Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase
Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase
Pressurized Carbon Dioxide in Biocatalysis:Enhanced Catalytic Activity of LipaseThesis submitted for the degree ofDoctor of EngineeringbyHoang Nam Hai Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase iMatsuda Laboratory Department of BioengineeringGraduate School of Bioscience and Biotechnology Tokyo Institute of TechnologyYokohama, July 2018AbstractAbstractSolvents, which play an important role in chemical and pharmaceutical industries, have often been claimed as a major source of waste generat Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase ion and associated environmental and economic burdens. With the eco-environmental urge of developing sustainable processes, academic and industrial inPressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase
tentions have been focused both on minimizing the overall solvent usage and on replacing traditional organic solvents by more environmentally friendlyPressurized Carbon Dioxide in Biocatalysis:Enhanced Catalytic Activity of LipaseThesis submitted for the degree ofDoctor of EngineeringbyHoang Nam Hai Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase in organic solvents as well as in 'green' anhydrous media, such as ionic liquids and supercritical fluids. Carbon dioxide, which has a number of positive impacts on green chemistry as a nonflammable, nontoxic, abundant, and generally chemically inert source, has been intensively studied in its supe Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase rcritical phase as an attractive solvent for enzymatic reactions due to its greenness, low viscosity, high diffusivity, and ease of recovery of the rePressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase
action products. However, supercritical co? remains drawbacks that hinders its utilization in many industrial applications, given its high pressure opPressurized Carbon Dioxide in Biocatalysis:Enhanced Catalytic Activity of LipaseThesis submitted for the degree ofDoctor of EngineeringbyHoang Nam Hai Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase nded bio-based liquids for biocatalysis. In particular, lipase-catalysed reactions resulted in significantly increased activity and broaden substrate specificity to bulkier substrates. In addition, by taking advantage of this in situ solvent tunability, the lipase activity was successfully modulated Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase for organic synthesis of wide range chiral compounds. The molecular dynamics simulation revealed novel changes in the lipase structure that the enzymPressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase
e became more tolerant to wider range of bulky substrates in pressurized CO;.Keywords: Lipase-catalysed transesterification, Kinetic resolution, SubstPressurized Carbon Dioxide in Biocatalysis:Enhanced Catalytic Activity of LipaseThesis submitted for the degree ofDoctor of EngineeringbyHoang Nam Hai Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase ntAbstract...........................................................................iTable of content..................................................................iiAcknowledgements..................................................................viDeclaration................................... Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase ...................................viiList of abbreviations.............................................................xiList of figures.............Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase
.....................................................xiiList of tables...................................................................xiv1IntroductPressurized Carbon Dioxide in Biocatalysis:Enhanced Catalytic Activity of LipaseThesis submitted for the degree ofDoctor of EngineeringbyHoang Nam Hai Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase solution.........................................................................11.1.1Enzymes as biocatalysts for organic synthesis.........................11.1.2Biocatalysis in non-aqueous solvents..................................21.1.3Lipase catalysis in enantioselective synthesis............... Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase .........41.1.4Structure and catalytic mechanism of Candida antarcticalipase B......71.1.5Substrate selectivity and chiral recognition by Candida antaPressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase
rctica lipase B.... 81.2Pressurized carbon dioxide as reaction solvents..........................101.2.1Supercritical and liquid CƠ2..................Pressurized Carbon Dioxide in Biocatalysis:Enhanced Catalytic Activity of LipaseThesis submitted for the degree ofDoctor of EngineeringbyHoang Nam Hai Pressurized carbon dioxide in biocatalysis enhanced catalytic activity of lipase s to promote sustainable chemistry:Pressurized Carbon Dioxide in Biocatalysis:Enhanced Catalytic Activity of LipaseThesis submitted for the degree ofDoctor of EngineeringbyHoang Nam HaiGọi ngay
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