Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis
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Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis
Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of MedicineJanuary' 2019Neur Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis rodevelopmental Risks Of Non-Syndromic CraniosynostosisRobin T. WilFollow this and additional works at: https://elischolar.library.yale.edu/ymtdlRecommended CitationWu, Robin T„ 'Neurodevetopmental Risks Of Non-Syndromtc Cramoiynostosis' (2019). yWc Afafc'itf Ih&ti Digital Library. S541.httpi://elBc Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis hohr.library.yak.edu/ymtdl/3S41This Open Accctsa. brought to you tor free and open acccu by the School of Medkine at EliScholai - A Digital Platform tLuận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis
or ScholarlyPublishing at Yale. It has been accepted tor indwion in Yale Medicine them Digital Library by an authorized administrator of EliScholar - Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of MedicineJanuary' 2019Neur Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis ic CraniosynostosisA Thesis Submitted io theYale University School of MedicineIn Partial Fulfillment of the Requirements for theDegree of Doctor of MedicineByRobin T. Wu20190Neurodevelopmental Risks of Non-syndromic CraniosynostosisRobin T. Wu, Kyle s. Gabrick, Andrew T. Timberlake, Anusha Singh, Pa Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis ul F. Abraham, James Nic, Taylor Halligan, Raysa Cabrejo, Derek M. Steinbacher, Michael Alperovich, John A. Persing, Yale University, School of MediciLuận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis
ne, New I laven, CT.Purpose: Nonsyndromic craniosynostosis may manifest with complex cognitive, language, behavioral, and emotional sequelae, dependinYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of MedicineJanuary' 2019Neur Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis ds of assessment, sue h as the Bayley St ales of Infant Development (BSID), may not predictive of long-term development, paving the way for newer assessments such as functional magnetic resonance imaging (fMRI) and the event related potentials (ERP), which measures passive neurological responses to Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis speech sounds.Methods: Cranially-malure, post-operative unilateral coronal, metopic, midline SMAD6 mutated and age/race/gender/synostosis/operalion maLuận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis
tched non-SMAD6 controls from the Yale Craniofacial Clinic and the Children's Hospital of Philadelphia (CHOP) completed a double-blinded neurodevelopmYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of MedicineJanuary' 2019Neur Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis eral coronal (ULC) or metopic synostosis were agc/gendcr/handedness matched to controls and participated in a GoNoGo task under fMRI. Craniosynostosis infants were given the BS1D and ERP testing at two points (pre and post operatively), and after they reached >6 years of age, patients completed the Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis Wechsler Abbreviated Scale of Intelligence and Wechsler Fundamentals to measure 5 language functional domains.Results: UI.C patients had a ninni verbaLuận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis
l IQ of 117.3 and performance IQ of 106.4, performed above average on academic achievements except for numerical, but below average on all visual-motoYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of MedicineJanuary' 2019Neur Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis ndocranial biiron lai angle <124) performed belter in word reading (p 0.035) and reading composite (p 0.014) than patients with severe stenosis (>124). After controlling for exogenous factors, midline synostosis patients with SMAD6 mutations performed worse on numerical operations(p=0.046), performa Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis nce IQ(p=0.018), full lQ(p=0.010), and motor coordination(p=0.043) than those without the mutation. Among seven Ul.c and six metopic patients that parLuận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis
ticipated in fMRI, metopic patients had decreased bkxxi-oxygenation-level-dependent signal in the posterior cingulate(p=O.OI7) and middlehttps://khothYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of MedicineJanuary' 2019Neur Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis ed signal in the cuneus(p=().OO9) and ccrebellum(p=0.(X)9). Among 10 craniosynostoses patients who received ERP/BSID testing in infancy followed by school-age neurocognitive testin. the left frontal ER1’ cluster strongly correlated with word reading (R 0.713, p=0.031), reading comprehension (R 0.745 Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis , p=0.021), and language composite scores (R=0.771, p=0.015). Correlations for BS1D cognitive, expressive language, and language composite scores hadLuận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis
no predictive value (R<0.5, p>0.05) for neurocognitive scores.Conclusions: Post-operative cranially mature LLC patients have higher verbal IQ scores, Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of MedicineJanuary' 2019Neur Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis gy in metopic synostosis significantly impacts long-term cognitive function and academic achievement. Neuropsychiatric development may be in whole or in part under genetic control. SMAD6 mutations led to poorer performance on mathematics, performance-IQ, full-IQ, and motor coordination, even after c Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis ontrolling for exogenous factors. LLC patients may have emotional dyregulation in response to frustration while metopic patients may have attenuated eLuận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis
motional reactions. ERP assessment in nonsyndrom ic craniosynostosis patients has significantly better predictive value for future neurocognitive asseYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of MedicineJanuary' 2019Neur Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis d like to thank my co-authors tor their tireless contributions to this work and my faculty mentors for their belief in me. I am so lucky to have gotten the chance to participate in research with Dr. John Persing on work for which he has pioneered and changed the field of craniosynostosis.1 am gratef Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis ul for my wonderful friends and future colleagues in medical school Alyssa Zupon, Rebecca Fine, Elliot Morse, Matthew Swallow, Tejas Sathc, and BrandoLuận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis
n Sumpio, for surviving all the long rotations and late nights with me.A very special thank you to Pranavi Vemuri, Yohan Perera, Jessica Shepis, and JYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of MedicineJanuary' 2019Neur Luận văn thạc sĩ neurodevelopmental risks of non syndromic craniosynostosis leted with monetary contributions from the Plastic Surgery Foundation (Award Number: 513938).Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of MedicineJanuary' 2019NeurGọi ngay
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