dinh Duy Thành TOXICITY ASSESSMENT OF SMALL MOI Toxicity assessment of small molecules using the zebrafish as a model system sinh học ehold chemicals...................................51.2.The Zebrafish embryo toxicity test (ZPT)..................6Chapter 2: METHODS..............................................112. 1. Substances.............................................ì 12.2.Zebrafish maintenance............................... Toxicity assessment of small molecules using the zebrafish as a model system sinh học .....122.3.Chemical exposure and embryo observation.................122.4.Behavioural analysis.....................................142.5.Gene expressiToxicity assessment of small molecules using the zebrafish as a model system sinh học
on analysis.................................142.5.1.Reverse transcription and quantitative polymerase chain reaction.142.5.2.Transgenic fluorescent liVIETNAM NATIONAL UNIVERSITY. HANOI INSTITUTE OF MICROBIOLOGY AND BIOTECHNOLOGY and UNIVERSITY OF LIÈGE Dinh Duy Thành TOXICITY ASSESSMENT OF SMALL MOI Toxicity assessment of small molecules using the zebrafish as a model system sinh học ....17Chapter 3: RESULTS AND DISCUSSION...............................18VIETNAM NATIONAL UNIVERSITY. HANOI INSTITUTE OF MICROBIOLOGY AND BIOTECHNOLOGY and UNIVERSITY OF LIÈGE Dinh Duy Thành TOXICITY ASSESSMENT OF SMALL MOIGọi ngay
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