Ebook The biology of cancer (2/E): Part 2
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Ebook The biology of cancer (2/E): Part 2
Chapter 9p53 and Apoptosis: Master Guardian and ExecutionerTo examine rhe causes of life, we must fret have recourse to death,Mary Shelley. FfEbook The biology of cancer (2/E): Part 2
n serves as the local representative ofthe organisms interests, p53 is present onsite to ensure that the cell keeps its household in order.If p53 receChapter 9p53 and Apoptosis: Master Guardian and ExecutionerTo examine rhe causes of life, we must fret have recourse to death,Mary Shelley. FfEbook The biology of cancer (2/E): Part 2
o the organism s health and viability.T e apoptotic program that may be activated by p53 is built into rhe control circuitry of most cells throughout Chapter 9p53 and Apoptosis: Master Guardian and ExecutionerTo examine rhe causes of life, we must fret have recourse to death,Mary Shelley. FfEbook The biology of cancer (2/E): Part 2
r cells. In the present case, such antibodies were used to stain human mammary epithelial cells (MECs) that were transformed by introduction of the SVChapter 9p53 and Apoptosis: Master Guardian and ExecutionerTo examine rhe causes of life, we must fret have recourse to death,Mary Shelley. FfEbook The biology of cancer (2/E): Part 2
cams a sure and stable foothold within a tissue. Without a clear description of p53 function and apoptosis, we have no hope of understanding a fundamChapter 9p53 and Apoptosis: Master Guardian and ExecutionerTo examine rhe causes of life, we must fret have recourse to death,Mary Shelley. FfEbook The biology of cancer (2/E): Part 2
by a region of the viral genome that is also expressed when this virus infects and multiplies within monkey kidney cells—host cells that permit a fullChapter 9p53 and Apoptosis: Master Guardian and ExecutionerTo examine rhe causes of life, we must fret have recourse to death,Mary Shelley. FfEbook The biology of cancer (2/E): Part 2
ted an apparent molecular weight of 53 to 54 kilodaltons (Figure 9.2A). Antisera reactive with the p53 protein were found to detect this protein in moChapter 9p53 and Apoptosis: Master Guardian and ExecutionerTo examine rhe causes of life, we must fret have recourse to death,Mary Shelley. FfEbook The biology of cancer (2/E): Part 2
by non-viral mechanisms, such as the F9 embryonal carcinoma cells analyzed in Figure 9.2A. T e latter observations indicated that p53 was of cellularChapter 9p53 and Apoptosis: Master Guardian and ExecutionerTo examine rhe causes of life, we must fret have recourse to death,Mary Shelley. FfEbook The biology of cancer (2/E): Part 2
cify oncoproteins that associate with p53 or per-turb its function (Table 9.1). (As we will discuss later in this chapter, and as is apparent from thiChapter 9p53 and Apoptosis: Master Guardian and ExecutionerTo examine rhe causes of life, we must fret have recourse to death,Mary Shelley. FfEbook The biology of cancer (2/E): Part 2
3T3 mouse fibroblasts (3T3) transformed by SV40, as well as F9 mouse embryonal carcinoma cells, were exposed to 35S-metlx>mne. and resulting cell lysChapter 9p53 and Apoptosis: Master Guardian and ExecutionerTo examine rhe causes of life, we must fret have recourse to death,Mary Shelley. FfEbook The biology of cancer (2/E): Part 2
0 large T (the 94-kD protein) with pS3. but they did show that p53 was a cellular protein that was present in elevated amounts in two types of transfoChapter 9p53 and Apoptosis: Master Guardian and ExecutionerTo examine rhe causes of life, we must fret have recourse to death,Mary Shelley. FfGọi ngay
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