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Solvent free beta carotene nanoparticles for food fortification

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Nội dung chi tiết: Solvent free beta carotene nanoparticles for food fortification

Solvent free beta carotene nanoparticles for food fortification

RUTGERS. THE STATE UNIVERSITY OF NEW JERSEYPHONG TIEN HUYNHSOLVENT-FREE BETA-CAROTENENANOPARTICLES FOR FOOD FORTIFICATIONNew Brunswick. New Jersey4118

Solvent free beta carotene nanoparticles for food fortification 83SOLVENT-FREE BETA-CAROTENE NANOP ARTICLES FOR FOODFORTIFICATIONByPHONG TIEN HUYNHA dissertation submitted to theGraduate School - New BrunswickRutge

rs. The State University of New Jersey in partial fulfillment of the requirements for the degree ofDoctor of PhilosophyGraduate program it) Food Scien Solvent free beta carotene nanoparticles for food fortification

ce Written under the direction ofProfessor PAUL TAKIỈISTOVNew Brunswick, New Jersey41183ABSTRACT OF THE DISSERTATIONSOLVENT-FREE BETA-CAROTENE NANOPAR

Solvent free beta carotene nanoparticles for food fortification

TICLES FOR FOOD FORTIFICATIONBy PHONG TIEN HUYNHDissertation director:Professor PAUL TAKHISTOVMost nutraceutical compounds are poorly-water soluble. T

RUTGERS. THE STATE UNIVERSITY OF NEW JERSEYPHONG TIEN HUYNHSOLVENT-FREE BETA-CAROTENENANOPARTICLES FOR FOOD FORTIFICATIONNew Brunswick. New Jersey4118

Solvent free beta carotene nanoparticles for food fortification g way to improve the solubility of hydrophobic compounds. Nanoparticles increase the total surface area of the poorly-water soluble nutraceuticals mak

ing them more bioavailable.Some traditional methods for decreasing panicle size include pearl or jet milling, where paitides are broken down through g Solvent free beta carotene nanoparticles for food fortification

rinding or collisions under high pressure These mechanical processes not only require high energy input but also raise a concern of milling media resi

Solvent free beta carotene nanoparticles for food fortification

dues. The high pressure homogenizer approach applies implosion forces and collision of panicles to generate nanosuspensions. This method requires micr

RUTGERS. THE STATE UNIVERSITY OF NEW JERSEYPHONG TIEN HUYNHSOLVENT-FREE BETA-CAROTENENANOPARTICLES FOR FOOD FORTIFICATIONNew Brunswick. New Jersey4118

Solvent free beta carotene nanoparticles for food fortification actice is a novel approach in which a poorly-water soluble compound is transferred into nanoemulsion droplets of a partially water-soluble organic sol

vent. The compound then crystallizes because the solvent diffuses out of the emulsion droplets. The key point of proposed emulsion-diffusion technolog Solvent free beta carotene nanoparticles for food fortification

y IS that the phase transition occius within an isolated nanoemulsion droplet.The mam prupose of this study IS to develop a “gr een” and scalable meth

Solvent free beta carotene nanoparticles for food fortification

od for prepar ing nanosuspensions of highly hydrophobic compounds. We use FDA GRAS ingredients to create nanoparticles of poorly-water soluble nutrace

RUTGERS. THE STATE UNIVERSITY OF NEW JERSEYPHONG TIEN HUYNHSOLVENT-FREE BETA-CAROTENENANOPARTICLES FOR FOOD FORTIFICATIONNew Brunswick. New Jersey4118

Solvent free beta carotene nanoparticles for food fortification sed phase of nanoemulsions. The influence of surfactant, water concentration, and homogenization time on panicle size and stability is investigated. T

he impact of surfactant on diffusion flux of triacetin is studied. Kolmogorov theory is applied to reveal the breakup mechanism of emulsion droplets u Solvent free beta carotene nanoparticles for food fortification

nder shear and predict their size A mathematical model is built to discover the size of emulsion droplet during the formation of nanosuspensions. It i

Solvent free beta carotene nanoparticles for food fortification

s hoped that the this work will greatly advance the manufacture of nanoparticles of poorly-water soluble nutraceuticalsiiiACKNOWI F.DGF.MFNTS1 would l

RUTGERS. THE STATE UNIVERSITY OF NEW JERSEYPHONG TIEN HUYNHSOLVENT-FREE BETA-CAROTENENANOPARTICLES FOR FOOD FORTIFICATIONNew Brunswick. New Jersey4118

Solvent free beta carotene nanoparticles for food fortification cals, simulations and colloidal science. in addition, 1 would like to thank Ilim for always supporting my somewhat non-conventional ideas for side pro

jects. Ĩ would also like to thank members of professor lakhistov’s group including: Marlcna Brown, Abliishck Saha}. Maha Ashchab for their collaborati Solvent free beta carotene nanoparticles for food fortification

ons knowledge, and support throughout rhe years. Tn addition. Ĩ would like to thank Dr Changhoon Chai for advices and helps ar beginning. Ĩ would like

Solvent free beta carotene nanoparticles for food fortification

to tliank Dr. Khusid, Dr Yam. and Dr Karwe for then great suggestions and discussions. 1 would like acknowledge US government and Vietnamese governme

RUTGERS. THE STATE UNIVERSITY OF NEW JERSEYPHONG TIEN HUYNHSOLVENT-FREE BETA-CAROTENENANOPARTICLES FOR FOOD FORTIFICATIONNew Brunswick. New Jersey4118

RUTGERS. THE STATE UNIVERSITY OF NEW JERSEYPHONG TIEN HUYNHSOLVENT-FREE BETA-CAROTENENANOPARTICLES FOR FOOD FORTIFICATIONNew Brunswick. New Jersey4118

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