Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine
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Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine
Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Medial P Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of KetamineAlexandra ThomasFollow this and additional works at: https://elischolar.library.yale.edu/ymtdlÔ* Part of the Medicine and Health Sciences CommonsRecommended CitationThomas. Alexandra. 'The Medial Prefrontal Cortex To D Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine orsal Raphe Circuit In The Antidepressant Action Of Ketamine’ (2019). Yale Medicine Thesis Digital Library. 3538.https://elischolar.library.yale.edu/yLuận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine
mtdl/3538This Open Access Thesis is brought to you for free and open access by the School of Medicine at EliScholar - A Digital Platform for ScholarlyYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Medial P Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine tal Platform for Scholarly Publishing at Yale. For more information, please contact elischolar@yaie edu.The Medial Prefrontal Cortex to Dorsal Raphe Circuit in theAntidepressant .Action of KetamineA Thesis Submitted to theYale University School of Medicinein Partial Fulfilment of the Requirements fo Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine r theDegree of Doctor of MedicineByAlexandra Moran ThomasDissertation Director: Ronald s. Duman. PhD.43586https://khothuvien.cori!ABSTRACTMajor depresLuận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine
sive disorder is a common and debilitating illness for which there is a notable lack of efficient, effective treatment. While currently available pharYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Medial P Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine r anlagimist ketamine lias show II a much more favorable effect i ver less profile, including improvements in symptoms within hours of administration, even tor many patients who do not respond to typical antidepressants. Ketamine, as a modulator of glutamate signaling ill the brain, has a distinct m Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine echanism of action from the serotonin and norepinephrine modulators that arc currently the mainstay of depression treatment. This dissertation seeks tLuận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine
o contribute to the understanding of this unique mechanism, and particularly the brain circuits affected. Rodent studies have shown that ketamine induYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Medial P Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine targets of this glutainatrrgic activity that are relevant to the ketamine antidepressant effect are unclear, but recent research has suggested a role for the dorsal raphe nucleus DR.\ . which contains most of the brain’s serolomn-prodiicmg cells. In this thesis, I first provide a synthesis of the li Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine terature on the mechanism of ketamine’s antidepressant effect and the neural circuits that might underlie it. 1 then investigate the projection from tLuận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine
he mPl'C to the DRN using oplogenelic stimulation of mPFC-original'mgaxon terminals ill tile DRX, rinding dial activation Ilf this pathway produces anYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Medial P Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine of depression-like Ijehavior. I also perform immunohistochemical studies of the DRN. which indicate that both serotonergic and non-scrotonergic cells areiihttps://khothuvien.cori!activated by this stimulation. I then find additional support for this behavioral selectivityusing a pharmacological app Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine roach: by inhibiting serotonin release during ketamine administration. I find that DRN activity is needed for the antidepressant effect of ketamine onLuận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine
the FST but not on other behavioral tests. Finally, I interrogate the projection from the mPFC to the nucleus accumbens using the same optogenctic apYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Medial P Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine sion-like behavior and supports a role for serotonin signaling in the behavior measured by the FST.iiihttps://khothuvien.cori!© Alexandra Moran ThomasAll rights reserved.TABLE OF CONTENTSACKNOWLEDGEMENTS..............................................................viLIST OF FIGURES.................. Luận văn Thạc sĩ The Medial Prefrontal Cortex To Dorsal Raphe Circuit In The Antidepressant Action Of Ketamine ...........................................viiiYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Medial PYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Medial PGọi ngay
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