Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers
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Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers
Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Role OfT Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck CancersTejas Sudarshan SatheFollow this and additional works at: https://elischolar.library.yale.edu/ymtdlRecommended CitationSathe, Te|as Sudarshan. ‘The Role Of Trail .And Cyid Muunonin Tie Etiology Of Human Papill Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers omavirus Driven Head -And Neck Cancers' (2019). Yak MtdKine Twsii Digital Library. 3S3O.https://eliwholar.library.yak.edu/ymtdl/3S30Ihic Open Acceti ĩLuận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers
heds a brought to you for free and open access by the School of .Medxtnc at EhSchobr - A Digital Platform for Scholarly Publishing at Yale. It hai beeYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Role OfT Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers ingat Yale. For more information, pie ace contact eli«cholariSyale.edu.https: //khoth uvien .comThe Role of TRAF3 and CYLD Mutation in the Etiology of Human Papillomavirus Driven Head and Neck CancersA THESIS SUBMITTED TO THEYale University School of MedicineIN PARTIAL FULFILLMENT FOR THEDEGREE OF D Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers octor of MedicineTejas s. SatheAdvisors: Wendell G. Yarbrough. MD. MMHC, FACS A Natalia Issaeva. PhDThesis Committee Members: Wendell G. Yarbrough, MDLuận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers
, MMHC, FACS, Natalia Issaeva, PhD, a Karen Anderson, PhD43586t* Copyright by Tejas s. Sathe. 2019. All rights reserved.AbstractThe incidence of HPV-pYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Role OfT Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers f these tumors recur or metastasize despite aggressive therapy. Currently, there are no biomarkers that can identify HPV-positive HNSCC patients who would benefit from reduced doses of radiation-which when given at full dose carries significant morbidity. Through analysis of a limited cohort of The Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers Cancer Genome Atlas (TCGA), we previously showed that two genes, TRAF3 and CYLD, were frequently deleted or mutated in HPV-positive HNSCC. TRAF3 and CLuận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers
YLD are functionally related negative regulators of the transcription factor NF-xB. In HNSCC. TRAF3 and CYLĐ mutations were correlated with increased Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Role OfT Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers novel pathway of carcinogenesis dependent on dysregulation of NF-xB pathway intermediates such as TRAF3 or CYLD.Survival analysis based on TRAF3/CYLD status was expanded to the entire TCGA HNSCC cohort. CYLD knockdown was achieved in vitro using CRISPR/Casọ. Western Blotting and a luciferase report Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers er assay were used to confirm CYLD depletion and NF-xB activation, respectively. Parental or CYLD-depletcd cells were then transfected with HPV DNA anLuận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers
d HPV replication was determined using qRT-PCR. Finally, long control region (LCR) transcriptional activity was assessed in parental or CYLD-deplctcd Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Role OfT Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers 2b% of HPV-positivc HNSCC. Patients with HPV-positive tumors harboring TRAF3/CYLD mutations demonstrated markedly improved survival over patients with HPV-positive tumors without mutations or with HPV-negative tumors. CYLD knockdown in cultured cells resulted in constitutive activation of NF-xB in Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers vitro. Preliminary data suggested that activation of NF-xB increased HPV replication and activity at the LCR.Together, our data define a previously unLuận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers
recognized subset of HPV-positive HNSCC that may rely on constitutively active NF-xB. Furthermore, mutations in TRAF3 and CYLD may serve as biomarkersYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Role OfT Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers h CYLD depletion. This model will be useful to further investigate mechanisms of HPV-driven carcinogenesis in the head and neck.iiiContentsAbstractiiiIntroductionIMethods20Results26Discussion40 Luận văn Thạc sĩ The Role Of Traf3 And Cyld Mutationin The Etiology Of Human Papillomavirus Driven Head And Neck Cancers Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Role OfTGọi ngay
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