Ebook Essentials of biochemistry: Part 2
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: Ebook Essentials of biochemistry: Part 2
Ebook Essentials of biochemistry: Part 2
Chapter 8Carbohydrate Metabolism A: Glycolysis and GluconeogenesisGlycolysis is defined as the anerobic conversion of glucose to pyruvic acid. The gly Ebook Essentials of biochemistry: Part 2ycolytic pathway, which is ubiquitous in nature, is also known as the Meycrhoff, Embden. Parnas pathway, named after the three biochemists who made major contributions to its formulation. The physiological role played by glycolysis in the cell far exceeds just the biosynthesis of pyruvate, e.g., it Ebook Essentials of biochemistry: Part 2provides the cell with ATP under anerobic conditions and it also supplies precursors for the biosynthesis of proteins, lipids, nucleic acids, and polyEbook Essentials of biochemistry: Part 2
saccharides.The enzymes involved in glycolysis, ten in number, are water soluble and arc found in the cell cytoplasm. Historically, these enzymes haveChapter 8Carbohydrate Metabolism A: Glycolysis and GluconeogenesisGlycolysis is defined as the anerobic conversion of glucose to pyruvic acid. The gly Ebook Essentials of biochemistry: Part 2re regulated by small molecules. The primary regulatory enzymes in this pathway arc phosphofructoki-nasC| (PFK|) and pyruvate kinase, hl some tissues hexokinase is also a regulated enzyme, e.g.. it has been called the "pacemaker of glycolysis" in brain and the red blood cell. In most mammalian tissu Ebook Essentials of biochemistry: Part 2es, however, hexokinase is not a regulated enzyme.8.1 GlycolysisFigure 8.1 illustrates the glycolytic metabolic pathway.In Fig. 8.1 there are three thEbook Essentials of biochemistry: Part 2
ermodynamically irreversible steps, i.e., reactions where the A6" is highly negative. These reactions involve the enzymes hexokinase, phosphofructokinChapter 8Carbohydrate Metabolism A: Glycolysis and GluconeogenesisGlycolysis is defined as the anerobic conversion of glucose to pyruvic acid. The gly Ebook Essentials of biochemistry: Part 2DH 4- 2ATP4’ 4-2H+.In terms of energetics, four ATP molecules arc synthesized; two at the phosphoglycerate kinase step and two more when phosphoenol pyruvate is converted toH.J. Fromm and M.S. Hargrove. Essentials of B ioche mis fry.163ruil in 1007/070.1 OÁ7/1.O « c Cnrinnor.Vorlifl Berlin70171648 C Ebook Essentials of biochemistry: Part 2arbohydrate Metabolism A: Glycolysis and GluconeogenesisHOHATP ADP,,H o H OHD-glucose(hexokinase)hOPO5H-CHiH0HO HOH.H oh°hD-glucose-6-PCfe H o(phosphoEbook Essentials of biochemistry: Part 2
hexose isomerase)ADPATPCHựyPO-iH’ (phosphofructokinase,)3(PFK-1)CH^POjjH’‘(Cy\H HO/1HI IOH HChapter 8Carbohydrate Metabolism A: Glycolysis and GluconeogenesisGlycolysis is defined as the anerobic conversion of glucose to pyruvic acid. The glyChapter 8Carbohydrate Metabolism A: Glycolysis and GluconeogenesisGlycolysis is defined as the anerobic conversion of glucose to pyruvic acid. The glyGọi ngay
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