SYNTHESIS OF THIOFLAVIN T ANALOGUES

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SYNTHESIS OF THIOFLAVIN T ANALOGUES

University of Rhode IslandDigitalCommons@URIOpen Access Master's Theses2018SYNTHESIS OF THIOFLAVIN T ANALOGUESJennifer RodríguezUniversity of Rhode Is

SYNTHESIS OF THIOFLAVIN T ANALOGUESsland. jrodrig6(aimy.uri.eduFollow this and additional works at: https://digitalcommons.uri.edu/thesesRecommended CitationRodríguez, Jennifer, 'SYNTHE

SIS OF THIOFLAVIN T ANALOGUES' (2018). open Access Master's Theses.Paper 1413.https://digitalcommons.uri edu/theses/1413This Thesis is brought to you SYNTHESIS OF THIOFLAVIN T ANALOGUES

for free and open access by DigitalCommons@URl. It has been accepted for inclusion in Open Access Master's Theses by an authorized administrator of Di

SYNTHESIS OF THIOFLAVIN T ANALOGUES

gitalCommons;gURl. For more information, please contact digitalcommons@etai uri edu.SYNTHESIS OF THIOFLAVIN T ANALOGUESBYJENNIFER TERESA XAVIER RODRÍG

University of Rhode IslandDigitalCommons@URIOpen Access Master's Theses2018SYNTHESIS OF THIOFLAVIN T ANALOGUESJennifer RodríguezUniversity of Rhode Is

SYNTHESIS OF THIOFLAVIN T ANALOGUESDE ISLAND2018MASTER OI SCIENCEorJENNIFER TERESA XAVTF.R RODRÍGUEZAPPROVED:Thesis Committee:Major Professor Brenton DeBoefAl BachFrank Menn it!Nasser H

. ZawiaDEAN OF THE GRADUATE SCHOOLUNIVERSITY or RHODE ISLAND2018ABSTRACTAlzheimer’s disease is the most prevalent form of dementia and is characterize SYNTHESIS OF THIOFLAVIN T ANALOGUES

d by the presence of beta-amyloid plaques and tau tangles. Thioflavin-T. a fluorescent molecule, is known to have a high binding affinity to beta-amyl

SYNTHESIS OF THIOFLAVIN T ANALOGUES

oid. The high binding association is optimal for use as an affinity tag in the synthesis of targeted molecular imaging probes for detection by hyperpo

University of Rhode IslandDigitalCommons@URIOpen Access Master's Theses2018SYNTHESIS OF THIOFLAVIN T ANALOGUESJennifer RodríguezUniversity of Rhode Is

SYNTHESIS OF THIOFLAVIN T ANALOGUESld up in numerous organs. The goal of this project was to synthesize six Thioflavin-T analogues that could have greater binding associations and poten

tially be used to construct xenon probes. The six analogues were synthesized. SYNTHESIS OF THIOFLAVIN T ANALOGUES

University of Rhode IslandDigitalCommons@URIOpen Access Master's Theses2018SYNTHESIS OF THIOFLAVIN T ANALOGUESJennifer RodríguezUniversity of Rhode Is