Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases
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Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases
Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Identifying Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases Quantitative Enhancement-Based Imaging Biomarkers In Patients With Colorectal Cancer Liver Metastases Undergoing Loco-Regional Tumor TherapyMansur Abdul GhaniFollow this and additional works at: https://elischolar.library.yale.edu/ymtdlÔ* Part of the Medicine and Health Sciences CommonsRecommended Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases CitationGhani, Mansur Abdul, ‘Identifying Quantitative Enhancement-Based Imaging Biomarkers In Patients With Colorectal Cancer Liver Metastases UndergLuận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases
oing Loco-Regional Tumor Therapy' (2019). Yale Medicine Thesis Digital Library. 3497.https://elischolar.library.yale.edu/ymtdl/3497This Open Access ThYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Identifying Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases been accepted for inclusion in Yale Medicine Thesis Digital Library by an authorized administrator of EhScholar - A Digital Platform for Scholarly Publishing at Yale. For more information, please contact elischoiar@yaie edu.Identifying Quantitative Enhancement-based Imaging Biomarkers in Patients wi Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases thColorectal Cancer Liver Metastases undergoing Loco-regional Tumor TherapyA Thesis Submitted to the Yale University School of Medicine in Partial FulLuận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases
fillment of the Requirements foi the Degree of Doctor of MedicinebyMansur Abdul Ghani2019Identifying Quantitative Enhancement-based Imaging BiomarkersYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Identifying Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases ion of Interventional Radiology. Department of Radiology and Biomedical Imaging. Yale School of Medicine. New Haven. CTlire purpose of tills study was to test and compar e die ability of radiologic measurements of lesion diameter. \ oluiuc. and enhancement on baseline magnetic resonance (MR) images Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases to be predictors of overall survival (OS) and markers of treatment response in patients with liver-dominant colorectal cancer metastases undergoing loLuận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases
co-regional tumor therapies.This retrospective study included 88 patients with colorectal cancer (CRC) liver metastases, treated with Uansaitcrial chcYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Identifying Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases Semi-automated whole liver and tumor segmentations of three dominant lesions were performed on baseline MRĨ to calculate total rumor volume (TTV) and total Ever volumes (TLV). Quantitative 3D analysis was performed to calculate enhancing tumor volume (ETV). enliancing tumor burden (E I B. calculated Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases as ETV/TLV), enhancing liver volume (ELV). and enhancing liver burden (ELR, calculated as ELV. TLV). Overall and enhancing tumor diameters were alsoLuận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases
measured Response assessment was analyzed 111 a subset of 63 patients who received 1 -month MR1 follow-up imaging using RECIST. 111RECIST. change 111 Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Identifying Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases ics. The predictive value of each parameter was assessed by Kaplan-Meier survival curves as well as univariate and multivariate cox proportional hazard models (statistical significance defined as p < .05).In baseline imaging analysis, all methods except ELB achieved statistically significant separat Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases ion of survival curves. Multivariate analysis showed a HR of 2.1 (95% Cl 1.3-3.4./? 0.001) for enhancing tumor diameter. HR 1.7 (95% Cl 1.1-2.s.p 0.01Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases
) for IT V. HR 2.3 (95% Cl L 1-3.9.p 0.001) for ETV. and HR 2.4 (95% Cl 1.1-1.0. p=l).001) for F.TR. Among treatment response assessment methods, onlyYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Identifying Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases ent of CRC liver metastases on baseline MR imaging is strongly associated with patient survival after loco-regional tumor therapy, suggesting that ETV and LIB arc bet lei prognostic indicators than non-cirlranccmcnl based and one-dimensional based markers. However, while volumetric-based methods are Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases superior to ID methods, enhancement-based methods of treatment response assessment were nor successtill in predicting suivival. A potential implicatiLuận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases
on of these findings as novel staging markers warrants prospective validation.AcknowledgementsI greatly appreciate the Yale School of Medicine office Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Identifying Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases chter and Dr. Julius Chapiro for making this thesis possible, and going above and beyond the obligations of good mentors. Under their tutelage and guidance, the Yale Interventional Oncology Research Lab has become another family to me that has fostered all areas of my professional and personal growt Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases h.Thank you to my parents. Shahid Ghani and Arshia Ralunan for theirunconditional love and support I owe any and every success I achieve in my life toLuận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases
your sacrifices. To my brother. Yusuf Ghani, thank you for always reminding me what really matters in life. Finally, to my best friend and beautiful Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Identifying Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases e of ContentsINTRODUCTION....................................................1METHODS.........................................................5RESULTS PART I: BASELINE MR IMAGING ANALYSIS...................15 Luận văn thạc sĩ identifying quantitative enhancement based imaging biomarkers in patients with colorectal cancer liver metastases Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466IdentifyingGọi ngay
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