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natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

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Nội dung chi tiết: natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

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natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development in Clinical DevelopmentCrossMarkSatheesh Kumar Palanisamy • N. M. Rajcndran • Angela MarinoReceived: 19 November 2016/Accepted: 14 December 20)6© The

Authorfs) 2017. This article is published with open access al Springcrtink.comAbstract This present study reviewed the chemical diversity of marine a natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

scidians and their pharmacological applications, challenges and recent developments in marine drug discovery reported during 1994 2014, highlighting t

natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

he structural activity of compounds produced by these specimens. Till dale only 5% of living ascidian species were studied from <3(XX) species, this s

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natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical developments. Close to 580 compound structures are here discussed tn terms of their occurrence, structural type and reported biological activity. Anti-cancer dru

gs are the main area of interest in the screening of MNPs from ascidians (64%). followed by anti-malarial (6%) and remaining others. FDA approved asci natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

dian compounds mechanism of action along with other compounds status of clinical trials (phase I to phase 3) are discussed here in. This review highli

natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

ghts recent developments in the area of natural products chemistry and biotechnological approaches are emphasized.Keywords Cancer • Cytotoxicity ■ Div

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natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical developmentollaborative effort between marine biologist, chemist and pharmacologist. which involves the discovery of new natural products to enter preclinical st

udies and clinical tests. Since the 1990s, several MNPs and their applications towards marine biotechnological and therapeutical potential were report natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

ed. Large numbers of bioactive compounds were dragged ups. K. Palanisamy (F3) • A. MarinoDepartment of Chemical. Biological. Pharmaceutical and Enviro

natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

nmental Science. University of Messina. 98166 Messina.Italye-mail: spalanisamy@unime.ilN. M. RajendranKey Laboratory of Engineering Plastics and Beiji

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natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical developmentpecially sponges, ascidians, bryozoans and molluscs in which some of them are approved by FDA and currently utilized in clinical trials [I J.Ascidians

or sea squills (Phylum: Chordata. Class: Ascidiacea) are also known as tunicates due to their external covering, found tied to rocks and high-current natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

fields. There are approximately 3000 living species of ascidians were reported |2|. The production of chemical compounds is principally important for

natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

soli bodied ascidian species, which use secondary metabolites to deter predatory fishes, to compete for space, to control settlement and growth of mi

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natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical developmention of MNPs and provide rich sources of bioactive secondary metabolite with promising potential biomedical applications [3-5]. So far a few novel comp

ounds have been purified and characterized with a view of developing marine drug discovery. However, the most well knownPublished online: 17 January 2 natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

017*£J SpringerÔ. IS. raiamsamy Ct at.didemnins has been isolated from whole body homogenates of Caribbean ascidians belonging to the genus of Tridide

natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

-Ilium sp. [6], More than 80% of new ascidians compounds contain nitrogen, and nearly 70% of nitrogenous metabolites arc alkaloids |7-9|. These compou

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natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical developmentclin kinases [10], On the Ollier hand, non-nitrogenous metabolites are fewer available in ascidians and also less significant. Hence. identification o

f the bio-genetic origin of ascidian natural products is often challenging 111|. The first bioactivc metabolite geranyl hydroquinone was isolated from natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

the ascidian Aplidium sp. [12]: only 230 metabolites were isolated from ascidians during 1974 1992 [3],At that time, a wide-ranging attention has foc

natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

used on ascidians because of tbeir biologically active metabolites and the chemical diversity of ascidians has become one of the most significant sour

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natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development3|. Nonetheless, significant research in the area of marine pharmacology is a very recent origin, anti also few products (or their analogues) have alr

eady reached the market as therapeutic drugs. Indeed, ascidian-derived natural products have yielded promising drug leads, among which ecteinascidin 7 natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

43 (Yondelis*) and dchydrodidemnin B (Aplidin*) are in clinical usage for the treatment of specific cancers [14, 15].The research attempt on MNPs has

natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

not targeted all marine invertebrates equally. Ascidians are one of the most intensely studied organisms during the 21st century so that 572 secondary

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natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical developmentand polycitoridae (11 12%) exhibiting the highest numberof promising MNPs (Fig. I). Tile distribution of chemistry class of ascidian MNPs are given in

(Fig. 2). Close to 580 compound structures are here discussed in terms of their occurrence, structural type and reported biological activity. Anti-ca natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

ncer drags arc the main area of interest in the screening of M.NPs from ascidians (64%), followed by anti-malarial (6%) and remaining others (Fig. 3).

natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

The National Cancer Institute-United stales estimate that approximately 1%' of MNPs showing anti tumor cytotoxicity properties as against only 0.01%

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natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical developmentlop novel cures.Tills review focuses on the chemical diversity of marine ascidians. The recent research on MNPs has been surveyed at relatively freque

nt intervals |4, 5, 9, 13|. Davidson |3| was published the first review on secondary metabolites derived ascidians from 1988 to 1993. Additionally, in natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

contrast to the review of ascidian metabolites, the present study provides complete list of the compounds with biological activities: the primary foc

natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

us of this article is addressed to structures and properties of promising ascidian metabolites and their biological activities. In this latter regard,

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natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical developmentcancer compounds, described in marine ascidians during 1994-2014 were reported here in. In this study, we did not aim to review proceedings of confere

nce, scientific reports and patent literature. Wherever possible, we made attempt to focus on their potential biogenesis, chemical structure-activity natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

relationships. Nevertheless, the present study has been mainly focused on their recent developments in the prcclinical studies, biotechnology advances

natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

and future directions of ascidian secondary metabolites. Meanwhile, the possible cytotoxicity and growth inhibition of MNPs is an identifying and sho

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natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical developmentidian on I991-2OMDistribution of Cbeuintry ela>xs of MNP*Alkyl >uic>l>xFig. 2 Distribution of chemistry class of MNPs with high biomedical potential a

pplication studied from 1991 to 2011£2 Springer natural products diversity of marine ascidians tunicates ascidiacea and successful drugs in clinical development

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