Ebook Oxford handbook of endocrinology and diabetes (3rd edition): Part

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Ebook Oxford handbook of endocrinology and diabetes (3rd edition): Part

Chapter 5425Endocrinology in pregnancyThyroid and parathyroid disorders 426Maternal hyperthyroidism 428Maternal hypothyroidism 431Post-partum thyroid

Ebook Oxford handbook of endocrinology and diabetes (3rd edition): Part dysfunction 432Thyroid cancer in pregnancy 433Parathyroid disorders 434Pituitary disorders 436Prolactinoma in pregnancy 437Management of prolactinoma

438Cushing’s syndrome 439Management of Cushing’s syndrome 440Acromegaly 441Non-functioning pituitary tumours 441Hypopituitarism in pregnancy 442Adren Ebook Oxford handbook of endocrinology and diabetes (3rd edition): Part

al disorders 444Addison’s disease in pregnancy 445Congenital adrenal hyperplasia 446Phaeochromocytoma 447Management of phaeochromocytoma 448426 CHAPTE

Ebook Oxford handbook of endocrinology and diabetes (3rd edition): Part

RS Endocrinology in pregnancyThyroid and parathyroid disordersNormal physiologyEffect of pregnancy on thyroid function•Iodine stores. Fall due to t re

Chapter 5425Endocrinology in pregnancyThyroid and parathyroid disorders 426Maternal hyperthyroidism 428Maternal hypothyroidism 431Post-partum thyroid

Ebook Oxford handbook of endocrinology and diabetes (3rd edition): Partciency.•Thyroglobulin. Rise corresponds to rise in thyroid size.•Thyroid-binding globulin (TBG). Twofold t in concentration as a result of reduced hep

atic clearance, and t synthesis stimulated by oestrogen. Concentration plateaus at 20 weeks' gestation and falls again post-partum.•Total Tj and T.,.t Ebook Oxford handbook of endocrinology and diabetes (3rd edition): Part

concentrations, corresponding to rise in TBG.•Free T4 and Tỵ There may be a small rise in concentration in first trimester due to hCG stimulation, th

Ebook Oxford handbook of endocrinology and diabetes (3rd edition): Part

en fall into normal range. During second and third trimester, FT4 concentration is often just below the normal reference range.•Thyroid-stimulating ho

Chapter 5425Endocrinology in pregnancyThyroid and parathyroid disorders 426Maternal hyperthyroidism 428Maternal hypothyroidism 431Post-partum thyroid

Ebook Oxford handbook of endocrinology and diabetes (3rd edition): Part due to hCG thyrotropic effect. +ve correlation between free T4 and hCG levels, and -ve correlation between TSH and hCG levels in first half of pregna

ncy, upper limit of normal range is higher in pregnancy.•Thyrotropin-releasing hormone (TRH). Normal.•TSH receptor antibodies. When present in high co Ebook Oxford handbook of endocrinology and diabetes (3rd edition): Part

ncentrations in maternal serum, may cross the placenta. Antibody titre decreases with progression of pregnancy.Fetal thyroid function•TRH and TSH synt

Ebook Oxford handbook of endocrinology and diabetes (3rd edition): Part

hesis occurs by 8-10 weeks’ gestation, and thyroid hormone synthesis occurs by 10-12 weeks' gestation.

Chapter 5425Endocrinology in pregnancyThyroid and parathyroid disorders 426Maternal hyperthyroidism 428Maternal hypothyroidism 431Post-partum thyroid