Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2
Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2
Chapter 22Histamine ModulatorsMichael Yarborough and Judy G. JohnsonContentsIntroduction.............................................................. Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2............. 365Drug Class and Mechanism of Action.................................................... 366Indications and Clinical Pearls....................................................... 367Drug Interactions/Side Effects/Black Box Warnings..................................... 374Cardiac Effec Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2ts................................................................... 374CNS Effects..................................................................Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2
..... 375Summary............................................................................... 377Chemical Structures................................Chapter 22Histamine ModulatorsMichael Yarborough and Judy G. JohnsonContentsIntroduction.............................................................. Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2 of certain chemicals to counteract the effects of histamine occurred in the early twentieth century'. The development of a drug that would alleviate allergic reactions such as itchy, watery eyes, and a runny nose from a cold or hay fever had an astronomical effect on the medical community. By the 1 Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2950s. antihistamines were being mass-produced in the USA and prescribed extensively as the drug of choice for those suffering from allergies. The publEbook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2
ic perceived antihistamines as the “wonder drug" and with the misconception that it was a “cure all” to the common cold. Eventually, scientist began tChapter 22Histamine ModulatorsMichael Yarborough and Judy G. JohnsonContentsIntroduction.............................................................. Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2local pharmacies. However, the plethora of roles that antihistamines play in the treatment of the human condition is much more extensive, including suppression of allergy symptoms, sedative agents, and antiemetic actions to name a few.M. Yarborough. MDDepartment of Anesthesiology. Tulane Medical Cen Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2ter. New Orleans. LA. USAe-mail: myarboro@tulane.eduJ.G. Johnson, MD (El)Department of Anesthesiology. Louisiana State University. New Orleans. LA. USEbook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2
AA.D. Kaye et al. (eds.). Essentials of Pharmacology for Anesthesia,365Pain Medicine, and Critical Care. DOI 10.1007/978-1 -4614-8948-1 _22.366M. YarbChapter 22Histamine ModulatorsMichael Yarborough and Judy G. JohnsonContentsIntroduction.............................................................. Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2s in the gut. It can also act as a neurotransmitter. Histamine is made and released by different cells, i.e.. basophils, mast cells, platelets, histaminergic neurons, lymphocytes, and enterochromaffin cells. It is stored in vesicles or granules awaiting release upon stimulation [1]. As part of an im Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2mune response to foreign pathogens, histamine increases the permeability of capillaries to white blood cells and other proteins in order to allow themEbook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2
to engage foreign invaders in the infected tissues. Clinical effects of histamine result in increased vascular permeability and leakage of plasma proChapter 22Histamine ModulatorsMichael Yarborough and Judy G. JohnsonContentsIntroduction.............................................................. Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2ash, itching, puffy and watery eyes, nasal congestion, and rhinorrhea.There are four known human histamine receptors that have been identified (Table 22.1). These receptors belong to the G-protein-coupled receptors family. They are signified as H|, H2. Hj. and H4. Stimulation of the H| receptor can Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2activate intracellular signaling pathways leading to the development of classic allergic symptoms [ 1 ].Historically, antihistamines were noted to cauEbook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2
se a parallel displacement in the histamine concentration/rcsponse. This behavior was consistent with a competitive inhibition for histamine receptorsChapter 22Histamine ModulatorsMichael Yarborough and Judy G. JohnsonContentsIntroduction.............................................................. Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2now called inverse agonistsTable 22.1 Histamine receptors classificationReceptor typeTissue locationIntracellular functionHiAirway and vascular smooth muscles, endothelial, central nervous system (nerve cells), neutrophils, eosinophils, monocytesCause bronchial smooth muscle contraction, separation Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2of endothelial cells causing hives, pain, and itching. Allergic reaction symptoms, motion sickness, and regulation of sleeph2Nerxe cells, vascular smoEbook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2
oth muscles and parietal cells, hepatocytes, endothelial cells, epithelial cells, neutrophils, eosinophils, monocytesVasodilation and stimulation of gChapter 22Histamine ModulatorsMichael Yarborough and Judy G. JohnsonContentsIntroduction.............................................................. Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2 histamine release and synthesis. Decreases release of serotonin, acetylcholine, and norepinephrineh4High expression in bone marrow and peripheral hematopoietic cells. Low expression in nerve cells, hepatocytes, spleen, thymus, small intestine, colon, heartStimulates chemotaxis of eosinophils and ma Ebook Essentials of pharmacology for anesthesia, pain medicine and critical care: Part 2st cells22 Histamine Modulators367Chapter 22Histamine ModulatorsMichael Yarborough and Judy G. JohnsonContentsIntroduction..............................................................Chapter 22Histamine ModulatorsMichael Yarborough and Judy G. JohnsonContentsIntroduction..............................................................Gọi ngay
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