Maricopa Association of Governments
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Maricopa Association of Governments
LymphTF DatabaseA Database of Transcription factor activity IN Lymphocyte DevelopmentPall ChildressSubmitted to the faculty of the Bioinformatics Grad Maricopa Association of Governmentsduate Program in partial fulfillment of the requirements for the degree Master of Science in the School of Informatics, Indiana University September 2005iAccepted by the Bioinformatics Program Graduate Faculty, Indiana University, in partial fulfillment of the requirements for the degree of Master o Maricopa Association of Governmentsf Science in Bioinformatics.Master’s CommitteeNarayanan B. Perumal, PhDMalika Mahoui, PhDMark H. Kaplan. PhDiiDedicationIhis thesis and indeed my entiMaricopa Association of Governments
re graduate education arc dedicated to Mason and Joshua Childness. 1 hey arc wonderful sons and a continuing source for inspiration and motivation.iiiLymphTF DatabaseA Database of Transcription factor activity IN Lymphocyte DevelopmentPall ChildressSubmitted to the faculty of the Bioinformatics Grad Maricopa Association of Governmentshis possible. Thank You!Mr. Charles Moad provided me with some very helpful hints in the design of the database and I would like to thank him very much.Bhanu Potugari helped with PHP coding advice and hints for website design without which this project would have been very difficult.Finally, I would Maricopa Association of Governments like to thank Dr. Mark Kaplan and Dr. Malika Mahoui for serving on my advisory' committee.ivAbstractstudy of the transcriptional regulation of lymphoMaricopa Association of Governments
cyte development has advanced greatly in the past 15 years. Owing to improved techniques and intense interest in the topic, a great many interactions LymphTF DatabaseA Database of Transcription factor activity IN Lymphocyte DevelopmentPall ChildressSubmitted to the faculty of the Bioinformatics Grad Maricopa Association of Governmentsthey start with a common progenitor cell, and progressively restrict potential to give many different types of terminally differentiated cells. As B and T cells develop they both follow a roughly similar path that involves early stepwise progression to later stages where multiple developmental optio Maricopa Association of Governmentsns are available. To progress in the developmental regime they share requirements for proper anatomical location and successful rearrangements of theMaricopa Association of Governments
germ line DNA to give the plethora of antibodies and T cell receptors seen in the immune system. Because the amount of information is quickly becomingLymphTF DatabaseA Database of Transcription factor activity IN Lymphocyte DevelopmentPall ChildressSubmitted to the faculty of the Bioinformatics Grad Maricopa Association of Governmentsrocess and what any one individual can recall. To help fill this gap. we have created the LymphTF Database. This database holds interactions between individual transcription factors and their specific targets at a given developmental time. It is our hope that storing the interactions in developmenta Maricopa Association of Governmentsl time will allow for elucidation of regulatory networks which guide the process. Work for this project also included construction of a custom data enMaricopa Association of Governments
try web page that automates many tasks associated with populating the database tables. These tables have also been related in multiple ways to allow fLymphTF DatabaseA Database of Transcription factor activity IN Lymphocyte DevelopmentPall ChildressSubmitted to the faculty of the Bioinformatics Grad Maricopa Association of Governmentsable. The LymphTF DB IS a relational MySQL database which can be accessed freely on the web at http://www.iupui.edu/~tfinterx/.VTable of ContentsIntroduction-_________________________________________________1-13Lymphocyte development 1-10B cell development 2-5T cell development______________________ Maricopa Association of Governments________5-10Lymphocyte stages 10-131 mportance___________________________________________________14-22Developmental model system 14-16Clinical importaMaricopa Association of Governments
nce 16-17Genetic control model system____________________________18-20LymphTF DatabaseA Database of Transcription factor activity IN Lymphocyte DevelopmentPall ChildressSubmitted to the faculty of the Bioinformatics GradLymphTF DatabaseA Database of Transcription factor activity IN Lymphocyte DevelopmentPall ChildressSubmitted to the faculty of the Bioinformatics GradGọi ngay
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