libretto_acesap_zugna_19-20_maggio_finale
➤ Gửi thông báo lỗi ⚠️ Báo cáo tài liệu vi phạmNội dung chi tiết: libretto_acesap_zugna_19-20_maggio_finale
libretto_acesap_zugna_19-20_maggio_finale
1Mapping multidimensional pain experience onto electrophysiological responsesto noxious laser heat stimuli.Andrej Stancak. Stephanie Cook. Hazel Wrigh libretto_acesap_zugna_19-20_maggio_finaleht, Nicholas FallonDepartment of Psychological Sciences. University of Liverpool. Liverpool. L69 7ZAUnited KingdomCorresponding author:Andrej Stancak, PhD.Department of Psychological SciencesUniversity of LiverpoolLiverpool. L69 7ZAUnited KingdomE-mail: a.stancak@liYerpQQl.ac.ukPhone: +44 151 794695 libretto_acesap_zugna_19-20_maggio_finale1Acknowledgements. We are grateful to Dr. Xiaoyun Li for her assistance during data recordings. The authors declare no competing financial interests.2libretto_acesap_zugna_19-20_maggio_finale
AbstractThe origin of the conscious experience of pain in the brain is a continuing enigma in neuroscience. To shed light on the brain representation 1Mapping multidimensional pain experience onto electrophysiological responsesto noxious laser heat stimuli.Andrej Stancak. Stephanie Cook. Hazel Wrigh libretto_acesap_zugna_19-20_maggio_finalenalysis of electrophysiological brain responses.Participants were asked to fully focus on any painful or non-painful sensations occurring in their left hand during an interval surrounding the onset of noxious laser heat stimuli, and to rate their sensations using a set of visual analogue scales. Sta libretto_acesap_zugna_19-20_maggio_finaletistical parametric mapping was used to compute a multivariate regression analysis of subjective responses and single-trial laser evoked potentials (Llibretto_acesap_zugna_19-20_maggio_finale
EPs) at subject and group levels. Standardized Low Resolution Electromagnetic Tomography (sLORETA) method was used to reconstruct sources of LEPs.Fact1Mapping multidimensional pain experience onto electrophysiological responsesto noxious laser heat stimuli.Andrej Stancak. Stephanie Cook. Hazel Wrigh libretto_acesap_zugna_19-20_maggio_finaletive potential at the fronto-temporal region during the 208-260 ms interval, and secondly as a strong negative potential in the right lateral frontal and prefrontal scalp regions during the 1292-1340 ms interval. Three other factors, labelled "anticipated pain", “stimulus onset time", and “body sens libretto_acesap_zugna_19-20_maggio_finaleations”, represented non-specific aspects of the pain experience, and explained portions of LEPs in the latency range from 200 ms to 700 ms.The subjeclibretto_acesap_zugna_19-20_maggio_finale
tive space of pain during noxious laser stimulation is represented by one large factor featuring pain intensity, and by other factors accounting for n1Mapping multidimensional pain experience onto electrophysiological responsesto noxious laser heat stimuli.Andrej Stancak. Stephanie Cook. Hazel Wrigh libretto_acesap_zugna_19-20_maggio_finalekhothuvien.cori!31. IntroductionIn contrast to visual, auditor}' or tactile systems, primary conical regions underlying the conscious perception of pain remain elusive. The posterior insula and adjacent parietal operculum have been shown to be the only brain regions capable of producing a sensation libretto_acesap_zugna_19-20_maggio_finaleof pain during electrical stimulation, suggesting their role in the formation of the conscious experience of pain (Mazzola et al., 2012; Ostrowsky etlibretto_acesap_zugna_19-20_maggio_finale
al., 2002). Patients with lesions in posterior insula (Biemond, 1956; Greenspan et al., 1999) or parietal operculum (Horiuchi et al., 1996) may show h1Mapping multidimensional pain experience onto electrophysiological responsesto noxious laser heat stimuli.Andrej Stancak. Stephanie Cook. Hazel Wrigh libretto_acesap_zugna_19-20_maggio_finaleg the pain experience (Garcia-Larrea, 2012). Subregions of insula differentiated painful from non-painful sensations in fMRI (Pomares et al., 2013). However, as pain is a multidimensional experience involving specific sensory qualities such as intensity, negative affect, awareness of stimulus occurr libretto_acesap_zugna_19-20_maggio_finaleence, spatial and temporal localisation, perceived control over pain (Salomons et al., 2004), prediction error (Roy et al., 2014), and novelty or salilibretto_acesap_zugna_19-20_maggio_finale
ency (Downar et al., 2003; lannetti et al., 2008; Mouraux and lannetti, 2009), it is likely that brain regions other than the posterior insula partici1Mapping multidimensional pain experience onto electrophysiological responsesto noxious laser heat stimuli.Andrej Stancak. Stephanie Cook. Hazel Wrigh libretto_acesap_zugna_19-20_maggio_finale experience has long been acknowledged (Melzack and Casey, 1968), brain representations of distinct aspects of pain are poorly understood. Pain intensity, the most conspicuous aspect of the pain experience, appears to be encoded in a number of regions including thalamus, insula, primary and secondar libretto_acesap_zugna_19-20_maggio_finaley somatosensory cortex, anterior cingulate cortex and other brain regions (Atlas et al., 2014; Coghill et al., 1999; Wager et al., 2013). A novel4multlibretto_acesap_zugna_19-20_maggio_finale
ivariate pattern analysis showed that near-threshold painful laser stimuli are differentiated from non-painful stimuli in primary' and secondary' soma1Mapping multidimensional pain experience onto electrophysiological responsesto noxious laser heat stimuli.Andrej Stancak. Stephanie Cook. Hazel Wrigh libretto_acesap_zugna_19-20_maggio_finaleonses of the brain during laser induced pain, known as laser evoked potentials (LEPs), have been shown to bear a relationship with pain intensity (Frot et al., 2007; Hu et al., 2014; lannetti et al., 2005; Le Pera et al., 2007; Stancak et al.. 2012; Wager et al., 2006). Although fractionation of pai libretto_acesap_zugna_19-20_maggio_finalen intensity and unpleasantness has been reported under specific conditions such as hypnosis (Rainville et al., 1999) or dopamine precursor depletion (libretto_acesap_zugna_19-20_maggio_finale
Tiemann et al., 2014), these two and other pain dimensions are strongly inter-correlated (Holroyd et al., 1992; Turk et al., 1985). The degree and qua1Mapping multidimensional pain experience onto electrophysiological responsesto noxious laser heat stimuli.Andrej Stancak. Stephanie Cook. Hazel Wrigh libretto_acesap_zugna_19-20_maggio_finalein and brain activity difficult.To shed light on brain representations of pain induced by noxious laser stimuli, statistical parametric mapping of associations between subjective scales and single-trial LEPs was carried out. Laser intensity was maintained at a constant level over repeated stimuli, s libretto_acesap_zugna_19-20_maggio_finaleimilar to previous electrophysiological (Schulz et al.. 2011; Schulz et al., 2012) and fMRI studies (Brodersen et al., 2012; Ploner et al., 2010; Wieclibretto_acesap_zugna_19-20_maggio_finale
h et al., 2010). Although local differences in the density of nocisensors and small variations in the energy of laser pulses contributed to inter-tria1Mapping multidimensional pain experience onto electrophysiological responsesto noxious laser heat stimuli.Andrej Stancak. Stephanie Cook. Hazel Wrigh libretto_acesap_zugna_19-20_maggio_finaleuting to the variability of the pain experience.2. Methods and Materials2.1. Subjects and procedurehttps://khothuvien.cori!5Sixteen healthy participants (7 males, 9 females), undergraduate and postgraduate students of psychology and medicine, aged 24.7 ± 4.1 years (mean ± SD) took part in the study libretto_acesap_zugna_19-20_maggio_finaleafter giving their written informed consent according to the Declaration of Helsinki. The procedures were approved by the University of Liverpool reselibretto_acesap_zugna_19-20_maggio_finale
arch ethics committee. Participants received £15 to compensate for their time and travel expenses.Subjects were informed about the purpose of the expe1Mapping multidimensional pain experience onto electrophysiological responsesto noxious laser heat stimuli.Andrej Stancak. Stephanie Cook. Hazel Wrigh libretto_acesap_zugna_19-20_maggio_finaleevery single sensation preceding or following a laser stimulus. Subjects were told that, regardless of the identical intensity of the laser stimuli, their sensations were likely to vary across 60 trials.Laser stimuli were applied using an Nd-YAP laser stimulator (Stiml324, El.En., Italy). The pulse libretto_acesap_zugna_19-20_maggio_finaleduration was 4 ms, and the spot size was 5 mm. The intensity of the laser stimulus was adjusted for each subject individually prior to the first blocklibretto_acesap_zugna_19-20_maggio_finale
by incrementing the stimulus intensity from 1.25 J in steps of 0.25 J. The intensity producing a moderate pain sensation rated 5 or 6 on a 10-point r1Mapping multidimensional pain experience onto electrophysiological responsesto noxious laser heat stimuli.Andrej Stancak. Stephanie Cook. Hazel Wrigh1Mapping multidimensional pain experience onto electrophysiological responsesto noxious laser heat stimuli.Andrej Stancak. Stephanie Cook. Hazel WrighGọi ngay
Chat zalo
Facebook