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Nội dung chi tiết: Development of an Evidence-Based Nursing Orientation Program for

Development of an Evidence-Based Nursing Orientation Program for

^IlfWestVirginiaUniversityTHE RESEARCH REPOSITORY @ wvuGraduate Theses, Dissertations, and Problem Reports2013Development of a Synthetic Pathway Towar

Development of an Evidence-Based Nursing Orientation Program forrd a Bowl-Shaped c27H12 Polycyclic Aromatic HydrocarbonYang-Sheng SunWest Virginia UniversityFollow this and additional works at: https://researchrepo

sitorywvu.edu/etdRecommended CitationSun, Yang-Sheng, "Development of a Synthetic Pathway Toward a Bowl-Shaped c 27H12 Polycyclic Aromatic Hydrocarbon Development of an Evidence-Based Nursing Orientation Program for

' (2013). Graduate Theses, Dissertations, and Problem Reports. 5004.https://researchrepository.wvu.edu/etd/5004This Thesis is protected by copyright a

Development of an Evidence-Based Nursing Orientation Program for

nd/or related rights. It has been brought to you by the The Research Repository © wvu with permission from the rights-hoider(s). You are free to use t

^IlfWestVirginiaUniversityTHE RESEARCH REPOSITORY @ wvuGraduate Theses, Dissertations, and Problem Reports2013Development of a Synthetic Pathway Towar

Development of an Evidence-Based Nursing Orientation Program forssion from the rights-holder(s) directly, unless additional rights are indicated by a Creative Commons license in the record and/ or on the work itsel

f. This Thesis has been accepted for inclusion in wvu Graduate Theses, Dissertations, and Problem Reports collection by an authorized administrator of Development of an Evidence-Based Nursing Orientation Program for

The Research Repository @ wvu. For more information, please contact researchrepository@mail wvu edu.Development of a Synthetic Pathway Toward a Bowl-

Development of an Evidence-Based Nursing Orientation Program for

Shaped C27H12 Polycyclic Aromatic HydrocarbonYang-Sheng SunThesis submitted to the Eberly College of Arts and Sciences at West Virginia University in

^IlfWestVirginiaUniversityTHE RESEARCH REPOSITORY @ wvuGraduate Theses, Dissertations, and Problem Reports2013Development of a Synthetic Pathway Towar

Development of an Evidence-Based Nursing Orientation Program for Soderberg, Ph. D.Department of ChemistryMorgantown, West Virginia 2013Keywords: Enyne-Allene, Schmittel Cyclization, Buckybowl Copyright 2013 Yang-Sh

eng SunABSTRACTDevelopment of a Synthetic Pathway Toward a Bowl-Shaped C27H12 Polycyclic Aromatic HydrocarbonYang-Sheng SunBowl-shaped and basket-shap Development of an Evidence-Based Nursing Orientation Program for

ed polycyclic aromatic hydrocarbons (PAHs) have attracted considerable attention in recent years. They are challenging targets for total synthesis due

Development of an Evidence-Based Nursing Orientation Program for

to the presence of substantial strain energy in the curved structures. A solution-phase synthesis of a bowl-shaped polycyclic aromatic hydrocarbon C2

^IlfWestVirginiaUniversityTHE RESEARCH REPOSITORY @ wvuGraduate Theses, Dissertations, and Problem Reports2013Development of a Synthetic Pathway Towar

Development of an Evidence-Based Nursing Orientation Program forhe mild reaction conditions provide efficient and flexible designs for bowlshaped and basked-shaped PAHs and their precursors. Our proposed synthesis

strategy for the bowl-shaped C27H12 involves an initial synthesis of a bcnzannulatcd enediynyl propargylic alcohols followed by the cascade cyclizatio Development of an Evidence-Based Nursing Orientation Program for

n reactions of the resulting enync-allcnes. The use of the palladium-catalyzed intramoleular arylation reactions is proposed as a key step leading to

Development of an Evidence-Based Nursing Orientation Program for

the final products. Specifically, transformation of 1-indanone to a key intermediate, 2-methoxy-2-(2-methoxyethyl)-1 -indanone, was extensively invest

^IlfWestVirginiaUniversityTHE RESEARCH REPOSITORY @ wvuGraduate Theses, Dissertations, and Problem Reports2013Development of a Synthetic Pathway Towar

Development of an Evidence-Based Nursing Orientation Program fortween the 1-indanone and the cthyny] derivatives produced the benzannulatcd enediynyl propargylic alcohol. Chlorinated PAI Is as potential precursors

leading to the bowl-shpaed hydrocarbon have been successfully synthesized.DEDICATED TOMy ParentsJin-que Fang and Si-yan SunijiACKNOWLEDGEMENTSI would Development of an Evidence-Based Nursing Orientation Program for

like to express my sincere gratitude to my advisor Dr. Kung Wang for his guidance, encouragement, and continuous support. He has inspired and advised

Development of an Evidence-Based Nursing Orientation Program for

me to grow intellectually and technically in organic research areas. He has never ceased to teach and inspire me to be a better scientist and person.

^IlfWestVirginiaUniversityTHE RESEARCH REPOSITORY @ wvuGraduate Theses, Dissertations, and Problem Reports2013Development of a Synthetic Pathway Towar

Development of an Evidence-Based Nursing Orientation Program forvice, patience, and kindness.My special thanks go to Dr. Novruz Akhmedov for his help and support in NMR and Mass Spectroscopy. I acknowledge the fina

ncial support of the Department of Chemistry at West Virginia University.I would also like to thank my group members, past and present, for their supp Development of an Evidence-Based Nursing Orientation Program for

ort and friendship. Particularly I am indebted to Mr. Chi-Yuan Tseng for his help and valuable discussions in the lab.1 thank my parents and my wife,

Development of an Evidence-Based Nursing Orientation Program for

Hui-Ju Hung, and my daughter Christine for their everlasting love and encouragement. Without their unconditional support. I could not come this far.

^IlfWestVirginiaUniversityTHE RESEARCH REPOSITORY @ wvuGraduate Theses, Dissertations, and Problem Reports2013Development of a Synthetic Pathway Towar

^IlfWestVirginiaUniversityTHE RESEARCH REPOSITORY @ wvuGraduate Theses, Dissertations, and Problem Reports2013Development of a Synthetic Pathway Towar

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