Ebook Textbook of biochemistry (7E): Part 2
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Ebook Textbook of biochemistry (7E): Part 2
CHAPTER 29Acid-BaseBalance and pHChapter at a GlanceThe reader will be able to answer questions on the following topics:>Acids and bases>Renal regulat Ebook Textbook of biochemistry (7E): Part 2tion of pHs'pHRelation of pH and potassium>Buffers>Respiratory acidosis>Acid base balance in the body>Metabolic acidosisBicarbonate buffer systemRespiratory alkalosis>Respiratory regulation of pH>Metabolic alkalosisHydrogen ions (H") are present in all body compartments. Maintenance of appropriate c Ebook Textbook of biochemistry (7E): Part 2oncenuation of hydrogen ion (IP) is critical to normal cellular function. The acid-base balance or pH of the body fluids is maintained by a closely reEbook Textbook of biochemistry (7E): Part 2
gulated mechanism. This involves the body buffers, the respiratory system and the kidney. Some common definitions are given in Box 29.1. Functions of CHAPTER 29Acid-BaseBalance and pHChapter at a GlanceThe reader will be able to answer questions on the following topics:>Acids and bases>Renal regulat Ebook Textbook of biochemistry (7E): Part 2orylation.2.The surface chai ge and physical configuration of proteins are affected by changes U1 hydrogen ion concentration.3.Hydrogen ion concentration decides the ionization of weak acids and thus affects then physiological functions.I ACIDS AND BASESDefinitionThe electrolyte theory of dissociati Ebook Textbook of biochemistry (7E): Part 2on was proposed by Arrhenius (Nobel prize. 1903). According to the definition proposed by Bronsted. acids are substances that areSPL Sorensen 1868-193Ebook Textbook of biochemistry (7E): Part 2
9Svante Arrhenius NP 1903 1859-1927Johannes NBronsted 1879-1947Chaplet 29; Ac id - Base Balante and pH391capable of donating protons and bases are thoCHAPTER 29Acid-BaseBalance and pHChapter at a GlanceThe reader will be able to answer questions on the following topics:>Acids and bases>Renal regulat Ebook Textbook of biochemistry (7E): Part 2 x IT + Cl - HCO/+H K - * H,co,iijCO,ir + IICO/Weak and strong Acidsi.Tlieexlent of dissociation decides whelhci they aivsliung acids or weak acids. Strong acids dissociate completely in solution, while weak acids ionize incompletely, for example.HC1 ---------> H- + Cl (Complete)H,COj . H- HCOj (Par Ebook Textbook of biochemistry (7E): Part 2tial)ii.Tn a solution of TTC1. almost all the molecules dissociate and exist as IT* and Cl ions. Hence the concentration of H' IS very high and It isEbook Textbook of biochemistry (7E): Part 2
a strong acid.iii.Bill in the case ofa weak acid (c.g. acetic acid), it will ionize only partially. So. the number of acid molecules existing in the iCHAPTER 29Acid-BaseBalance and pHChapter at a GlanceThe reader will be able to answer questions on the following topics:>Acids and bases>Renal regulat Ebook Textbook of biochemistry (7E): Part 2e ratio between dissociated and undissociated particle is a constant. The dissociation constant (Ka) of an acid is given by the formula.CHAPTER 29Acid-BaseBalance and pHChapter at a GlanceThe reader will be able to answer questions on the following topics:>Acids and bases>Renal regulatGọi ngay
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