WO2005030167A2

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WO2005030167A2

<121 INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)(19) World Intellectual Property Organization International Bureau(4

WO2005030167A2 43) International Publication Date 7 April 2005 (07.04.2005)PCT(10) International Publication Number WO 2005/030167 A2wo 2005/030167 A2 I mil II Illi

II mill mil IIIII IIII Illi I mil Hill IIIII IIIIIIIIIIIMIIIIIIIIIIIIIIIIIII(51) International Patent Clasdfkatlon7:A6IK 9'00-21International Applicat WO2005030167A2

ion Number:KT/US2004A)31797-22International Eiling Date:27 September 2004 (27.09.2004)-25Filing Language:English-26Publication language:English(30) Pr

WO2005030167A2

iority Data:10/671,72029 September 2003 (29.09.200.3) 1 IS-71Applicant (for all designated States except US): NO-VADEL PHARMA INC. |US/US|; 25 Minneak

<121 INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)(19) World Intellectual Property Organization International Bureau(4

WO2005030167A2 lemington. NJ 08822 (US). ABD EI^SHAFY, Mohammed |US/US|: 428 Townline Road, Hauppauge, NY 11788 (US).(74) Agents: PO1SSANT. Brian, M.Ct al.; Jones Da

y, 222 East 41 st Street. New Yoti. NY 10017-6702 (US).(81) Designated States (unless otherwise indicated, for every kind of national protection avail WO2005030167A2

able): AIÌ. AG. AK AM, AT. AU. AZ. BA. BB. BG. BR. BW. BY. B7, CA. CH. CN. CO. CR. cu. cz. DE, DK. DM. DZ. EC, EE. EG. ES. Fl. GB. GD. GE. GIL GM. HR.

WO2005030167A2

HU. ID. IL. IN. IS. JP. KE. KG. KP. KR. KZ. ir. l.K. LR. kS. LT, LU. LV. MA. MD, MG. MK. MN. MW. MX. MZ. NA. Nl. NO. NZ. OM. PG, PH. PL. PT, RO. RU.S

<121 INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)(19) World Intellectual Property Organization International Bureau(4

WO2005030167A2 every kind of regional proiet tion available): ARIK) (BW, Gll, GM. KE. 1-S. MW. M7, NA. SD. SL. sz. rz. UG. ZM./Continued on next page/(54) Title: BUC

CAL POLAR AND NON-POLAR SPRAY CONTAINING ALPRAZOLAM(57) Abstract: Buccal aerosol spraysor capsules using polar and non-polar solvents have now been de WO2005030167A2

veloped which provide alprazolam for rapid absorption through the oral mucosa. resulting in fast onset of effect. The buccal polar compositions of the

WO2005030167A2

invention comprise formulation (I): aqueous polar solvent, alprazolam, and optional flavoring agent; formulation (ID: aqueous polar solvent, alprazol

<121 INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)(19) World Intellectual Property Organization International Bureau(4

WO2005030167A2 polar solvent, alprazolam, optional flavoring agent, and propellant; formulation (V): a mixture of a polar solvent and a non-polar solvent, alprazolam

, and optional flavoring agent; formulation (VI): a mixture of a polar solvent and a non polar solvent, alprazolam, optional flavoring agent, and prop WO2005030167A2

ellant.WO 2005/030167 A2III11 Illi I lllll mull llllllllllllllll[llllllllllll mil 11 Illi Illizwx Eurasian (AM. AZ. BY, KG, KZ. MD. RƯ, TJ. TMx Europe

WO2005030167A2

an (AT, BE. BO. CH. CY. cz. DE. DK. EE, ES. FI. JR, GB. GR. HU. IE. 1T, LU. MC. NL. PL. PT, RO, SE, SI. SK. TRỊ, OAPl (Bl. Bl, Cl', CG. Cl. CM. GA. GN

<121 INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)(19) World Intellectual Property Organization International Bureau(4

WO2005030167A2 codes and other abbreviations, refer to the ‘Guidance Notes on Codes and Abbreviations ‘ appearing at the beginning of each regular issue of the per G

azette.wo 2Ơ05/030167PCT/11S2004/031797BUCCAL, POLAR ANDNON-POL AR SPRAY CONTAININGALPRAZOLAMCROSS REFERENCE TO RELATED APPLICATIONS[0001J This applic WO2005030167A2

ation is a continuation-in-part of application no. 10/230,060, filed August 29,2002, pending, which is a continuation-in-part of application no. 09/53

WO2005030167A2

7,118, filed March 29,2000 which is a continuation-in-part of the U.S. national phase designation of PCT/US97/17899 filed October 1, 1997, the disclos

<121 INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)(19) World Intellectual Property Organization International Bureau(4