Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association
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Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association
Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Worsenin Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association ng Trajectory 01 Social Impairment In Preterm Born Young Adults And Its Association With Altered Amygdalar Functional ConnectivityChristina JohnsFollow this and additional works at: https://elischolar.library.yale.edu/ymtdlRecommended CitationJohns, Christina, ■ The Worsening Trajectory Of Social Im Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association pairment In Preterm Born Young Adults And Its Association With Altered Amygdalar Functional Connectivity" (2019). Yak Mtdicini ntesis DigrhtJ Library.Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association
3506.https://elischolar.library.yale.edu/ymtdl/3506Ihl* Open Access lh»is a brought to you tor free and open access by the School of Xiedcinc at EhScYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Worsenin Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association administrator of EliSchobr - A Digital Platform for Scholarly Publishing at Yale. For more information, pkase contact eliwholirtSyile.edu.The worsening trajectory of social impairment in preterm born young adults and its association with altered amygdalar functional connectivity'A Thesis Submitted t Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association o the Yale University School of Medicine in Partial Fulfillment of the Requirements for the Degree of Doctor of MedicinebyChristina B. Johns2019THE WOLuận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association
RSENING TRAJECTORY OF SOCIAL IMPAIRMENT IN PRE TERM BORN YOUNG ADULTS AND ITS ASSOCIATION WITH ALTERED AMYGDALAR FUNCTIONAL CONNECTIVITYChristina B. JYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Worsenin Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association C l. USA, :l>eparlinent of Radiology and Biomedical Imaging. Yale University School of Medicine. New Haven. CT. USA. -’Department of Pediatrics. Warren Alpcn Medical School of Brown University-. Providence. RI. USA and -“Department OỈNeurology. Yale University School of Medicine. New Haven. CT. USA. Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association Survivors of preterm birth experience long-lasting behavioral problems characterized by increased risk of depression, anxiety, and impaired social funLuận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association
ctioning. 1 he amygdala is a key region for social functioning, and alterations in amygdalar structure and connectivity are thought to underlie socialYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Worsenin Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association tional connectivity of the amygdala arc not well-studied hl former preterm born individuals (PTs).It was hypothesized that PTs would show impaired social functioning compared to term controls beginning in early childhood and continuing to young adulthood. It was also hypothesized that amygdala resti Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association ng stale functional connectivity is altered in PT bom young adults, and that alterations in amygdala functional connectivity would mediate increased iLuận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association
nternalizing behavior and socialization problems in PT born young adults.In a group of former very PT infants (600 to 1250 grams birth weight) and matYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Worsenin Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association and 16. the Youth Self Report administered at age 16. and the Vineland Adaptive Behavior Scales (VABS) administered at ages 8 and 18. Amygdalar functional connectivity was examined using resting-state functional magnetic resonance imaging at age 20.By parent report, preterm-bom children and adolesce Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association nts exhibit behaviors demonstrating increased social impairment compared to their term-bora peers, starting at school-age and becoming more prominentLuận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association
by young adulthood. P l demonstrate a worsening trajectory in CBCI. Withdrawn scores from school-age to young adulthood compared to T (group*time inteYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Worsenin Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association thermore, amygdalar connectivity is altered in the formerly prematurely-born, and markers of social impairment correlate negatively with altered amygdala-posterior cingulate cortex connectivity (Social competence r—0.37. p-0.03; socialization r—0.42, p-0.01).As this cohort of PTs does not include in Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association dividuals who suffered any form of neurologic injury, their parent-reported increase in behavioral markers of social impairment may be attributable toLuận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association
prematurity rather than to neurologic injury. Moreover, these data suggest that previously established social impairments in PT as compared to T worsYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Worsenin Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association d by prematurely-bom individuals.https://khothuvien.cori!AcknowledgementsI thank Dr. Laura Ment for her guidance and encouragement over the last four years. She has taught me much about preterm neurodevelopment, research design, and balancing a research and clinical career and I'm very grateful for Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association her mentorship.I also thank Dr. Dustin Scheinost for his ideas and guidance which were central to the completion of this work and for his assistance iLuận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association
n writing up the original manuscript.Thank you to Dr. Betty Vohr for her insights during the completion of this analysis and to Cheryl Lacadie for herYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The Worsenin Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association s. Deborah Hirtz and Walter Allan for their scientific expertise; Marjorene Ainley for the follow-up coordination; Jill Maller-Kesselman. Susan Delaney and Victoria Watson for their neurodevelopmental testing; Hedy Sarofin and Terry-Hickey for their technical assistance.Finally. I thank the children Luận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association and their families for their participation in the study.This work was supported by NIH NS27116 and by the Vernon w. Lippard MD Student Summer ResearcLuận văn Thạc sĩ The Worsening Trajectory Of Social Impairment In Preterm Born Young Adults And Its Association
h Fellowship.Table of ContentsTable of Frequently Used Abbreviations..........................................1Introduction...........................Yale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The WorseninYale UniversityEliScholar - A Digital Platform for Scholarly Publishing at YaleYale Medicine Thesis Digital LibrarySchool of Medicine43466The WorseninGọi ngay
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