Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency
Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency
Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Inhibition o Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency of The Akt1-Mtorc1 Axis Alters Venous Remodeling To Improve Arteriovenous Fistula PatencyArash FereydooniFollow this and additional works at: https://elischolar.library.yale.edu/ymtdlRecommended CitationFereydooni, Arash, 'Inhibition Of The Akt1-Mtorc1 Axis Alters Venous Remodeling To Improve Arteri Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency ovenous Fistula Patency’ (2019). Yale Medicine Thesis Digital Library. 3899.https://elischolar.library.yale.edu/ymtdl/3899This Open Access Thesis is bLuận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency
rought to you for free and open access by the School of Medicine at EliScholar - A Digital Platform for Scholarly Publishing at Yale. It has been acceYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Inhibition o Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency at Yale. For more information, please contact elischoiar@yale edu.Inhibition of the Aktl-mTORCl Axis Alters VenousRemodeling to Improve Arteriovenous Fistula PatencyA Thesis Submitted to theYale University School of Medicinein Partial Fulfillment of the Requirements for theDegree of Doctor of Medici Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency ne andMaster of Health SciencesByArash Fereydooni2020AbstractArteriovenous fistulae (AVF) are the most common access created for hemodialysis, but upLuận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency
to 60% do not sustain dialysis within a year, suggesting a need to improve AVF maturation and patency. In a mouse AVF model, Aktl regulates fistula waYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Inhibition o Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency eal injections of raparnycin reduced AVF wall thickness with no change in diameter. Rapamycin decreased smooth muscle cell (SMC) and macrophage proliferation; rapamycin also reduced both Ml and M2 type macrophages. AVF in mice treated with rapamycin had reduced Aktl and mTORCl but not mT0RC2 phospho Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency rylation. Depletion of macrophages with clodronate-containing liposomes was also associated with reduced AVF wall thickness and both Ml- and M2-type mLuận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency
acrophages; however, AVF patency was reduced. Rapamycin was associated with improved long-term patency, enhanced early AVF remodeling and sustained reYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Inhibition o Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency uating the Aktl-mTORCl signaling pathway in SMC and macrophages. Macrophages arc associated with AVF wall thickening and M2-type macrophages may play a mechanistic role in AVF maturation. Rapamycin is a potentialtranslational strategy to improve AVF patency.https://khothuvien.cori!AcknowledgementsI Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency am eternally indebted to my incredible mentor. Professor Alan Dardik, for his constant support and insight; he has served as an inspiring role model aLuận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency
nd showed me what it means to be a successful surgeon-scientist. He has invested in my career and given me opportunities I did not deserve. I am grateYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Inhibition o Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency d.I would like to also thank my clinical mentors, Dr. Cassius Ochoa Chaar and Dr. Naiem Nassiri, for showing me what it means to be excellent academic surgeons, to deliver the best comprehensive care to our patients, and not to be afraid to push the envelope and advance the field of vascular surgery Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency . Drs. Julia Chen, Christine Deyholos, Anand Brahmandam, Robert Botta, Jason Chin and Kristine Orion, I sincerely appreciate your teaching, mentorshipLuận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency
and friendship. Dr. Raul Guzman, thank you for your leadership, support and encouragement.I would like to thank the Howard Hughes Medical Institute, Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Inhibition o Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency udent Research for their support with my research endeavors throughout medical school.Most importantly, my journey to become a surgeon-scientist would not be possible without the sacrifices of my parents, Alireza and Naimeh, who unrooted their lives and immigrated to the United States ten years ago Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency to provide my sisters and mewith better educational opportunities. This work is dedicated to them.Table of Contents1Introduction......................Luận văn thạc sĩ inhibition of the akt1 mtorc1 axis alters venous remodeling to improve arteriovenous fistula patency
...........................................11.1.Poor Clinical Outcomes in Arteriovenous Fistulae utilization........11.2.Mechanisms of Fistula MaturatYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Inhibition oYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466Inhibition oGọi ngay
Chat zalo
Facebook