Development and evaluation of personalized risk assessments for osteoporotic patients
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: Development and evaluation of personalized risk assessments for osteoporotic patients
Development and evaluation of personalized risk assessments for osteoporotic patients
DEVELOPMENT AND EVALUATION OF PERSONALIZED RISK ASSESSMENTS FOR OSTEOPOROTIC PATIENTSbyLe Phuong Thao HoA thesis submitted to the University of Techno Development and evaluation of personalized risk assessments for osteoporotic patients ology Sydney in partial fulfilment of the requirements for the Degree of Doctor of PhilosophySchool of Biomedical Engineering.Faculty of Engineering and Information Technology, University of Technology SydneyAustralia2018CERTIFICATE OF ORIGINAL AUTHORSHIP1Lc Phuong rhao HO. declare that this thesis Development and evaluation of personalized risk assessments for osteoporotic patients is submitted in fulfilment of the requirements for the award of Doctor of Philosophy hi the School of Biomedical Engineering at the University of TechDevelopment and evaluation of personalized risk assessments for osteoporotic patients
nology Sydney.Ĩ also declare that the intellectual content in this thesis is the product of my own work, except to the extent that assistance from othDEVELOPMENT AND EVALUATION OF PERSONALIZED RISK ASSESSMENTS FOR OSTEOPOROTIC PATIENTSbyLe Phuong Thao HoA thesis submitted to the University of Techno Development and evaluation of personalized risk assessments for osteoporotic patients ion sources and literature used are indicated in the thesis.The work in this thesis has not previously been submitted for a degree, nor has it been submitted as part of the requirements of a degree, at any other academic institution, except as fully acknowledged within the text.This research is supp Development and evaluation of personalized risk assessments for osteoporotic patients orted by the Australian Government Research Training Program.Signature of Candidature:Date: 6 October 2018ABSTRACTOsteoporosis is a skeletal disease cDevelopment and evaluation of personalized risk assessments for osteoporotic patients
haracterized by reduced bone strength and deterioration in bone microstructure, leading to increased risk of fragility fracture. Bone strength is mainDEVELOPMENT AND EVALUATION OF PERSONALIZED RISK ASSESSMENTS FOR OSTEOPOROTIC PATIENTSbyLe Phuong Thao HoA thesis submitted to the University of Techno Development and evaluation of personalized risk assessments for osteoporotic patients ned by the individual's genetic structure and environmental exposures. While several genetic variants associated with BMD have been identified, the contribution of these variants to fracture risk prediction has not been well-documented. In this thesis, I sought to (i) construct an osteogenomic profi Development and evaluation of personalized risk assessments for osteoporotic patients le from BMD-associated genetic variants; (ii) assess the association between the profile and fracture risk and bone loss: (iii) determine the clinicalDevelopment and evaluation of personalized risk assessments for osteoporotic patients
utility of the osteogenomic profile in terms of fracture risk assessment; and (iv) improve the accuracy of hip fracture prediction in postmenopausal DEVELOPMENT AND EVALUATION OF PERSONALIZED RISK ASSESSMENTS FOR OSTEOPOROTIC PATIENTSbyLe Phuong Thao HoA thesis submitted to the University of Techno Development and evaluation of personalized risk assessments for osteoporotic patients a population-based longitudinal prospective cohort investigation that involved more than 4000 men and women aged 60+years. The individuals had been followed up to 27 years. The incidence of fracture was ascertained during the follow-up period. A unique osteogenomic profile was constructed for each Development and evaluation of personalized risk assessments for osteoporotic patients individual from 68 BMD-associated genetic variants. The osteogenomic profile was significantly associated with BMD. fracture risk, and BMD changes. InDevelopment and evaluation of personalized risk assessments for osteoporotic patients
corporating the osteogenomic profile into existing prognostic iimodel improved the prognostic performance over and above of traditional clinical risk DEVELOPMENT AND EVALUATION OF PERSONALIZED RISK ASSESSMENTS FOR OSTEOPOROTIC PATIENTSbyLe Phuong Thao HoA thesis submitted to the University of Techno Development and evaluation of personalized risk assessments for osteoporotic patients ogcnomic profile was 71.1%, an increase of 0.5% compared with the model without the profile. More importantly, reclassification analysis showed that compared with the clinical risk factor (CRT) model, adding GRS resulted in 16% of individuals moving correctly from one risk category to another. In de Development and evaluation of personalized risk assessments for osteoporotic patients cision curve analysis, 1 found that for risk threshold greater than 15%, the ostcogenomic profile could help reduce the number of unnecessary treatmenDevelopment and evaluation of personalized risk assessments for osteoporotic patients
ts. I also demonstrated that the predictive accuracy of fracture prediction using artificial neural network model was improved to 87% (AUC 0.94), whicDEVELOPMENT AND EVALUATION OF PERSONALIZED RISK ASSESSMENTS FOR OSTEOPOROTIC PATIENTSbyLe Phuong Thao HoA thesis submitted to the University of Techno Development and evaluation of personalized risk assessments for osteoporotic patients conclusion, this thesis shows that an osteogenomic profile constructed from multiple BMD associated genetic variants is associated with fracture risk, and that the incorporation of osteogenomic profile could enhance the accuracy of fracture risk assessment for an individual men and women.iiiPUBLICA Development and evaluation of personalized risk assessments for osteoporotic patients TIONS ARISING FROM THIS THESISPublished Papers1Mai. H. T.. Tran. T. s.. Ho-Le, T. p.. Pham. T. T., Center. J. R.. Eisman. J. A.. & Nguyen. T. V. (2018Development and evaluation of personalized risk assessments for osteoporotic patients
). Low-trauma rib fracture in the elderly: Risk factors and mortality consequence. Bone. 116. 295-300. doi:10.1016.j.bone.2018.08.0162Ho-Le, T. p., PhDEVELOPMENT AND EVALUATION OF PERSONALIZED RISK ASSESSMENTS FOR OSTEOPOROTIC PATIENTSbyLe Phuong Thao HoA thesis submitted to the University of Techno Development and evaluation of personalized risk assessments for osteoporotic patients tion of "osteogenomic profile". Arch Osteoporos. 13(1). 68. doi: 10.1007/s 11657-018-0480-23Ho-Pham, L. T., Ho-Le. T. p. Mai. L. D-, Do. T. M., Doan. M. c.. & Nguyen. T. V. (2018). Sex-difference in bone architecture and bone fragility in Vietnamese. Sci Rep. 8(1), 7707. doi:10.1038/s41598-018-26053 Development and evaluation of personalized risk assessments for osteoporotic patients -94Ho-Le, T. p.. & Nguyen, T. V. (2018). Mathematics Research in Association of Southeast Asian Nations Countries: J Scientometric Analysis of PatternDevelopment and evaluation of personalized risk assessments for osteoporotic patients
s and Impacts. Frontiers in Research Metrics and Analytics. 3(3). doi: 10.3389. frma.2018.000035Ho-Le TP. Center JR. Eisman JA. Nguyen HT. Nguyen TV. DEVELOPMENT AND EVALUATION OF PERSONALIZED RISK ASSESSMENTS FOR OSTEOPOROTIC PATIENTSbyLe Phuong Thao HoA thesis submitted to the University of Techno Development and evaluation of personalized risk assessments for osteoporotic patients ring in Medicine and Biology Society (EMBC). 11-15 July 2017; 10.1109. EMBC.2017.80377846Nguyen TV, Ho-Le TP. Le ƯV. International collaboration in scientific research in Vietnam: an analysis of patterns and impact. Scientometrics. journal article. Feb 2017; 110(2): 1035-51.7Ho-Le TP. Center JR, Eis Development and evaluation of personalized risk assessments for osteoporotic patients man JA. Nguyen HT. Nguyen TV. Prediction of Bone .Mineral Density and Fragility Fracture by Genetic Profiling. Journal of Bone and Mineral Research. FDevelopment and evaluation of personalized risk assessments for osteoporotic patients
eb 2017;32(2):285-93.8Pham HM. Nguyen sc. Ho-Le TP, Center JR. Eisnian JA, Nguyen TV. Association of .Muscle Weakness With Post-Fracture Mortality in DEVELOPMENT AND EVALUATION OF PERSONALIZED RISK ASSESSMENTS FOR OSTEOPOROTIC PATIENTSbyLe Phuong Thao HoA thesis submitted to the University of Techno Development and evaluation of personalized risk assessments for osteoporotic patients ationDEVELOPMENT AND EVALUATION OF PERSONALIZED RISK ASSESSMENTS FOR OSTEOPOROTIC PATIENTSbyLe Phuong Thao HoA thesis submitted to the University of TechnoGọi ngay
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