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Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2

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Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2

12SOFT TISSUE LESIONS WITH CLEAR OR GRANULAR CELLSINTRODUCTIONClear cell change can be seen in sonic examples of myoepithelioma (Chapter 6), smooth mu

Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2uscle tumors (Chapter 7), atypical fibroxanthoma (Chapter 13), Ewing sarcoma (Chapter 14), rhabdomyosarcoma (Chapter 14), and gastrointestinal stromal

tumor (Chapter 5). Tumors in which clear cell change can be predominant include glomus tumor (Chapter 7), alveolar soft part sarcoma, clear cell sarc Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2

oma, PEComa, and paraganglioma, as well as metastases from other organs including carcinomas. Lesions with lipoblastic and pseudolipoblastic different

Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2

iation can also enter the differential diagnosis and are discussed in Chapter 15. Granular cell or oncocytic change is seen in granular cell tumor, an

12SOFT TISSUE LESIONS WITH CLEAR OR GRANULAR CELLSINTRODUCTIONClear cell change can be seen in sonic examples of myoepithelioma (Chapter 6), smooth mu

Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2broma (Chapter 4), dermatofibrosarcoma protuberans (Chapter 4), atypical fibroxanthoma (Chapter 13), and benign and malignant PEComas. Finally, reacti

ve and neoplastic histiocytic proliferations can present in soft tissue as clear or granular cell tumors. The differential diagnoses arc summarized in Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2

Tables 12.1 and 12.2.CLEAR CELL SARCOMA OF SOFT TISSUEClinical FeaturesThis is a tumor of young adults (more often in females) that arises predominan

Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2

tly in the extremities, especially the foot and rarely in trunk or head and neck sites as a slowly growing firm mass. The usual location is deep subcu

12SOFT TISSUE LESIONS WITH CLEAR OR GRANULAR CELLSINTRODUCTIONClear cell change can be seen in sonic examples of myoepithelioma (Chapter 6), smooth mu

Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2lung and bone, with survival rates of 67%, 33%, and 10% after 5, 10, and 15 years, respectively.1,2 A genetically distinct subset of clear cell sarcom

a arises in the gastrointestinal tract, where it presents with obstruction, bleeding, or mass effect. Neither subtype is related to clear cell sarcoma Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2

of kidney.256TABLE 12.1Differential Diagnosis of Clear Cell and Granular Cell TumorsTypical Clinical Features Microscopic FeaturesClear cell cutaneou

Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2

s fibrous histiocytomaClear cell atypical fibroxanthomaRaised firm nodule on extremities, young adultsSun-exposed areas, elderly patientsEpidermal hyp

12SOFT TISSUE LESIONS WITH CLEAR OR GRANULAR CELLSINTRODUCTIONClear cell change can be seen in sonic examples of myoepithelioma (Chapter 6), smooth mu

Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2ying fibromyxoid tumorSubcutaneous well-demarcated nodule, any ageClear cell sarcoma (soft tissue)Extremities especially lower limb, young adults. In

subcutis or deeper tissue, it involves tendons. Subset in Gl tractPartial shell of bone in many, thick fibrous capsule, cords of rounded glomus-like o Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2

r occasionally spindled cells, fibromyxoid stroma. Atypical variant can have increased cellularity, mitoses, intralesional osteoidNested pattern, roun

Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2

d nuclei with central nucleolus, clear or granular cytoplasm, sometimes spindling, multinucleated cells, melanin pigment. No junctional activityAncill

12SOFT TISSUE LESIONS WITH CLEAR OR GRANULAR CELLSINTRODUCTIONClear cell change can be seen in sonic examples of myoepithelioma (Chapter 6), smooth mu

Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2A* in some, rarely CK+Granular cell tumorSubcutaneous in adults, especially in head and neck sites. Also in various organsInfiltrative sheets and cord

s of large polygonal cells, coarsely granular cytoplasm. Clear cell areas often present alsoS100 protein*, HMB45+ and melan-A* (except in Gl tract), o Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2

ther markers negative t(12;22) (ql3;ql2), EWSR1-ATF1 or t (2;22)(q33;qi2), EWSR1-CREB1 (mostly GI cases)S100 protein*, CD68+, CEA*(Continued)SOFT TISS

Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2

UE LESIONS WITH CLEAR OR GRANULAR CELLS- 257Differential Diagnosis of Clear Cell and Granular Cell Tumors (Continued) IM*™'typical Clinical FeaturesMi

12SOFT TISSUE LESIONS WITH CLEAR OR GRANULAR CELLSINTRODUCTIONClear cell change can be seen in sonic examples of myoepithelioma (Chapter 6), smooth mu

Ebook Biopsy interpretation series - Biopsy interpretation of soft tissue tumors: Part 2nd superficial subcutis. Areas of typical dermatofibrosarcoma usually present, with transitional formsCD34+, S100 protein-

12SOFT TISSUE LESIONS WITH CLEAR OR GRANULAR CELLSINTRODUCTIONClear cell change can be seen in sonic examples of myoepithelioma (Chapter 6), smooth mu

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