Luận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein
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Luận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein
Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine 'Ihesis Digital LibrarySchool of Medicine43466Insulin And Luận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein d Non-Insulin Dependent Glut4 Trafficking: Regulation By The Tug ProteinStephen DevriesFollow this and additional works at: https://eljscholar.library.yale.edu/ynitdlRecommended CitationDevries, Stephen, 'Insulin And Non-lnsulin Dependent Glut4 Trafficking: Regulation By The Tug Protein* (2019). Idl Luận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein e AWrcirif IhtHi Digital Ubraọ. Ằ4S9.https://elncholar.library.yale.edU/ymtdl/.Mji9Ihis Open AccessIs brought to you for free and open access by the SLuận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein
chool of Xiedcmc at EhScholar - A Digital Platform for ScholarlyPubliching at Yale. It hai been accepted tor indwion in Yale Medicine them Digital LibYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine 'Ihesis Digital LibrarySchool of Medicine43466Insulin And Luận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein tSyale.edu.Insulin and lion-insulin dependent GLUT4 trafficking:regulation by the TUG proteinA Thesis Submitted tothe Yale University School of Medicinein Partial Fulfillment of the Requirements for theDegree of Doctor of MedicinebyStephen Graham DeVries2019AbstractThe body tightly regulates glucose Luận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein production and disposal despite changing metabolic demands, including large post-prandial and fasting fluctuations. Specifically, under the action ofLuận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein
insulin, muscle contraction, ischemia, and poor nutrient availability, cells increase the amount of the glucose transporter type 4 (GI.UT4) ar rhe plYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine 'Ihesis Digital LibrarySchool of Medicine43466Insulin And Luận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein protein mediates both insulin dependent and insulin independent pathways to increase GLUT4 at the plasma membrane. In mice fed a high far diet to induce insulin resistance, rhe regulation of rhe endoproteolytic cleavage of the TUG protein was disrupted. We also present evidence that helps to identi Luận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein fy the key protease, Usp25m, that cleaves the tethering protein TUG in both an insulin-dependent and insulin-independent manner, releasing GLUT4 fromLuận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein
its storage location in the basal state to the plasma membrane in an activated state. Finally, our results also suggest that in the adipocues and myocYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine 'Ihesis Digital LibrarySchool of Medicine43466Insulin And Luận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein e techniques necessary to work in a cell biology laboratory at the beginning of medical school. His constant guidance and feedback were invaluable to the work that led to this thesis. I would also like to thank Don Li, who helped me adapt and optimize my planned projects. His mentoring both in resea Luận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein rch and in medical training has been a central part of my training as a physician and as a scientist. Finally. I would like to thank my advisor. Dr JoLuận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein
nathan Bogan, whose constant enthusiasm for science, optimism, and support made working in his lab the highlight of my time in medical school.Table ofYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine 'Ihesis Digital LibrarySchool of Medicine43466Insulin And Luận văn thạc sĩ insulin and non insulin dependent glut4 trafficking regulation by the tug protein icking71.4.Thyroid hormone agonists151.5.Exercise-induced glucose uptake in muscle and the role of AMPK161.6.Mouse model of type 2 diabetes mellitus21Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine 'Ihesis Digital LibrarySchool of Medicine43466Insulin AndGọi ngay
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