Epigenetic reduction of DNA repair in progression to gastrointestinal cancer
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Epigenetic reduction of DNA repair in progression to gastrointestinal cancer
(Ị 0World Journal ofGastrointestinal OncologyEpigenetic reduction of DNA repair in progression to gastrointestinal cancerCarol Bernstein, Harris Berns Epigenetic reduction of DNA repair in progression to gastrointestinal cancersteinCITATIONBernstein c, Bernstein H. Epigenetic reduction of DNA repair in progression to gastrointestinal cancer. World J Gastrointest Oncol 2015; 7(5): 30-46URLhttp://www.wjgnet.com/1948-5204/full/v7/i5/30.htmDOIhttp://dx.doi.org/10.4251/wjgo.v7.i5.30OPEN ACCESSThis article is an open-access art Epigenetic reduction of DNA repair in progression to gastrointestinal cancericle which was selected by an inhouse editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative CommonsEpigenetic reduction of DNA repair in progression to gastrointestinal cancer
Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and licens(Ị 0World Journal ofGastrointestinal OncologyEpigenetic reduction of DNA repair in progression to gastrointestinal cancerCarol Bernstein, Harris Berns Epigenetic reduction of DNA repair in progression to gastrointestinal cancerrg/licenses/by-nc/4.0/CORE TIPThe primary cause of cancer is DNA damage. DNA damage leads to replication errors and erroneous repair, and can result in driver mutations and epimutations. While germ-line mutations in DNA repair genes cause cancer-prone syndromes, mutations in DNA repair genes are inf Epigenetic reduction of DNA repair in progression to gastrointestinal cancerrequent in sporadic gastrointestinal cancers. However, reduction of DNA repair proteins due to epigenetic repression of DNA repair genes is very frequEpigenetic reduction of DNA repair in progression to gastrointestinal cancer
ent and can cause early steps in sporadic cancers. Evaluation of which DNA repair pathway(s) are deficient in particular types of Gl cancer and/or par(Ị 0World Journal ofGastrointestinal OncologyEpigenetic reduction of DNA repair in progression to gastrointestinal cancerCarol Bernstein, Harris Berns Epigenetic reduction of DNA repair in progression to gastrointestinal cancers; Epimutation; Genomic instability; Germ-line mutation;MicroRNAs; Precancerous conditions; Gastrointestinal cancerCOPYRIGHT© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.COPYRIGHT LICENSEOrder reprints or request permissions: bpgoffice(S) wjgnet.comNAME OF J Epigenetic reduction of DNA repair in progression to gastrointestinal cancerOURNALWorld Journal of Gastrointestinal OncologyISSN1948-5204 ( online)PUBLISHERPublished by Baishideng Publishing Group Inc, 8226 Regency Drive, PleaEpigenetic reduction of DNA repair in progression to gastrointestinal cancer
santon, CA 94588, USAWEBSITEhttp://www.wjgnet.comESPS Manuscript NO: 15877Columns: EDITORIALEpigenetic reduction of DNA repair in progression to gastr(Ị 0World Journal ofGastrointestinal OncologyEpigenetic reduction of DNA repair in progression to gastrointestinal cancerCarol Bernstein, Harris Berns Epigenetic reduction of DNA repair in progression to gastrointestinal cancerne, University of Arizona, Tucson, AZ 85724, United StatesAuthor contributions: Both authors contributed to this manuscript. Conflict-of-interest: The authors have no conflicts of interest. Carol Bernstein has no conflicts of interest. Harris Bernstein has no conflicts of interest.Open-Access: This Epigenetic reduction of DNA repair in progression to gastrointestinal cancerarticle is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordaEpigenetic reduction of DNA repair in progression to gastrointestinal cancer
nce with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this wor(Ị 0World Journal ofGastrointestinal OncologyEpigenetic reduction of DNA repair in progression to gastrointestinal cancerCarol Bernstein, Harris Berns Epigenetic reduction of DNA repair in progression to gastrointestinal cancerSee: http://creativecommons.Org/licenses/by-nc/4.0/ Correspondence to: Carol Bernstein, Research Associate Professor, Department of Cellular and Molecular Medicine, College of Medicine, University of Arizona, Tucson, AZ 85724, United States.bernstein324@yahoo.comTelephone: +1-520-2415260Received: De Epigenetic reduction of DNA repair in progression to gastrointestinal cancercember 14, 2014Peer-review started: December 16, 2014First decision: March 6, 2015Revised: April 4, 2015Accepted: April 16, 2015Article in press: ApriEpigenetic reduction of DNA repair in progression to gastrointestinal cancer
l 20, 2015 Published online: May 15, 2015AbstractDeficiencies in DNA repair due to inherited germ-line mutations in DNA repair genes cause increased r(Ị 0World Journal ofGastrointestinal OncologyEpigenetic reduction of DNA repair in progression to gastrointestinal cancerCarol Bernstein, Harris Berns Epigenetic reduction of DNA repair in progression to gastrointestinal cancereduce expression of DNA repair genes are frequent in sporadic Gl cancers. These epigenetic reductions are also found in field defects that give rise to cancers. Reduced DNA repair likely allows excessive DNA damages to accumulate in somatic cells. Then either inaccurate translesion synthesis past th Epigenetic reduction of DNA repair in progression to gastrointestinal cancere un-repaired DNA damages or error-prone DNA repair can cause mutations. Erroneous DNA repair can also cause epigenetic alterations (i.e., epimutationEpigenetic reduction of DNA repair in progression to gastrointestinal cancer
s, transmitted through multiple replication cycles). Some of these mutations and epimutations may cause progression to cancer. Thus, deficient or abse(Ị 0World Journal ofGastrointestinal OncologyEpigenetic reduction of DNA repair in progression to gastrointestinal cancerCarol Bernstein, Harris Berns Epigenetic reduction of DNA repair in progression to gastrointestinal cancersands of mutations occur in these cancers. Epimutations that reduce DNA repair gene expression and occur early in progression to Gl cancers are a likely source of this high genomic instability. Cancer cells deficient in DNA repair are more Epigenetic reduction of DNA repair in progression to gastrointestinal cancer(Ị 0World Journal ofGastrointestinal OncologyEpigenetic reduction of DNA repair in progression to gastrointestinal cancerCarol Bernstein, Harris BernsGọi ngay
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